-
3
-
-
0018382647
-
A re-examination of purine and pyrimidine synthesis in the three main forms of Trypanosoma cruzi
-
Gutteridge W.E., Gaborak M. A re-examination of purine and pyrimidine synthesis in the three main forms of Trypanosoma cruzi. International Journal of Biochemistry. 10:1979;415-422
-
(1979)
International Journal of Biochemistry
, vol.10
, pp. 415-422
-
-
Gutteridge, W.E.1
Gaborak, M.2
-
5
-
-
0034521429
-
Efficient identification of inhibitors targeting the closed active site conformation of the HPRT from Trypanosoma cruzi
-
Freymann D.M., Wenck M.A., Engel J.C., Feng J., Focia P.J., Eakin A.E., Craig S.P. Efficient identification of inhibitors targeting the closed active site conformation of the HPRT from Trypanosoma cruzi. Chemistry and Biology. 7:2000;957-968
-
(2000)
Chemistry and Biology
, vol.7
, pp. 957-968
-
-
Freymann, D.M.1
Wenck, M.A.2
Engel, J.C.3
Feng, J.4
Focia, P.J.5
Eakin, A.E.6
Craig, S.P.7
-
6
-
-
0346493091
-
Interactions at the dimer interface influence the relative efficiencies for purine nucleotide synthesis and pyrophosphorolysis in a phosphoribosyltransferase
-
Canyuk B., Medrano F.J., Wenck M.A., Focia P.J., Eakin A.E., Craig S.P. Interactions at the dimer interface influence the relative efficiencies for purine nucleotide synthesis and pyrophosphorolysis in a phosphoribosyltransferase. Journal of Molecular Biology. 335:2004;905-921
-
(2004)
Journal of Molecular Biology
, vol.335
, pp. 905-921
-
-
Canyuk, B.1
Medrano, F.J.2
Wenck, M.A.3
Focia, P.J.4
Eakin, A.E.5
Craig, S.P.6
-
7
-
-
0026501290
-
Steady-state kinetics of the schistosomal hypoxanthine-guanine phosphoribosyltransferase
-
Yuan L., Craig S.P., McKerrow J.H., Wang C.C. Steady-state kinetics of the schistosomal hypoxanthine-guanine phosphoribosyltransferase. Biochemistry. 31:1992;806-810
-
(1992)
Biochemistry
, vol.31
, pp. 806-810
-
-
Yuan, L.1
Craig, S.P.2
McKerrow, J.H.3
Wang, C.C.4
-
8
-
-
0000477426
-
Steady-state kinetics of the hypoxanthine-guanine-xanthine phosphoribosyltransferase from Tritrichomonas foetus: The role of threonine-47
-
Munagala N.R., Chin M.S., Wang C.C. Steady-state kinetics of the hypoxanthine-guanine-xanthine phosphoribosyltransferase from Tritrichomonas foetus: the role of threonine-47. Biochemistry. 37:1998;4045-4051
-
(1998)
Biochemistry
, vol.37
, pp. 4045-4051
-
-
Munagala, N.R.1
Chin, M.S.2
Wang, C.C.3
-
9
-
-
0018177022
-
Human hypoxanthine-guanine phosphoribosyltransferase-steady state kinetics of the forward and reverse reactions
-
Giacomello A., Salerno C. Human hypoxanthine-guanine phosphoribosyltransferase-steady state kinetics of the forward and reverse reactions. The Journal of Biological Chemistry. 253:1978;6038-6044
-
(1978)
The Journal of Biological Chemistry
, vol.253
, pp. 6038-6044
-
-
Giacomello, A.1
Salerno, C.2
-
10
-
-
0018801499
-
Human hypoxanthine-guanine phosphoribosyltransferase IMP-GMP exchange: Stoichiometry and steady state kinetics of the reaction
-
Salerno C., Giacomello A. Human hypoxanthine-guanine phosphoribosyltransferase IMP-GMP exchange: stoichiometry and steady state kinetics of the reaction. Journal of Biological Chemistry. 254:1979;10232-10236
-
(1979)
Journal of Biological Chemistry
, vol.254
, pp. 10232-10236
-
-
Salerno, C.1
Giacomello, A.2
-
11
-
-
0030935658
-
Kinetic mechanism of human hypoxanthine-guanine phosphoribosyltransferase: Rapid phosphoribosyl transfer chemistry
-
Xu Y., Eads J., Sacchettini J.C., Grubmeyer C. Kinetic mechanism of human hypoxanthine-guanine phosphoribosyltransferase: rapid phosphoribosyl transfer chemistry. Biochemistry. 36:1997;3700-3712
-
(1997)
Biochemistry
, vol.36
, pp. 3700-3712
-
-
Xu, Y.1
Eads, J.2
Sacchettini, J.C.3
Grubmeyer, C.4
-
12
-
-
0030789250
-
Hypoxanthine phosphoribosyltransferase from Trypanosoma cruzi as a target for structure-based inhibitor design: Crystallization and inhibition studies with purine analogs
-
Eakin A.E., Guerra A., Focia P.J., Torres-Martinez J., Craig S.P. Hypoxanthine phosphoribosyltransferase from Trypanosoma cruzi as a target for structure-based inhibitor design: crystallization and inhibition studies with purine analogs. Antimicrobial Agents and Chemotherapy. 41:1997;1686-1692
-
(1997)
Antimicrobial Agents and Chemotherapy
, vol.41
, pp. 1686-1692
-
-
Eakin, A.E.1
Guerra, A.2
Focia, P.J.3
Torres-Martinez, J.4
Craig, S.P.5
-
13
-
-
0030976596
-
Computer program for the equations describing the steady state of enzyme reactions
-
Varon R., Garcia-Sevilla F., Garcia-Moreno M., Garcia-Canovas F., Peyro R., Duggleby R.G. Computer program for the equations describing the steady state of enzyme reactions. Cabios. 13:1997;159-617
-
(1997)
Cabios
, vol.13
, pp. 159-617
-
-
Varon, R.1
Garcia-Sevilla, F.2
Garcia-Moreno, M.3
Garcia-Canovas, F.4
Peyro, R.5
Duggleby, R.G.6
-
15
-
-
0032506093
-
Limited proteolysis of a trypanosomal hypoxanthine phosphoribosyltransferase yields crystals that diffract X-rays to near atomic resolution
-
Nieves-Alicea R., Focia P.J., Craig S.P., Eakin A.E. Limited proteolysis of a trypanosomal hypoxanthine phosphoribosyltransferase yields crystals that diffract X-rays to near atomic resolution. Biochimica et Biophysica Acta. 1388:1998;500-505
-
(1998)
Biochimica et Biophysica Acta
, vol.1388
, pp. 500-505
-
-
Nieves-Alicea, R.1
Focia, P.J.2
Craig, S.P.3
Eakin, A.E.4
-
16
-
-
0032497936
-
Approaching the transition state in the crystal structure of a phosphoribosyltransferase
-
Focia P.J., Craig S.P., Eakin A.E. Approaching the transition state in the crystal structure of a phosphoribosyltransferase. Biochemistry. 37:1998;17120-17127
-
(1998)
Biochemistry
, vol.37
, pp. 17120-17127
-
-
Focia, P.J.1
Craig, S.P.2
Eakin, A.E.3
-
17
-
-
0011980245
-
General approaches to the design of inhibitors
-
M. Sandler, & H.J. Smith. Oxford: Oxford Univ. Press
-
Frick L., Wolfenden R. General approaches to the design of inhibitors. Sandler M., Smith H.J. Design of Enzyme Inhibitors as Drugs. 1989;19-48 Oxford Univ. Press, Oxford
-
(1989)
Design of Enzyme Inhibitors As Drugs
, pp. 19-48
-
-
Frick, L.1
Wolfenden, R.2
-
18
-
-
0030901860
-
Purine salvage enzymes of parasites as targets for structure based inhibitor design
-
Craig S.P., Eakin A.E. Purine salvage enzymes of parasites as targets for structure based inhibitor design. Parasitology Today. 13:1997;238-241
-
(1997)
Parasitology Today
, vol.13
, pp. 238-241
-
-
Craig, S.P.1
Eakin, A.E.2
-
19
-
-
0037763040
-
Analysis of 6-(2,2-dichloroacetamido)chrysene interaction with the hypoxanthine phosphoribosyltransferase from Trypanosoma cruzi
-
Medrano F.J., Wenck M.A., Engel J.C., Craig S.P. Analysis of 6-(2, 2-dichloroacetamido)chrysene interaction with the hypoxanthine phosphoribosyltransferase from Trypanosoma cruzi. Journal of Medicinal Chemistry. 46:2003;2548-2550
-
(2003)
Journal of Medicinal Chemistry
, vol.46
, pp. 2548-2550
-
-
Medrano, F.J.1
Wenck, M.A.2
Engel, J.C.3
Craig, S.P.4
|