Protective effect of increasing doses of famotidine, omeprazole, lansoprazole, and melatonin against ethanol-induced gastric damage in rats

Indian Journal of Pharmacology

Volumn 36, Issue 3, 2004, Pages 171-174

  Sener, Goksel ^a   Paskaloglu, K ^a   Ayanoglu Dulger G ^a  

^a MARMARA UNIVERSITY   (Turkey)

Author keywords

Free radical scavengers; H2 receptor blocker; Proton pump inhibitors

Indexed keywords

ALCOHOL; ANTIULCER AGENT; FAMOTIDINE; GLUTATHIONE; LANSOPRAZOLE; MELATONIN; MYELOPEROXIDASE; OMEPRAZOLE; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; ENZYME ACTIVITY; FEMALE; LIPID PEROXIDATION; MALE; MUCOSA INFLAMMATION; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; RAT; STOMACH ACID SECRETION; STOMACH INJURY; STOMACH MUCOSA; STOMACH PH; STOMACH PROTECTION; TISSUE LEVEL;

EID: 2942729730     PISSN: 02537613     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Kvietys PR, Twohig B, Danzell J, Specian RD. Ethanol-induced injury to the rat gastric mucosa. Role of neutrophils and xanthine oxidase-derived radicals. Gastroenterology 1990;98:909-20.
2. Pihan G, Regillo C, Szabo S. Free radicals and lipid peroxidation in ethanol- or aspirin-induced gastric mucosal injury. Dig Dis Sci 1987;32:1395-401.
3. Szabo S, Nagy L, Plebani M. Glutathione, protein sulfhydryls and cysteine proteases in gastric mucosal injury and protection. Clin Chim Acta 1992;206:95-105.
4. Shaw S, Herbert V, Colman N, Jayatýlleke E. Efffect of ethanol-generated free radicals on gastric intrinsic factor and glutathione. Alcohol 1990;7:153-7.
5. 2-receptor antagonists. Effects on myeloperoxidase-catalysed reactions and hydroxyl radical generation in a ferrous-hydrogen peroxide system. Biochem Pharmacol 1993;45:2389-97.
6. Lapenna D, Gioia S, Ciofani G, Festi D, Cuccurullo F. Antioxidant properties of omeprazole. FEBS Lett 1996;382:189-92.
7. Reiter RJ, Tan DX, Manchester LC, Qi W. Biochemical reactivity of melatonin with reactive oxygen and nitrogen species: a review of the evidence. Cell Biochem Biophys 2001;34:237-56.
8. Melchiorri D, Sewerynek E, Reiter RJ, Ortiz GG, Poeggeler B, Nistico G. Suppressive effect of melatonin administration on ethanol-induced gastroduodenal injury in rats in vivo. Br J Pharmacol 1997;121:264-70.
9. Shay H, Sun DCY, Gruenstein R. A quantitative method for measuring spontaneous gastric secretion in the rat. Gastroenterology 1954;26:906-13.
10. Bozkurt A, Yüksel M, Haklar G, Kurtel H, Yegen BÇ, Alican I. Adenosine protects against indomethacin-induced gastric damage in rats. Dig Dis Sci 1998;43:1258-63.
11. Aykaç G, Uysal M, Yalçin AS, Koçak-Toker N, Sivas A, Öz H. The effect of chronic ethanol ingestion on hepatic lipid peroxide, glutathione, glutathione peroxidase and glutathione transferase in rats. Toxicology 1985;36:71-6.
12. Bradley PP, Priebat DA, Christerser RD, Rothstein G. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol 1982;78:206-9.
13. Satoh H, Inatomi N, Nagaya H, Inada I, Nohara A, Nakamura N, et al. Antisecretory and antiulcer activities of a novel proton pump inhibitor AG-1749 in dogs and rats. J Pharmacol Exp Ther 1989;248:806-15.
14. 2-receptor antagonists of plazma membrane alterations in ethanol-induced gastritis. Dig Dis Sci 1996;41:2156-65.
15. Sener-Muratoglu G, Paskaloglu K, Arbak S, Hürdag C, Ayanoglu-Dülger G. Protective effect of famotidine, omeprazole, and melatonin against acetylsalicylic acid-induced gastric damage in rats. Dig Dsi Sci 2001;46:318-30.
16. Szabo S, Trier JS, Brown A, Schnoor J. Early vascular injury and increased vascular permeability in gastric mucosal injury caused by ethanol in the rat. Gastroenterology 1985;88:228-36.
17. Bubenik GA, Ayles HL, Friendship RM, Browm GM, Ball RO. Relationship between melatonin levels in plasma and gastrointestinal tissues and the incidence and severity of gastric ulcers in pigs. J Pineal Res 1998;24: 62-6.
18. Loguercio C, Taranto D, Beneduce F, Del Vecchio Blanco C, De Vincentiis A, Nardi G, et al. Glutathione prevents ethanol-induced gastric mucosal damage and depletion of sulfhydryl compounds in humans. Gut 1993;34:161-5.