Expression of aryl hydrocarbon receptor (AHR) and aryl hydrocarbon receptor nuclear translocator (ARNT) mRNA expression in human spermatozoa

Medical Science Monitor

Volumn 10, Issue 5, 2004, Pages

  Khorram, Omid ^a,b   Garthwaite, Mark ^a   Jones, Jeffrey ^a   Golos, Thaddeus ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

ARNT; Dioxin receptor; Human sperm; Male infertility

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; BIPHENYL DERIVATIVE; DIOXIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HYPOXIA INDUCIBLE FACTOR 1BETA; MESSENGER RNA; POLYCYCLIC AROMATIC HYDROCARBON; POLYHALO DERIVATIVE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CELL STRUCTURE; CLINICAL ARTICLE; COMPUTER ANALYSIS; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; MALE; MALE INFERTILITY; OLIGOSPERMIA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEMEN ANALYSIS; SPERMATOZOON; SPERMATOZOON DENSITY; SPERMATOZOON MOTILITY;

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CASE-CONTROL STUDIES; CELL MOVEMENT; COHORT STUDIES; DIOXINS; DNA PRIMERS; HUMANS; HYDROCARBONS; INFERTILITY, MALE; MALE; PROTEIN BINDING; RECEPTORS, ARYL HYDROCARBON; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEMEN; SPECTROPHOTOMETRY; SPERMATOZOA; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 2942752296     PISSN: 12341010     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Gasiwicz TA: Dioxin and the Ah Receptor: Probes to uncover processes in neuroendocrine development. Neurotoxicol, 1997; 18: 393-414
2. Giwercman A, Bonde JP: Declining male fertility and environmental factors. Endocrinol and Metab Clin of North America, 1998; 27: 807-30
3. Moline JM, Golden AL, Bar-Chama N et al: Exposure to hazardous substances and male reproductive health: A research framework. Environ Health Perspect, 2000; 108: 803-13
4. Theobold HM, Peterson RE: In utero and lactational exposure to 2, 3, 7, 8 Tetrachlorodibenzo-p-dioxin: Effects on development of the male and female reproductive system of mouse. Toxicol and Appl Pharmacol, 1997; 145: 124-35
5. Sommer RJ, Ippolito DL, Petersen RE: In utero and lactational exposure of the male Holtzman rat to 2, 3, 7, 8-tetra chloro-p-dioxin: decreased epididymal and ejaculated sperm numbers without alteration in sperm transit rate. Toxicol Appl Pharmacol, 1996; 140: 146-53
6. Wilker C, Johnson L, Safe S: Effects of developmental exposure to indole-3-carbinol or 2, 3, 7, 8-tetrachloro dioxin on reproductive potential of male rat offspring. Toxicol Appl Pharmacol, 1996; 141: 68-75
7. Johnson L, Dickerson R, Safe SH et al: Reduced Leydig cell volume and function in adult rats exposed to 2, 3, 7, 8 Tetrachlorodibenzo-p-dioxin without a significant effect on spermatogenesis. Toxicol, 1992; 76: 103-18
8. Guo YL, Hsu PC, Hsu CC, Lambert GH: Semen quality after prenatal exposure to polychlorinated biphenyls and dibenzofurans. Lancet, 2000; 356: 1240-41
9. El-Sabeawy F, Wang S, Overstreet J et al: Treatment of rats during pubertal development with 2, 3, 7, 8-tetrachorodibnzo-p-dioxin alters both signaling kinase activities and epidermal growth factor receptor binding in the testis and the motility and acrosomal reacdon ofsperm. Toxicol Appl Pharmacol, 1999; 150: 427-42
10. Celis RD, Feria-Velasco A, Gozalez-Unzaga M et al: Semen quality of workers occupationally exposed to hydrocarbons. Fertil and Steril, 2000; 73: 221-28
11. Schecter A, McGee H, Stanley JS et al: Dioxins and dioxin-like chemicals in blood and semen of American Vietnam veterans from the state of Michigan. Am J of Indust Med, 1996; 30: 647-54
12. Masten SA, Shieverick KT: Characterization of the aryl hydrocarbon receptor complex in human B lymphocytes: Evidence for a distinct nuclear DNA-binding form. Arch of Biochem Biophys, 1996; 336: 297-308
13. Lawrence BP, Leid M, Kerkuliet NI: Distribution and behavior of the Ah receptor in murine T lymphocytes. Toxicol and Appl Pharmacol, 1996; 138: 275-84
14. Nebert DW, Roe AL, Dieter MZ et al: Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis. Biochem Pharmacol, 2000; 59: 65-85
15. Maltepe E, Schmidt JV, Baunoch D et al: Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature, 1997; 386: 403-7