Purifying selection masks the mutational flexibility of HIV-1 reverse transcriptase

Journal of Biological Chemistry

Volumn 279, Issue 25, 2004, Pages 26726-26734

  Smith, Robert A ^a   Anderson, Donovan J ^a   Preston, Bradley D ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Box 357705 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; DNA; MUTAGENESIS; RNA;

MUTATIONAL FLEXIBILITY; REVERSE TRANSCRIPTASE (RT);

BIOCHEMISTRY;

DNA POLYMERASE; LAMIVUDINE; NUCLEOSIDE ANALOG; RNA DIRECTED DNA POLYMERASE; RNA POLYMERASE; ZIDOVUDINE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; DELETION MUTANT; DRUG SENSITIVITY; ENZYME STRUCTURE; GENETIC CONSERVATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN MOTIF; RETROVIRUS; VIRUS CULTURE; VIRUS INFECTIVITY; VIRUS REPLICATION; WILD TYPE;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACIDS; ANTI-RETROVIRAL AGENTS; CELL LINE; CLONING, MOLECULAR; CONSERVED SEQUENCE; DNA MUTATIONAL ANALYSIS; GENETIC TECHNIQUES; HELA CELLS; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; LAMIVUDINE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTATION; PLASMIDS; PROTEIN CONFORMATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY, AMINO ACID; VARIATION (GENETICS); VIRUS REPLICATION; ZIDOVUDINE;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES; UNIDENTIFIED RETROVIRUS;

EID: 2942726271     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M314038200     Document Type: Article

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