Chemoradiation with 5-fluorouracil and mitomycin C in the treatment of vulvar squamous cell carcinoma

Gynecologic Oncology

Volumn 93, Issue 3, 2004, Pages 659-666

  Mulayim, Naciye ^a   Silver, David Foster ^b   Schwartz, Peter E ^a   Higgins, Susan ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

Author keywords

5 Fluorouracil; Chemoradiation; Mitomycin C; Toxicity; Vulvar cancer

Indexed keywords

FLUOROURACIL; MITOMYCIN C;

ACUTE TOXICITY; ADULT; AGED; ARTICLE; BLOOD TOXICITY; CANCER ADJUVANT THERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CAUSE OF DEATH; CELLULITIS; CHEMOTHERAPY INDUCED EMESIS; CLINICAL ARTICLE; DEHYDRATION; DIARRHEA; DISEASE SEVERITY; DRUG FATALITY; ENTEROCOLITIS; FATIGUE; FEBRILE NEUTROPENIA; FEMALE; FOLLOW UP; GASTROINTESTINAL SYMPTOM; GASTROINTESTINAL TOXICITY; HEARING LOSS; HUMAN; INTESTINE PERFORATION; MEDICAL RECORD; MORBIDITY; MOUTH INFLAMMATION; MUCOSA INFLAMMATION; NAUSEA; NEUTROPENIA; OROPHARYNX; OTOTOXICITY; PAIN; PANCYTOPENIA; PHARYNX DISEASE; PRIORITY JOURNAL; RADIATION DOSE; RADIATION INJURY; SALVAGE THERAPY; SCORING SYSTEM; SEPSIS; SIDE EFFECT; SKIN TOXICITY; SQUAMOUS CELL CARCINOMA; THROMBOCYTE TRANSFUSION; THROMBOCYTOPENIA; TREATMENT OUTCOME; VULVA CARCINOMA; WEIGHT REDUCTION;

AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, SQUAMOUS CELL; CHEMOTHERAPY, ADJUVANT; DRUG ADMINISTRATION SCHEDULE; FEMALE; FLUOROURACIL; HUMANS; MIDDLE AGED; MITOMYCIN; NEOPLASM STAGING; RADIOTHERAPY; RADIOTHERAPY, ADJUVANT; SALVAGE THERAPY; VULVAR NEOPLASMS;

EID: 2942670573     PISSN: 00908258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ygyno.2004.03.019     Document Type: Article

References (20)

1. Jemal A., Murray T., Samuels A., Ghafoor A., Ward E., Thun M.J. Cancer statistics. CA Cancer J. Clin. 53(1):2003;5-26
2. Eifel P.J., Morris M., Burke T.W., Levenback C., Gershenson D.M. Prolonged continuous infusion cisplatin and 5-fluorouracil with radiation for locally advanced carcinoma of the vulva. Gynecol. Oncol. 59(1):1995;51-56
3. Landoni F., Maneo A., Zanetta G., Colombo A., Nava S., Placa F., et al. Concurrent preoperative chemotherapy with 5-fluorouracil and mitomycin C and radiotherapy (FUMIR) followed by limited surgery in locally advanced and recurrent vulvar carcinoma. Gynecol. Oncol. 61(3):1996;321-327
4. Lupi G., Raspagliesi F., Zucali R., Fontanelli R., Paladini D., Kenda R., et al. Combined preoperative chemoradiotherapy followed by radical surgery in locally advanced vulvar carcinoma. A pilot study. Cancer. 77(8):1996;1472-1478
5. Cunningham M.J., Goyer R.P., Gibbons S.K., Kredentser D.C., Malfetano J.H., Keys H. Primary radiation, cisplatin, and 5-fluorouracil for advanced squamous carcinoma of the vulva. Gynecol. Oncol. 66(2):1997;258-261
6. Moore D.H., Thomas G.M., Montana G.S., Saxer A., Gallup D.G., Olt G. Preoperative chemoradiation for advanced vulvar cancer: a phase II study of the Gynecologic Oncology Group. Int. J. Radiat. Oncol. Biol. Phys. 42(1):1998;79-85
7. Han S.C., Kim D.H., Higgins S.A., Carcangiu M.L., Kacinski B.M. Chemoradiation as primary or adjuvant treatment for locally advanced carcinoma of the vulva. Int. J. Radiat. Oncol. Biol. Phys. 47(5):2000;1235-1244
8. Akl A., Akl M., Boike G., Hebert J., Graham J. Preliminary results of chemoradiation as a primary treatment for vulvar carcinoma. Int. J. Radiat. Oncol. Biol. Phys. 48(2):2000;415-420
9. Bartelink H., Roelofsen F., Eschwege F., Rougier P., Bosset J.F., Gonzalez D.G., et al. Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: results of a phase III randomized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and Gastrointestinal Cooperative Groups. J. Clin. Oncol. 15(5):1997;2040-2049
10. Flam M., John M., Pajak T.F., Petrelli N., Myerson R., Doggett S., et al. Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: results of a phase III randomized intergroup study. J. Clin. Oncol. 14(9):1996;2527-2539
11. Epidermoid anal cancer: results from the UKCCCR randomised trial of radiotherapy alone versus radiotherapy, 5-fluorouracil, and mitomycin. UKCCCR Anal Cancer Trial Working Party. UK Co-ordinating Committee on Cancer Research. Lancet. 348(9034):1996;1049-1054
12. Kalend A.M., Park T.L., Wu A., Kalnicki S., Meek A.G., Bloomer W.D., et al. Clinical use of a wing field with transmission block for the treatment of the pelvis including the inguinal node. Int. J. Radiat. Oncol. Biol. Phys. 19(1):1990;153-158
13. Trotti A., Byhardt R., Stetz J., Gwede C., Corn B., Fu K., et al. Common toxicity criteria: version 2.0. An improved reference for grading the acute effects of cancer treatment: impact on radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 47(1):2000;13-47
14. Nigro N.D., Seydel H.G., Considine B., Vaitkevicius V.K., Leichman L., Kinzie J.J. Combined preoperative radiation and chemotherapy for squamous cell carcinoma of the anal canal. Cancer. 51(10):1983;1826-1829
15. Levin W., Goldberg G., Altaras M., Bloch B., Shelton M.G. The use of concomitant chemotherapy and radiotherapy prior to surgery in advanced stage carcinoma of the vulva. Gynecol. Oncol. 25(1):1986;20-25
16. Koh W.J., Wallace H.J. III, Greer B.E., Cain J., Stelzer K.J., Russell K.J., et al. Combined radiotherapy and chemotherapy in the management of local-regionally advanced vulvar cancer. Int. J. Radiat. Oncol. Biol. Phys. 26(5):1993;809-816
17. Rakovitch E., Fyles A.W., Pintilie M., Leung P.M. Role of mitomycin C in the development of late bowel toxicity following chemoradiation for locally advanced carcinoma of the cervix. Int. J. Radiat. Oncol. Biol. Phys. 38(5):1997;979-987
18. Toxicity of fluorouracil in patients with advanced colorectal cancer: effect of administration schedule and prognostic factors. Meta-analysis group in cancer. J. Clin. Oncol. 16(11):1998;3537-3541
19. Tebbutt N.C., Norman A.R., Cunningham D., Allen M., Chau I., Oates J., et al. Analysis of the time course and prognostic factors determining toxicity due to infused fluorouracil. Br. J. Cancer. 88(10):2003;1510-1515
20. Hung A., Crane C., Delclos M., Ballo M., Ajani J., Lin E., et al. Cisplatin-based combined modality therapy for anal carcinoma: a wider therapeutic index. Cancer. 97(5):2003;1195-1202