Optimization of the signal-to-noise ratio of frequency-domain instrumentation for near-infrared spectro-imaging of the human brain

Optics Express

Volumn 11, Issue 21, 2003, Pages 2717-2729

  Toronov, Vlad ^a   D'Amico, Enrico ^b   Hueber, Dennis ^c   Gratton, Enrico ^b   Barbieri, Beniamino ^c   Webb, Andrew ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b United States of America   (United States)

^c ISS Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOTECHNOLOGY; BRAIN; COMPUTER SIMULATION; LIGHT SOURCES; MODULATION; MONTE CARLO METHODS; PHOTONS; SIGNAL TO NOISE RATIO;

MEDICAL OPTICS; PHOTON DENSITY WAVES; PHOTON MIGRATION;

INFRARED IMAGING;

EID: 2942722438     PISSN: 10944087     EISSN: None     Source Type: Journal    
DOI: 10.1364/OE.11.002717     Document Type: Article

References (12)

1. A. Villringer, J. Planck, C. Hock, L. Schleinkofer, U. Dimagl, "Near infrared spectroscopy (NIRS): a new tool to study hemodynamic changes during activ ation of brain function in human adults," Neurosci. Lett. 154, 101-104 (1993).
2. R.M. Danen, Y.Wang, X.D. Li, W.S.Thayer, A.G. Yodh., "Regional imager for low-resolution functional imaging of the brain with diffusing new infrared light," Photochem Photobiol 67, 3340 (1998).
3. C.D. Kurth and W.S. Thayer, "A multiwavelength frequency-domain near-infrared cerebral oximeters," Phys. Med. Biol. 44, 727-740 (1999).
4. V. Toronov, A. Webb, J. H. Choi, M. Wolf, L. Safonova, U. Wolf, E. Gratton. "Study of Local Cerebral Hemodynamic Fluctuations by Simultaneous Frequency-Domain near-infrared spectroscopy and fMRI," Optics Express 9, 417-427 (2001), http://www.opticsexpress.org/abstract.cfm?URI=OPEX-9-8-417.
5. V. Toronov, A. Webb, S. Walker, R. Gupta, J. H. Choi, E. Gratton, D. Hueber, "The Roles of Changes in Deoxyhemoglobin Concentration and Blood Volume in the fMRI BOLD Signal," Neuroimagc 19, 1521-31 (2003).
6. G. Alexandrakis, T.J. Farrell, and M. S. Patterson, "Accuracy of the diffusion approximation in determining the optical properties of a two-layer turbid medium," Appl. Opt. 37, 7401-7409 (1998).
7. D. A. Boas, M. A. OLeary, B. Chance, A. G. Yodh, "Detection and characterization of optical inhomogeneities with diffuse photon density waves: a signal-to-noise analysis," Appl. Opt. 36, 75-92 (1997)
8. I.G. Zubal, C.R. Harrell, E.O. Smith, Z. Rattner, G. Gindi, P.B.Hoffer, "Computerized 3-Dimensional Segmented Human Anatomy," Med. Phys. 21, 299-302 (1994), http://noodle.med.yale.edu/zubal/.
9. Y. Chen, C. Mu, X. Intes, B. Chance, "Signal-to-noise analysis for detection sensitivity of small absorbing heterogeneity in turbid media with single-source and dual-interfering-source," Opt. Express 9, 212-224 (2001), http://www.opticsexpress.org/abstract.cfm?URI-OPEX-9-4-212.
10. D.A. Boas, J. P. Culver, J. J. Stott, and A. K. Dunn, "Three dimensional Monte Carlo code for photon migration through complex heterogeneous media including the adult human head," Opt. Express 10, 159-170 (2002), http://www.opticsexpress.org/abstract.cfm?URI=OPEX-10-3-159.
11. J. H. Choi, M. Wolf, V. Toronov, U. Wolf, C. Polzonetti, D. Hueber, L. Safonova, R. Gupta, A. Michalos, W. Mantulin, E. Gratton, "Noninvasive determination of absolute optical properties of adult human brain: near infrared spectroscopy approach," J. Biomed. Opt. (in press)
12. M. Firbank, E. Okada, D.T. Delpy, "A theoretical study of the signal contribution of regions of the adult head to near infrared spectroscopy studies of visual evoked responses," Neuroimage 8, 69-78 (1998).