Relationship between CD8+ T-cell phenotype and function, Epstein-Barr virus load, and clinical outcome in pediatric renal transplant recipients: A prospective study

Transplantation

Volumn 77, Issue 11, 2004, Pages 1706-1713

  Baudouin, Véronique ^a   Dehée, Axelle ^b   Pédron Grossetete, Béatrice ^a   Ansart Pirenne, Hélène ^a   Haddad, Elie ^a   Maisin, Anne ^a   Loirat, Chantal ^a   Sterkers, Ghislaine ^a  

^a HÔPITAL ROBERT DEBRÉ   (France)

^b ARMAND TROUSSEAU HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; AZATHIOPRINE; BASILIXIMAB; CD28 ANTIGEN; CD3 ANTIGEN; CD8 ANTIGEN; CYCLOSPORIN A; HLA DR ANTIGEN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; STEROID; THYMOCYTE ANTIBODY;

ADOLESCENT; ARTICLE; CELL DIFFERENTIATION; CHILD; CLINICAL ARTICLE; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; EFFECTOR CELL; EPSTEIN BARR VIRUS; FEMALE; GENE AMPLIFICATION; HUMAN; KIDNEY TRANSPLANTATION; LONGITUDINAL STUDY; LYMPHOPROLIFERATIVE DISEASE; MALE; MEMORY CELL; OUTCOMES RESEARCH; PHENOTYPE; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RETROSPECTIVE STUDY; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; VIRUS INFECTION; VIRUS LOAD;

ADOLESCENT; CD8-POSITIVE T-LYMPHOCYTES; CHILD; CHILD, PRESCHOOL; EPSTEIN-BARR VIRUS INFECTIONS; FEMALE; HERPESVIRUS 4, HUMAN; HUMANS; INFANT; KIDNEY TRANSPLANTATION; LYMPHOPROLIFERATIVE DISORDERS; MALE; PHENOTYPE; POSTOPERATIVE COMPLICATIONS; PROSPECTIVE STUDIES; TREATMENT OUTCOME; VIRAL LOAD;

EID: 2942685333     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.TP.0000131168.21930.5C     Document Type: Article

References (24)

1. Cohen JI. Epstein-Barr virus infection. N Engl J Med 2000; 343: 481.
2. Tomkinson BE, Wagner DK, Nelson DL, et al. Activated lymphocytes during acute Epstein-Barr virus infection. J Immunol 1987; 139: 3802.
3. Altman JD, Moss PA, Goulder PJ, et al. Phenotypic analysis of antigen-specific T lymphocytes. Science 1996; 274: 94.
4. Lynne JE, Schmid I, Matud JL, et al. Major expansions of select CD8+ subsets in acute Epstein-Barr virus infection: Comparison with chronic human immunodeficiency virus disease. J Infect Dis 1998; 177: 1083.
5. Callan MF, Steven N, Krausa P, et al. Large clonal expansions of CD8+ T cells in acute infectious mononucleosis. Nat Med 1996; 2: 906.
6. Silins SL, Sherritt MA, Silleri JM, et al. Asymptomatic primary Epstein-Barr virus infection occurs in the absence of blood T-cell repertoire perturbations despite high levels of systemic viral load. Blood 2001; 98: 3739.
7. Callan MF, Tan L, Annels N, et al. Direct visualization of antigen-specific CD8+ T cells during the primary immune response to Epstein-Barr virus in vivo. J Exp Med 1998; 187: 1395.
8. Rooney CM, Smith CA, Ng CY, et al. Use of gene-modified virus-specific T lymphocytes to control Epstein-Barr-virus-related lymphoproliferation. Lancet 1995; 345: 9.
9. Heslop HE, Ng CY, Li C, et al. Long-term restoration of immunity against Epstein-Barr virus infection by adoptive transfer of gene-modified virus-specific T lymphocytes. Nat Med 1996; 2: 551.
10. Boyle TJ, Berend KR, DiMaio JM, et al. Adoptive transfer of cytotoxic T lymphocytes for the treatment of transplant-associated lymphoma. Surgery 1993; 114: 218.
11. Savoie A, Perpete C, Carpentier L, et al. Direct correlation between the load of Epstein-Barr virus-infected lymphocytes in the peripheral blood of pediatric transplant patients and risk of lymphoproliferative disease. Blood 1994; 83: 2715.
12. Mutimer D, Kaur N, Tang H, et al. Quantitation of Epstein-Barr virus DNA in the blood of adult liver transplant recipients. Transplantation 2000; 69: 954.
13. Lucas KG, Filo F, Heilman DK, et al. Semiquantitative Epstein-Barr virus polymerase chain reaction analysis of peripheral blood from organ transplant patients and risk for the development of lymphoproliferative disease. Blood 1998; 92: 3977.
14. Kenagy DN, Schlesinger Y, Weck K, et al. Epstein-Barr virus DNA in peripheral blood leukocytes of patients with posttransplant lymphoproliferative disease. Transplantation 1995; 60: 547.
15. Green M, Cacciarelli TV, Mazariegos GV, et al. Serial measurement of Epstein-Barr viral load in peripheral blood in pediatric liver transplant recipients during treatment for posttransplant lymphoproliferative disease. Transplantation 1998; 66: 1641.
16. Stevens SJ, Verschuuren EA, Pronk I, et al. Frequent monitoring of Epstein-Barr virus DNA load in unfractionated whole blood is essential for early detection of posttransplant lymphoproliferative disease in high-risk patients. Blood 2001; 97: 1165.
17. Crawford DH, Sweny P, Edwards JM, et al. Long-term T-cell-mediated immunity to Epstein-Barr virus in renal-allograft recipients receiving cyclosporin A. Lancet 1981; 1: 10.
18. Gaston JS, Rickinson AB, Epstein MA. Epstein-Barr-virus-specific T-cell memory in renal-allograft recipients under long-term immunosuppression. Lancet 1982; 1: 923.
19. Smets F, Latinne D, Bazin H, et al. Ratio between Epstein-Barr viral load and anti-Epstein-Barr virus specific T-cell response as a predictive marker of posttransplant lymphoproliferative disease. Transplantation 2002; 73: 1603.
20. Yoshimi A, Tsuge I, Namizaki H, et al. Epstein-Barr virus-specific T-cell cytotoxicity is mediated through the perforin pathway in patients with lymphoproliferative disorders after allogeneic bone marrow transplantation. Br J Haematol 2002; 116: 710.
21. Kuzushima K, Kimura H, Hoshino Y, et al. Longitudinal dynamics of Epstein-Barr virus-specific cytotoxic T lymphocytes during posttransplant lymphoproliferative disorder. J Infect Dis 2000; 182: 937.
22. Ho M, Miller G, Atchison RW, et al. Epstein-Barr virus infections and DNA hybridization studies in posttransplantation lymphoma and lymphoproliferative lesions: The role of primary infection. J Infect Dis 1985; 152: 876.
23. Ho M, Jaffe R, Miller G, et al. The frequency of Epstein-Barr virus infection and associated lymphoproliferative syndrome after transplantation and its manifestations in children. Transplantation 1988; 45: 719.
24. Rooney CM, Loftin SK, Holladay MS, et al. Early identification of Epstein-Barr virus-associated post-transplantation lymphoproliferative disease. Br J Haematol 1995; 89: 98.