Inhibition of insulin synthesis by cyproheptadine: Effects on translation

Toxicological Sciences

Volumn 79, Issue 2, 2004, Pages 258-265

  Hawkins, Belinda S ^a,b   Fischer, Lawrence J ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Cyproheptadine; Insulin synthesis; mRNA; Preproinsulin; RINm5F cells

Indexed keywords

ANTIHISTAMINIC AGENT; BINDING PROTEIN; CYPROHEPTADINE; INITIATION FACTOR 2; INITIATION FACTOR 2ALPHA; INITIATION FACTOR 4E; INITIATION FACTOR 4E BINDING PROTEIN; INSULIN; MESSENGER RNA; PREPROINSULIN; SEROTONIN ANTAGONIST; UNCLASSIFIED DRUG;

ARTICLE; CELL FRACTIONATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETOGENESIS; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; ENDOPLASMIC RETICULUM; IN VITRO STUDY; IN VIVO STUDY; INSULIN SYNTHESIS; POLYSOME; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RIBOSOME; RNA TRANSLATION; TRANSLATION INITIATION;

ANIMALS; CELL FRACTIONATION; CELL LINE, TUMOR; CYPROHEPTADINE; ENDOPLASMIC RETICULUM; EUKARYOTIC INITIATION FACTOR-2; EUKARYOTIC INITIATION FACTOR-4E; INSULIN ANTAGONISTS; PHOSPHORYLATION; PIPERIDINES; PROINSULIN; PROTEIN BIOSYNTHESIS; PROTEIN PRECURSORS; RATS; RNA, MESSENGER; TIME FACTORS;

ANIMALIA;

EID: 2942704247     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfh113     Document Type: Article

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