Vitamin A and iron supplementation is as efficient as hormonal therapy in constitutionally delayed children

Clinical Endocrinology

Volumn 60, Issue 6, 2004, Pages 682-687

  Zadik, Z ^a,b   Sinai, T ^a   Zung, A ^a   Reifen, R ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b KAPLAN MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE; IRON; OXANDROLONE; RETINOL; SOMATOMEDIN C; TESTOSTERONE;

ADOLESCENT; ARTICLE; BODY HEIGHT; BODY WEIGHT; CHILDHOOD DISEASE; CLINICAL OBSERVATION; CONTROLLED STUDY; DELAYED PUBERTY; DIET SUPPLEMENTATION; DIETARY INTAKE; DRUG EFFICACY; GROWTH; GROWTH ACCELERATION; GROWTH HORMONE BLOOD LEVEL; HAIR; HEALTH PROGRAM; HORMONAL THERAPY; HUMAN; IRON BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; NUTRITION; OUTCOMES RESEARCH; PATIENT REFERRAL; PRIORITY JOURNAL; PUBERTY; RANDOMIZATION; SHORT STATURE; TESTIS; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION;

ADOLESCENT; ANALYSIS OF VARIANCE; ANDROGENS; DELAYED-ACTION PREPARATIONS; DRUG THERAPY, COMBINATION; HORMONE REPLACEMENT THERAPY; HUMANS; IRON; LINEAR MODELS; MALE; OXANDROLONE; PUBERTY, DELAYED; TESTOSTERONE; VITAMIN A;

EID: 2942729569     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2004.02034.x     Document Type: Article

References (34)

1. Ahmed, F. Khan, M.R. & Jackson A.A. (2001) Concomitant supplemental vitamin A enhances the response to weekly supplemental iron and folic acid in anemic teenagers in urban Bangladesh. American Journal of Clinical Nutrition, 74, 108-115.
2. Allen, L.H. (1994) Nutritional influences on linear growth: a general review. European Journal of Clinical Nutrition, 48 (Suppl.), 75-89.
3. Anonymous. (1989) Recommended Dietary Allowances, 10th edn. National Academy Press, Washington DC.
4. Burn, B.J. & Jacob, R.A. (1988) Vitamin A analogs as tests for liver vitamin A status in the rat. American Journal of Clinical Nutrition, 47, 458-462.
5. Buyukgbiz, A., Bober, E. & Butukgbiz, B. (1997) Vitamin A and beta caroten levels in constitutional delay of growth and puberty. Journal of Pediatric Endocrinology and Metabolism, 10, 51-54.
6. Cameron, J.L. (1996) Nutritional determinates of puberty. Nutrition Review, 54 (Suppl.), 17-22.
7. Castillo-Duran, C., Carcia, H., Venegas, P., Torrealba, I., Panteon, E., Concha, N. & Perez, P. (1994) Zinc supplementation increases growth velocity of male children and adolescents with short stature. Acta Paediatrica, 83, 833-837.
8. Chambon, P. (1993) The molecular and genetic dissection of the retinoid signalling pathway. Gene, 135, 223-225.
9. Cho, S., Cho, H., Geum, D. & Kim, K. (1998) Retinoic acid regulates gonadotropin-releasing hormone (GnRH) release and gene expression in the rat hypothalamic fragment and GT1-1 neural cells in vitro. Brain Research Molecular Brain Research, 54, 74-84.
10. Choe, Y.H., Kim, S.K. & Hong, Y.C. (2000) Helicobacter pylori infection with iron deficiency anemia and subnormal growth at puberty. Archives of Disease in Childhood, 82, 136-140.
11. Couzinet, B., Young, J., Brailly, S., Le Booc, Y., Chanson, P. & Schaison, G. (1999) Functional hypothalamic amenorrhoea: a partial and reversible gonadotropin deficiency of nutritional origin. Clinical Endocrinology, 50, 229-235.
12. De Luca, F., Argente, J., Cavallo, L. Crowne, E. Delemarre-Van de Waal, H.A., De Sanctis, C., Di Maio, S., Norjavaara, E., Oostdijk, W., Severi, F., Tonini, G., Trifiro, G., Voorhoeve, P.G., & Wu, F. (2001) International Workshop on Management of Puberty for Optimum Auxological Results. Management of puberty in constitutional delay of growth and puberty. Journal of Pediatrics Endocrinology and Metabolism, 14 (Suppl.), 953-957.
13. Djakoure, C., Guibourdenche, J., Porquet, D., Pagesy, P., Peillon, F., Li, J.Y. & Evain-Brion, D. (1996) Vitamin A and retinoic acid stimulates within minutes cAMP release and growth hormone secretion in human pituitary cells. Journal of Clinical Endocrinology and Metabolism, 81, 3123-3126.
14. Evain Brion, D., Porqnet, P., Therond, P., Fjellestad-Paulsen, A., Greneche, M.O., Francois, L. & Czernichow, P. (1994) Vitamin A deficiency and nocturnal growth hormone secration in short children. Lancet, 343, 87-88.
15. Finkelstein, J.S., Klibanski, A. & Neer, R.M. (1996) A longitudinal evaluation of bone mineral density in adult men with histories of delayed puberty. Journal of Clinical Endocrinology and Metabolism, 81, 1152-1155.
16. Fuchs, G.J., Ausayakhun, S., Ruckphaopunt, S., Tansuhai, A. & Suskind, R.M. (1994) Relationship betweemn vitamin A deficiency, malnutrition, and conjuctivital impression cytology. American Journal of Clinical Nutrition, 60, 293-298.
17. Greneche, M.O., Francois, L., Fjellstad-Paulsen, A. & Evain-Brion, D. (1996) Evaluation of dietary vitamin A intake in children with and without growth retardation. Archives of Pediatrics, 3, 847-853.
18. Greulich, W.W. & Pyle, S.I. (1959) Radiographic Atlas of Skeletal Development of the Hand and Wrist. Stanford University Press, Stanford.
19. Guibourdenche, J., Djakoure, C., Porquet, D., Pagesy, P., Rochette-Egly, C., Peillon, F., Li, J.Y. & Evain-Brion, D. (1997) Retinoic acid stimulates growth hormone synthesis in human somatotropic adenoma cells: characterization of its nuclear receptors. Journal of Cell Biochemistry, 65, 25-31.
20. Hamill, P.V.V., Drizd, T.A., Johnson, C.L., Reed, R.B., Roche, A.F. & Moore, W.M. (1979) Physical growth: National Center for Health statistics percentiles. American Journal of Clinical Nutrition, 32, 607-629.
21. Layrisse, M., Carcia-Casal, M.N., Solano, L., Baron, M.A., Arguello, F., Llovera, D., Ramirez, J., Leets, I. & Tropper, E. (2000) New property of vitamin A and beta-carotene on human iron absorption. Effect on phytate and polyphenols as inhibitors of iron absorption. Archives of Latin American Nutrition, 50, 243-248.
22. Lee, P.D.K. & Rosenfeld, R.G. (1987) Psychosocial correlates of short stature and delayed puberty. Pediatric and Adolescent Endocrinology, 4, 851-863.
23. Livera, G., Rouiller-Fabre, V., Durand, P. & Habert, R. (2000) Multiple effects of retinoids on the development of sertoli, germ, and leydig cells of fetal and neonatal rat testis in culture. Biological Reproduction, 62, 1303-1314.
24. Munoz, E.C., Rosado, J.L., Lopez, P., Furr, H.C. & Allen, L.H. (2000) Iron and zinc supplementation improves indicators of vitamin A status of Mexican preschoolers. American Journal of Clinical Nutrition, 71, 789-794.
25. Reifen, R., Altman, Y. & Zadik, Z. (1996) Vitamin A levels and growth hormone axis. Hormone Research, 46, 279-281.
26. Reifen, R. & Wasantwisut, E. (1998) Vitamin A in pediatric nutrition. In: Advances in Pediatric Nutrition (eds R. Reifen, A. Lerner, D. Branski & H. Heymans). Karger, Basel.
27. Reifen, R., Zaiger, G. & Uni, Z. (1988) Effect of vitamin A deficiency on small intestinal brush border enzymes in a rat model. International Journal of Vitaminological Research, 68, 281-286.
28. Metges, C.C. & Barth, C.A. (2000) Metabolic consequences of a high dietary protein intake in adulthood assessment of the available evidence. Journal of Nutrition, 130, 886-889.
29. Solans, C.V. & Lifshitz, F. (1992) Body weight progression and nutritional status of patients with familial short stature with and without constitutional delay in growth. American Journal of Disease Child, 146, 296-302.
30. Soliman, A.T., Khadir, M.M. & Asfour, M. (1995) Testosterone treatment in adolescent boys with constitutional delay of growth and development. Metabolism, 44, 1013-1015.
31. Tanner, J.M. (1962) Growth at Adolescence, 2nd edn. Blackwell Scientific Publications, Oxford.
32. Vihenrvuori, E. Sipilia, I. & Siimes, M.A. (1994) Increases in hemoglobin concentration and iron needs in response to growth hormone treatment. Journal of Pediatrics, 125, 242-245.
33. Wilson, D.M., McCauley, E., Brown, D.R. & Dudley, R. (1995) Oxandrolone therapy in constitutionally delayed growth and puberty. Bio-technology General Corporation Cooperative Study Group. Pediatrics, 96, 1095-1100.
34. Zadik, Z., Chalew, S.A. McCarter, R.J. Jr, Meistas, M. & Kowarski, A.A. (1985) The influence of age on the 24-hour integrated concentration of growth hormone in normal individuals. Journal of Clinical Endocrinology and Metabolism, 60, 513-518.