Changes in serum concentrations of methylmalonic acid and vitamin B12 in cobalt-supplemented ewes and their lambs on two cobalt-deficient properties

New Zealand Veterinary Journal

Volumn 52, Issue 3, 2004, Pages 117-128

  Gruner, T M ^a   Sedcole, J R ^a   Furlong, J M ^a   Grace, N D ^b   Williams, S D ^c   Sinclair, G ^c   Sykes, A R ^a  

^a LINCOLN UNIVERSITY   (New Zealand)

^b AGRESEARCH GRASSLANDS   (New Zealand)

^c Canterbury Vets Ltd ^*  (New Zealand)

Author keywords

Cobalt supplementation; Ewes; Lambs; Serum methylmalonic acid; Serum vitamin B12

Indexed keywords

COBALT; CYANOCOBALAMIN; METHYLMALONIC ACID; PERMACO; PROLAJECT;

ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; FEMALE; LACTATION; LAMB; LIVER; LIVEWEIGHT GAIN; METHYLMALONIC ACIDEMIA; MILK; NONHUMAN; PASTURE; RECORDING; SAMPLE; SAMPLING; SHEEP; STATISTICAL SIGNIFICANCE; SUCKLING; SUPPLEMENTATION; THIRD TRIMESTER PREGNANCY;

LAMB; OVIS; OVIS ARIES;

EID: 2942740833     PISSN: 00480169     EISSN: 11760710     Source Type: Journal    
DOI: 10.1080/00480169.2004.36416     Document Type: Article

References (33)

1. Andrews ED. Cobalt deficiency. New Zealand Journal of Agriculture 92, 239–44, 1956
2. Andrews ED. Cobalt Deficiency in Sheep and Cattle. New Zealand Department of Agriculture Bulletin 180, Wellington, New Zealand, 1972
3. Andrews ED, Stephenson BJ, Anderson JP, Faithful WC. The effect of length of pastures on cobalt-deficiency disease in lambs. New Zealand Journal of Agricultural Research 1, 125–39, 1958
4. Anonymous. Production Animal Chemistry. Diagnostic Report, Labnet Animal Health Laboratory, Invermay, New Zealand, 2002
5. Clark RG. Cobalt/vitamin B12 deficiency from lamb to adult ewe. Proceedings of the 28th Seminar of the Society of Sheep and Beef Cattle Veterinarians of the New Zealand Veterinary Association. Pp 105–22, 1998
6. Clark RG, Wright DF, Millar KR, Rowland JD. Reference curves to diagnose cobalt deficiency in sheep using liver and serum vitamin B12 levels. New Zealand Veterinary Journal 37, 1–11, 1989
7. Dick AT. Aspiration biopsy of the liver in sheep. Australian Veterinary Journal 20, 298–303, 1944
8. Grace ND. The effect of increasing the vitamin B12 status of Romney ewes on foetal liver vitamin B12, milk vitamin B12 and liver vitamin B12 concentrations in suckling lambs. New Zealand Veterinary Journal 47, 97–100, 1999
9. Green R, Newmark PA, Musso AM, Mollin DL. The use of chicken serum for measurement of serum vitamin B12 concentration by radioisotope dilution:Description of method and comparison with microbiological assay results. British Journal of Haematology 27, 507–26, 1974
10. Greenhouse SW, Geisser S. On methods in the analysis of profile data. Psychometrika 24, 95–112, 1959
11. Gruner TM. Studies of vitamin B12 metabolism. PhD thesis, Lincoln University, New Zealand, 2001
12. Gruner TM, Sedcole JR, Furlong JM, Sykes AR. A critical evaluation of serum methylmalonic acid and vitamin B12 for the assessment of cobalt deficiency of growing lambs in New Zealand. New Zealand Veterinary Journal 52, 137–44, 2004
13. Hannam RJ, Judson GJ, Reuter DJ, McLaren LD, McFarlane JD. Effect of vitamin B12 injections on the growth of young Merino sheep. Australian Journal of Agricultural Research 31, 347–55, 1980
14. Hart LI, Andrews ED. Effect of cobaltic oxide pellets on the vitamin B12 content of ewes’ milk. Nature 184, 1243, 1959
15. Judson GJ, Caple IW, Langlands JP, Peter DW, Wheeler JL, Pearson CJ, Robards GE. Mineral nutrition of grazing ruminants in southern Australia. In:Wheeler JL, Pearson CJ, Robards GE (eds). Temperate Pastures:Their Production, Use and Management. Pp 377–85. Commonwealth Scientific and Industrial Research Organisation, Melbourne, Australia, 1987
16. Judson GJ, Turnbull RK, Kemp BR. Cobalt and vitamin B12 supplementation of young sheep. Proceedings of the Australian Society of Animal Production 19, 378–80, 1992
17. Judson GJ, Woonton TR, McFarlane JD, Mitsioulis A. Evaluation of cobalt pellets for sheep. Australian Journal of Experimental Agriculture 35, 41–9, 1995
18. Kennedy DG, O’Harte FPM, Blanchflower JW, Price DA. Sequential changes in propionate metabolism during the development of cobalt/vitamin B12 deficiency in sheep. Biological Trace Element Research 28, 233–41, 1991
19. Kennedy DG, Kennedy S, Young PB. Effects of low concentrations of dietary cobalt on rumen succinate concentrations in sheep. International Journal for Vitamin Research 66, 86–92, 1996
20. Marston HR. The requirement of sheep for cobalt or for vitamin B12. British Journal of Nutrition 24, 615–33, 1970
21. McMurray CH, Rice DA, McLoughlin M, Blanchflower WJ. Cobalt deficiency and the potential of using methylmalonic acid as a diagnostic and prognostic indicator. Trace Elements in Man and Animals-TEMA 5. Proceedings of the Fifth International Symposium. Pp 603–8, 1985
22. McMurray CH, Blanchflower WJ, Rice DA, McLoughlin M. Sensitive and specific gas chromatographic method for the determination of methylmalonic acid in the plasma and urine of ruminants. Journal of Chromatography Biomedical Applications 378, 201–7, 1986
23. Millar KR, Lorentz PP. Urinary methylmalonic acid as an indicator of the vitamin B12 status of grazing sheep. New Zealand Veterinary Journal 27, 90–2, 1979
24. Millar KR, Penrose ME. A comparison of vitamin B12 levels in the livers and sera of sheep measured by microbiological and radioassay methods. New Zealand Veterinary Journal 28, 97–9, 1980
25. Millar KR, Albyt AT, Bond GC. Measurement of vitamin B12 in the livers and sera of sheep and cattle and an investigation of factors influencing serum vitamin B12 in sheep. New Zealand Veterinary Journal 32, 65–70, 1984
26. O’Halloran MW, Skerman KD. The effect of treating ewes during pregnancy with cobaltic-oxide pellets on the vitamin B12 concentration and the chemical composition of colostrum and milk on lamb growth. British Journal of Nutrition 15, 99–108, 1961
27. Peart JN, Edwards RA, Donaldson E. The yield and composition of the milk of Finnish landrace × blackface ewes. II. Ewes and lambs grazed on pasture. Journal of Agricultural Science, Cambridge 85, 315–24, 1975
28. Quirk MF, Norton BW. The relationship between the cobalt nutrition of ewes and the vitamin B12 status of ewes and their lambs. Australian Journal of Agricultural Research 38, 1071–82, 1987
29. Rice DA, McLoughlin M, Blanchflower WJ, Goodall EA, McMurray CH. Methylmalonic acid as an indicator of vitamin B12 deficiency in grazing sheep. Veterinary Record 121, 472–3, 1987
30. Rice DA, McLoughlin M, Blanchflower WJ, McMurray CH, Goodall EA. Sequential changes in plasma methylmalonic acid and vitamin B12 in sheep eating cobalt-deficient grass. Biological Trace Element Research 22, 153–64, 1989
31. Shallow M, Ellis NJS, Judson JG. Sex-related responses to vitamin B12 and trace element supplementation in prime lambs. Australian Veterinary Journal 66, 250–1, 1989
32. Ulvund MJ. Ovine white-liver disease (OWLD). Vitamin B12 and methylmalonic acid (MMA) estimations in blood. Acta Veterinaria Scandinavica 31, 267–75, 1990
33. Underwood EJ, Suttle NF. Cobalt. The Mineral Nutrition of Livestock. 3rd Edtn. Pp 251–82. CABI Publishing, Wallingford, UK, 1999