Best linear unbiased allele-frequency estimation in complex pedigrees

Biometrics

Volumn 60, Issue 2, 2004, Pages 359-367

  McPeek, Mary Sara ^a,b   Wu, Xiaodong ^a,b,c   Ober, Carole ^b  

^a University of Chicago   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

Allele frequency estimation; BLUE; BLUP; Complex pedigree; Quasi likelihood

Indexed keywords

GENES; MAXIMUM LIKELIHOOD ESTIMATION; MEAN SQUARE ERROR; POPULATION STATISTICS;

ALLELE-FREQUENCY ESTIMATION; BEST LINEAR UNBIASED ESTIMATOR; BLUP; COMPLEX PEDIGREE; GENETIC ANALYSIS; MAXIMUM LIKELIHOOD ESTIMATOR; MAXIMUM-LIKELIHOOD ESTIMATION; QUASI-LIKELIHOOD; SMALL SAMPLES; UNBIASED ESTIMATOR;

FREQUENCY ESTIMATION;

ALLELE;

ALGORITHM; ALLELE; ANALYTIC METHOD; ARTICLE; BEST LINEAR UNBIASED ESTIMATOR; GENE FREQUENCY; GENETIC ANALYSIS; GENOTYPE; HUMAN; MAXIMUM LIKELIHOOD METHOD; PEDIGREE;

EID: 2942655651     PISSN: 0006341X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0006-341X.2004.00180.x     Document Type: Article

References (21)

1. Abney, M., McPeek, M. S., and Ober, C. (2000). Estimation of variance components of quantitative traits in inbred populations. American Journal of Human Genetics 66, 629-650.
2. Abney, M., Ober, C., and McPeek, M. S. (2002). Quantitative trait homozygosity and association mapping and empirical genome-wide significance in large complex pedigrees: Fasting serum insulin level in the Hutterites. American Journal of Human Genetics 70, 920-934.
3. Boehnke, M. (1991). Allele frequency estimation from data on relatives. American Journal of Human Genetics 48, 22-25.
4. Bourgain, C., Hoffjan, S., Nicolae, R., Newman, D., Steiner, L., Walker, K., Reynolds, R., Ober, C., and McPeek, M. S. (2003). Novel case-control test in a founder population identifies P-selectin as an atopy susceptibility locus. American Journal of Human Genetics 73, 612-626.
5. Boyce, A. J. (1983). Computation of inbreeding and kinship coefficients on extended pedigrees. Journal of Heredity 74, 400-404.
6. Broman, K. W. (2001). Estimation of allele frequencies with data on sibships. Genetic Epidemiology 20, 307-315.
7. Ceppellini, R., Siniscalco, M., and Smith, C. A. B. (1955). The estimation of gene frequencies in a random mating population. Annals of Human Genetics, London 20, 97-115.
8. Chakraborty, R. (1978). Number of independent genes examined in family surveys and its effect on gene frequency estimation. American Journal of Human Genetics 30, 550-552.
9. Cotterman, C. W. (1947). A weighting system for the estimation of gene frequencies from family records. Contributions from the Laboratory of Vertebrate Biology 33, 1-21.
10. Finney, D. J. (1948a). The estimation of gene frequencies from family records. I. Factors without dominance. Heredity 2, 199-218.
11. Finney, D. J. (1948b). The estimation of gene frequencies from family records. II. Factors with dominance. Heredity 2, 369-390.
12. Fisher, R. A. (1940). The estimation of the proportion of recessives from tests carried out on a sample not wholly unrelated. Annals of Eugenics 10, 160-170.
13. Graybill, F. A. (1976). Theory and Application of the Linear Model. North Scituate, Massachusetts: Duxbury Press.
14. Lange, K., Weeks, D., and Boehnke, M. (1988). Programs for pedigree analysis: MENDEL, FISHER, and dGENE. Genetic Epidemiology 5, 471-472.
15. Lehmann, E. L. and Casella, G. (1998). Theory of Point Estimation, 2nd edition. New York: Springer.
16. Lockwood, J. R., Roeder, K., and Devlin, B. (2001). A Bayesian hierarchical model for allele frequencies. Genetic Epidemiology 20, 17-33.
17. McCullagh, P. and Nelder, J. A. (1989). Generalized Linear Models, 2nd edition. New York: Chapman and Hall.
18. Ober, C., Abney, M., and McPeek, M. S. (2001). The genetic dissection of complex traits in a founder population. American Journal of Human Genetics 69, 1068-1079.
19. Olson, J. M. (1994). Robust estimation of gene frequency and association parameters. Biometrics 50, 665-674.
20. Ott, J. (1992). Strategies for characterizing highly polymorphic markers in human gene mapping. American Journal of Human Genetics 51, 283-290.
21. Wedderburn, R. W. M. (1974). Quasi-likelihood functions, generalized linear models, and the Gauss-Newton method. Biometrika 61, 439-447.