Smoke induced changes in epithelial cell gene expression: Development of an in vitro model for COPD

Altex

Volumn 21, Issue 1, 2004, Pages 3-7

  Puljic, Ruzica ^a   Pahl, Andreas ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

3R; Chemokines; Cigarette smoke; COPD; Epithelial cells; Inflammation

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTIOXIDANT; CD8 ANTIGEN; CHEMOKINE; CIGARETTE SMOKE; DEXAMETHASONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; PYRROLIDINE DITHIOCARBAMATE; RANTES; TUMOR NECROSIS FACTOR ALPHA;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CHRONIC BRONCHITIS; CHRONIC INFLAMMATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CIGARETTE SMOKING; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG SCREENING; DRUG TARGETING; EMPHYSEMA; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNE RESPONSE; IN VITRO STUDY; LUNG ALVEOLUS EPITHELIUM; PATHOGENESIS; ADENOCARCINOMA; BIOLOGICAL MODEL; CYTOLOGY; DRUG EFFECT; EPITHELIUM CELL; GENETICS; IMMUNOLOGY; LUNG; LUNG TUMOR; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RESPIRATORY TRACT MUCOSA; SMOKE; TUMOR CELL LINE;

ADENOCARCINOMA; CELL LINE, TUMOR; CHEMOKINES; DEXAMETHASONE; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; HUMANS; LUNG; LUNG NEOPLASMS; MODELS, BIOLOGICAL; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATORY MUCOSA; SMOKE;

EID: 2942752051     PISSN: 09467785     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Calverley, P. M. and Walker, P. (2003). Chronic obstructive pulmonary disease. Lancet 362, 1053-61.
2. Chandel, N. S., Trzyna, W. C., McClintock, D. S. and Schumacker, P. T. (2000). Role of oxidants in NF-kappaB activation and TNF-alpha gene transcription induced by hypoxia and endotoxin. J. Immunol. 165, 1013-1021.
3. Hill, A., Gompertz, S. and Stockley, R. (2000). Factors influencing airway inflammation in chronic obstructive pulmonary disease. Thorax 55, 970-977.
4. Keatings, V. M., Jatakanon, A., Worsdell, Y. M. and Barnes, P. J. (1997). Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD. Am. J. Respir. Crit. Care Med. 155, 542-548.
5. Knight, D. (2001). Epithelium-fibroblast interactions in response to airway inflammation. Immunol. Cell Biol. 79, 160-164.
6. MacNee, W. (2001). Oxidative stress and lung inflammation in airways disease. Eur. J. Pharmacol. 429, 195-207.
7. Masubuchi, T., Koyama, S., Sato, E. et al. (1998). Smoke extract stimulates lung epithelial cells to release neutrophil and monocyte chemotactic activity. Am. J. Pathol. 153, 1903-1912.
8. Nowak, D., Ruta, U. and Piasecka, G. (1990). Nicotine increases human polymorphonuclear leukocytes chemotactic response - a possible additional mechanism of lung injury in cigarette smokers. Exp. Pathol. 39, 37-43.
9. Pechkovsky, D. V., Zissel, G., Ziegenhagen, M. W. et al. (2000). Effect of proinflammatory cytokines on interleukin-8 mRNA expression and protein production by isolated human alveolar epithelial cells type II in primary culture. Eur. Cytokine Netw. 11, 618-625.
10. Rahman, I. (2002). Oxidative stress and gene transcription in asthma and chronic obstructive pulmonary disease: anti-oxidant therapeutic targets. Curr. Drug Targets Inflamm. Allergy 1, 291-315.
11. Rusznak, C., Mills, P. R., Devalia, J. L. et al. (2000). Effect of cigarette smoke on the permeability and IL-1beta and sICAM-1 release from cultured human bronchial epithelial cells of never-smokers, smokers, and patients with chronic obstructive pulmonary disease. Am. J. Respir. Cell Mol. Biol. 23, 530-536.
12. Sabroe, I., Lloyd, C. M., Whyte, M. K. et al. (2002). Chemokines, innate and adaptive immunity, and respiratory disease. Eur. Respir. J. 19, 350-355.
13. Saetta, M., Baraldo, S., Corbino, L. et al. (1999). CD8+ve cells in the lungs of smokers with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 160, 711-717.
14. Sato, E., Koyama, S., Takamizawa, A. et al. (1999). Smoke extract stimulates lung fibroblasts to release neutrophil and monocyte chemotactic activities. Am. J. Physiol. 277, L1149-1157.
15. Siafakas, N. M. and Tzortzaki, E. G. (2002). Few smokers develop COPD. Why? Respir. Med. 96, 615-24.
16. Tetley, T. D. (2002). Macrophages and the pathogenesis of COPD. Chest 121, 156S-159S.