Synthesis of new pyrido[4,3-g and 3,4-g]quinoline-5,10-dione and dihydrothieno[2,3-g and 3,2-g]quinoline-4,9-dione derivatives and preliminary evaluation of cytotoxic activity

Arkivoc

Volumn 2004, Issue 5, 2004, Pages 85-96

  Gomez Monterrey, Isabel ^a   Campiglia, Pietro ^a   Lama, Teresa ^a   La Colla, Paolo ^b   Diurno, Maria V ^a   Grieco, Paolo ^a   Novellino, Ettore ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Cytotoxic agents; MT 4 cell line; Quinolinedione derivatives

Indexed keywords

3 (2' IODOPHENYLCARBONYL)AMINO 3 ETHOXYCARBONYL 2,3 DIHYDROTHIENO[2,3 G]QUINOLINE 4,9 DIONE; 3 (2' IODOPHENYLCARBONYL)AMINO 3 ETHOXYCARBONYL 2,3 DIHYDROTHIENO[3,2 G]QUINOLINE 4,9 DIONE; 3 (3' FLUOROPHENYLCARBONYL)AMINO 3 ETHOXYCARBONYL 2,3 DIHYDROTHIENO[2,3 G]QUINOLINE 4,9 DIONE; 3 (3' FLUOROPHENYLCARBONYL)AMINO 3 ETHOXYCARBONYL 2,3 DIHYDROTHIENO[3,2 G]QUINOLINE 4,9 DIONE; 3 (PHENYLALANYL)AMINO 3 ETHOXYCARBONYL 2,3 DIHYDROTHIENO[2,3 G]QUINOLINE 4,9 DIONE; 3 (PHENYLALANYL)AMINO 3 ETHOXYCARBONYL 2,3 DIHYDROTHIENO[3,2 G]QUINOLINE 4,9 DIONE; 3 [(N PHENYLTHIOCARBAMOYL) PHENYLALANYL]AMINO 3 ETHOXYCARBONYL 2,3 DIHYDROTHIENO[2,3 G]QUINOLINE 4,9 DIONE; 3 [(N PHENYLTHIOCARBAMOYL)PHENYLALANYL]AMINO 3 ETHOXYCARBONYL 2,3 DIHYDROTHIENO[3,2 G]QUINOLINE 4,9 DIONE; 3 AMINO 3 ETHOXYCARBONYL 2,3 DIHYDROTHIENO[3,2 G]QUINOLINE 4,9 DIONE; 3 AMINO 3 ETHOXYCARBONYL 2,3 DIHYROTHIENO[2,3 G]QUINOLINE 4,9 DIONE; 6 (3',4' DICHLORO)PHENYL 8 ETHOXYCARBONYLPYRIDO[3,4 G]QUINOLINE 5,10 DIONE; 6 (4' CHLORO)PHENYL 8 ETHOXYCARBONYLPYRIDO[3,4 G]QUINOLINE 5,10 DIONE; 6 (4' METHYL)PHENYL 8 ETHOXYCARBONYLPYRIDO[3,4 G]QUINOLINE 5,10 DIONE; 6 [4' (N DIMETHYL)AMINO]PHENYL 8 ETHOXYCARBONYLPYRIDO[3,4 G]QUINOLINE 5,10 DIONE; 6 PHENYL 8 ETHOXYCARBONYLPYRIDO[3,4 G]QUINOLINE 5,10 DIONE; 9 (3',4' DICHLORO)PHENYL 7 ETHOXYCARBONYLPYRIDO[4,3 G]QUINOLINE 5,10 DIONE; 9 (4' CHLORO)PHENYL 7 ETHOXYCARBONYLPYRIDO[4,3 G]QUINOLINE 5,10 DIONE; 9 (4' METHYL)PHENYL 7 ETHOXYCARBONYLPYRIDO[4,3 G]QUINOLINE 5,10 DIONE; 9 [4' (N DIMETHYL)AMINO]PHENYL 7 ETHOXYCARBONYLPYRIDO[4,3 G]QUINOLINE 5,10 DIONE; 9 PHENYL 7 ETHOXYCARBONYLPYRIDO[4,3 G]QUINOLINE 5,10 DIONE; CYTOTOXIC AGENT; DOXORUBICIN; QUINOLINE 5,8 DIONE; QUINOLINE DERIVATIVE; THIAZOLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL LINE; COMBINATORIAL CHEMISTRY; CONTROLLED STUDY; CYCLOADDITION; CYTOTOXICITY; DRUG CONCENTRATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; PRECURSOR; T LYMPHOCYTE;

EID: 2942638151     PISSN: 14246376     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Wakelin, I.; Waring, M. J. DNA intercalating agents. In Comprehensive Medicinal Chemistry; Sammes, P.G. (Ed.), Pergamon Press: Oxford, U. K., 1990, 2, 725.
2. Verweij, J.; Schellens, J. H.; Loot, L; Pinedo, K. M. in B. A. Chabner, D. L. Longo (Eds.), Cancer Chemiotherapy and Biotherapy: Principles and Practica, J. B. Lippincott Co:, Philadelphia, 1995.
3. Krapcko, A.P.; Maresch, M. J.; Hacker, M. P.; Hazelhurst, L.; Menta, E.; Oliva, A.; Spinelli, S.; Giuliani, F.C.; Beggiolin, G.; Pezzoni, G.; Tornella, S. Curr. Med. Chem., 1995, 2, 803, and references cited therein.
4. Krapcho, A. P.; Petry, M. E.; Hacker, M. P. J. Med. Chem, 1990, 33, 2651.
5. Gandolfi, C. A.; Beggiolin, G.; Menta, E.; Palumbo, M.; Sissi, C.; Spineli, S.; Johnson, F. J. Med. Chem. 1995, 38, 526.
6. Gomez-Monterrey, I.; Campiglia, P.; Mazzoni, O.; Novellino, E.; Diurno, M. V. Tetrahedron Lett. 2001, 42, 5755.
7. Gomez-Monterrey, I.; Campiglia, P.; Grieco, P.;. Diurno, M. V ; Bolognese, A.; La Colla, P.; Novellino, E.; Biorg. Med. Chem. 2003, 11, 3769.
8. Behforouz, M.; Haddad, J.; Cai, W.; Gu, Z. J. Org. Chem. 1998, 63, 343, and references cited therein.
9. Denizot, F.; Lang, R. J. Immunol. Methods, 1986, 89, 271.
10. Pauwels, R.; Balzarini, ; Baba, M.; Snoeck, R.; Scholds, D.; Herdewijn, P.; Desmyter, J.; De Clercq, E. J. Virol. Methods, 1988, 20, 309.
11. Gilchrist, T. L.; Rochas-Gonsalves, A. M.;. Pinho e Melo, M. V. D. Tetrahedron, 1994, 50 , 13709.
12. Pratt, Y. T. ; Drake, N. L. J. Am. Chem. Soc. 1960, 82, 1155.