Ketamine blocks non-N-methyl-D-aspartate receptor channels attenuating glutamatergic transmission in the auditory cortex

Acta Oto-Laryngologica

Volumn 124, Issue 4, 2004, Pages 454-458

  Leong, Darrell ^a   Puil, Ernest ^a   Schwarz, Dietrich ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Action potentials; Cortical network; Excitatory post synaptic potentials; Neurons; Synaptic transmission

Indexed keywords

6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; GLUTAMATE RECEPTOR; GLUTAMIC ACID; KETAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AUDITORY CORTEX; AUDITORY STIMULATION; CAPSULA INTERNA; CONFERENCE PAPER; ELECTROSTIMULATION; EVOKED AUDITORY RESPONSE; EXCITATORY POSTSYNAPTIC POTENTIAL; GABAERGIC SYSTEM; GABAERGIC TRANSMISSION; MEMBRANE RESISTANCE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RECEPTOR BLOCKING; SYNAPTIC TRANSMISSION; TECHNIQUE;

ACTION POTENTIALS; ANESTHETICS, DISSOCIATIVE; ANIMALS; AUDITORY CORTEX; DEPRESSION, CHEMICAL; ELECTRIC STIMULATION; GERBILLINAE; KETAMINE; MEMBRANE POTENTIALS; RECEPTORS, GLUTAMATE; RECEPTORS, N-METHYL-D-ASPARTATE; SYNAPTIC TRANSMISSION;

EID: 2942708199     PISSN: 00016489     EISSN: None     Source Type: Journal    
DOI: 10.1080/0001648031000692     Document Type: Conference Paper

References (16)

1. Evers AS, Crowder CM. General anesthetics. In: Hardman JG, Limbird LE, Gilman AG, editors. Goodman & Gilman's the pharmacological basis of therapeutics. New York: McGraw-Hill; 2001. p. 337-65.
2. Kress HG. Wirkungsmechanismen von Ketamin. Anaesthesist 1997; 46: S8-19.
3. MacDonald JF, Miljkovic Z, Pennefather P. Use-dependent block of excitatory amino acid currents in cultured neurons by ketamine. J Neurophysiol 1987; 58: 251-66.
4. Yamamura T, Harada K, Okamura A, Kemmotsu O. Is the site of action of ketamine anesthesia the N-methyl-D-aspartate receptor? Anesthesiology 1990; 72: 704-10.
5. Plourde G, Baribeau J, Bonhomme V. Ketamine increases the amplitude of the 40-Hz auditory steady-state response in humans. Br J Anaesth 1997; 78: 524-9.
6. Budinger E, Heil P, Scheich H. Functional organization of auditory cortex in the Mongolian gerbil (Meriones unguiculatus). IV. Connections with anatomically characterized subcortical structures. Eur J Neurosci 2000; 12: 2452-74.
7. Connors BW, Gutnick MJ, Prince DA. Electrophysiological properties of neocortical neurons in vitro. J Neurophysiol 1982; 48: 1302-20.
8. Connors BW, Gutnick MJ. Intrinsic firing patterns of diverse neocortical neurons. Trends Neurosci 1990; 13: 99-104.
9. McCormick DA, Connors BW, Lighthall JW, Prince DA. Comparative electrophysiology of pyramidal and sparsely spiney stellate neurons of the neocortex. J Neurophysiol 1985; 54: 782-806.
10. MacDonald JF, Mody I, Salter MW. Regulation of N-methyl-D-aspartate receptors revealed by intracellular dialysis of murine neurons in culture. J Physiol 1989; 414: 17-34.
11. MacDonald JF, Nowak LM. Mechanisms of blockade of excitatory amino acid receptor channels. Trends Pharmacol 1990; 11: 167-72.
12. + channels. Eur J Anaesthesiol 2001; 18: 177-83.
13. Gage PW, Robertson B. Prolongation of inhibitory postsynaptic currents by pentobarbitone, halothane and ketamine in CA1 pyramidal cells in rat hippocampus. Br J Pharmacol 1985; 85: 675-81.
14. Oshima E, Richards CD. An in-vitro investigation of the action of ketamine on excitatory transmission in the hippocampus of the guinea pig. Eur J Pharmacol 1988; 148: 23-33.
15. Cohen ML, Chan SL, Way WL, Trevor AJ. Distribution in the brain and metabolism of ketamine in the rat after intravenous administration. Anesthesiology 1973; 39: 370-6.
16. Honey CR, Miljkovic Z, MacDonald JF. Ketamine and phencyclidine cause a voltage-dependent block of responses to 1-aspartic acid. Neurosci Lett 1985; 61: 135-9.