Neurological manifestations of cardiac myxoma: A review of the literature and report of cases

Internal Medicine Journal

Volumn 34, Issue 5, 2004, Pages 243-249

  Ekinci, E I ^a   Donnan, G A ^a,b  

^a FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Atrial myxoma; Echocardiogram; Emboli; Embolic stroke; Stroke

Indexed keywords

ADULT; AGED; ANALYTIC METHOD; AUTOPSY; CEREBROVASCULAR ACCIDENT; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DATA ANALYSIS; DEMOGRAPHY; DISEASE CLASSIFICATION; ECHOCARDIOGRAPHY; FEMALE; HEADACHE; HEALTH CENTER; HEART MYXOMA; HOSPITAL; HOSPITAL PATIENT; HUMAN; MALE; MEDICAL RECORD; MENTAL DISEASE; NEUROLOGIC DISEASE; OUTCOMES RESEARCH; PRIORITY JOURNAL; RECORDING; REVIEW; SEIZURE; SEX DIFFERENCE; STROKE; SYNCOPE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CEREBROVASCULAR ACCIDENT; CHILD; DIAGNOSIS, DIFFERENTIAL; FEMALE; HEADACHE; HEART NEOPLASMS; HUMANS; MALE; MEDICAL RECORDS; MIDDLE AGED; MYXOMA; SEIZURES; SYNCOPE;

EID: 2942627888     PISSN: 14440903     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1444-0903.2004.00563.x     Document Type: Review

References (76)

1. Barber F, Rosen P, Okin T. Atrial myxoma presenting as stroke. Ann Emerg Med 1982; 11: 316-8.
2. Bayir H, Morelli PJ, Smith TH, Biancaniello TA. A left atrial myxoma presenting as a cerebrovascular accident. Pediatr Neurol 1999; 21: 569-72.
3. McWhirter WR, Tetteh-Lartey EV. A case of atrial myxoma. Br Heart J 1974; 36: 839-40.
4. Reynen K. Cardiac myxomas. N Engl J Med 1995; 333: 1610-7.
5. Tonz M, Laske A, Carrel T, da Silva V, Real F, Turina M. Convulsions, hemiparesis and central retinal artery occlusion due to left atrial myxoma in child. Eur J Pediatr 1992; 151: 652-4.
6. Pridie RB. Left atrial myxomas in childhood: presentation with emboli - diagnosis by ultrasonics. Thorax 1972; 27: 759-63.
7. New PF, Price DL, Carter B. Cerebral angiography in cardiac myxoma. Correlation of angiographic and histopathological findings. Radiology 1970; 96: 335-45.
8. Morton-Bours EC, Jacobs MB, Albers GW. Clinical problem-solving. Eyes wide open. N Engl J Med 2000; 343: 50-5.
9. Knepper LE, Biller J, Adams HP Jr, Bruno A. Neurologic manifestations of atrial myxoma. A 12-year experience and review. Stroke 1988; 19: 1435-40.
10. Thompson WG, Rabin EZ, Sosa JA, Cronin RF. Left atrial myxoma with multiple emboli and hypercalcemia. Can Med Assoc J 1966; 95: 316-8.
11. Reynen K. Frequency of primary tumors of the heart. Am J Cardiol 1996; 77: 107.
12. Shapiro LM. Cardiac tumours: diagnosis and management. Heart 2001; 85: 218-22.
13. Tazelaar HD, Locke TJ, McGregor CG. Pathology of surgically excised primary cardiac tumors. Mayo Clin Proc 1992; 67: 957-65.
14. MacGowan SW, Sidhu P, Aherne T et al. Atrial myxoma: national incidence, diagnosis and surgical management. Ir J Med Sci 1993; 162: 223-6.
15. Pinede L, Duhaut P, Loire R. Clinical presentation of left atrial cardiac myxoma. A series of 112 consecutive cases. Medicine (Baltimore) 2001; 80: 159-72.
16. Salehian O, Demers C, Patel A. Atrial myxoma presenting as isolated unilateral blindness: a case report and review of the literature. Can J Cardiol 2001; 17: 898-900.
17. Murphy DP, Glazier DB, Krause TJ. Mitral valve myxoma. Ann Thorac Surg 1997; 64: 1169-70.
18. Carney JA, Hruska LS, Beauchamp GD, Gordon H. Dominant inheritance of the complex of myxomas, spotty pigmentation, and endocrine overactivity. Mayo Clin Proc 1986; 61: 165-72.
19. Campbell K. Early diagnosis of an atrial myxoma with central retinal artery occlusion. Ann Ophthalmol 1974; 6: 1207-11.
20. Steinmetz EF, Calanchini PR, Aguilar MJ. Left atrial myxoma as a neurological problem: a case report and review. Stroke 1973; 4: 451-8.
21. Sellke FW, Lemmer JH Jr, Vandenberg BF, Ehrenhaft JL. Surgical treatment of cardiac myxomas: long-term results. Ann Thorac Surg 1990; 50: 557-61.
22. Pucci A, Gagliardotto P, Zanini C, Pansini S, di Summa M, Mollo F. Histopathologic and clinical characterization of cardiac myxoma: review of 53 cases from a single institution. Am Heart J 2000; 140: 134-8.
23. Frank RA, Shalen PR, Harvey DG, Berg L, Ferguson TB, Schwartz HG. Atrial myxoma with intellectual decline and cerebral growths on CT scan. Ann Neurol 1979; 5: 396-400.
24. Desousa AL, Muller J, Campbell R, Batnitzky S, Rankin L. Atrial myxoma: a review of the neurological complications, metastases, and recurrences. J Neurol Neurosurg Psychiatry 1978; 41: 1119-24.
25. Gonsalves CG, Nidecker AC. Cerebral aneurysms and cardiac myxoma. J Can Assoc Radiol 1979; 30: 127-8.
26. Bulkley BH, Hutchins GM. Atrial myxomas: a fifty year review. Am Heart J 1979; 97: 639-43.
27. Sandok BA, von Estorff I, Giuliani ER. CNS embolism due to atrial myxoma: clinical features and diagnosis. Arch Neurol 1980; 37: 485-8.
28. Adams CW et al. Intracardiac myxomas and thrombi. Am J Cardiol 1961; 7: 176-87.
29. Maroon JC, Campbell RL. Atrial myxoma: a treatable cause of stroke. J Neurol Neurosurg Psychiatry 1969; 32: 129-33.
30. Surabhi SK, Fasseas P, Vandecker WA, Hanau CA, Wolf NM. Right atrial myxoma in a patient presenting with syncope. Tex Heart Inst J 2001; 28: 228-9.
31. Peterson DI. Syncope due to right atrial myxoma. Bull Clin Neurosci 1984; 49: 63-6.
32. Butler MJ, Adams HP Jr, Hiratzka LF. Recurrent cerebral embolism from a right atrial myxoma. Ann Neurol 1986; 19: 608-9.
33. Landers C, Baumann R, Cottrill CM. Embolic strokes in an 8-year-old girl. Neurology 2000; 55: 146.
34. Wolman L, Bradshaw P. Spinal cord embolism. J Neurol Neurosurg Psychiatry 1967; 30: 446-54.
35. Hirose G, Kosoegawa H, Takado M, Shimazaki K, Murakami E. Spinal cord ischemia and left atrial myxoma. Arch Neurol 1979; 36: 439.
36. Joynt RJ. Cerebral emboli from cardiac tumors. Arch Neurol 1965; 12: 184-91.
37. Silverman J, Olwin JS, Graettinger JS. Cardiac myxomas with systemic embolisation. Circulation 1962; 26: 99-103.
38. Furlong BR, Verdile VP. Myxomatous embolization resulting in unilateral amaurosis. Am J Emerg Med 1995; 13: 46-9.
39. Yarnell PR, Spann JF Jr, Dougherty J, Mason DT. Episodic central nervous system ischemia of undetermined cause: relation to occult left atrial myxoma. Stroke 1971; 2: 35-40.
40. Donnan GA, Bladin PF, Berkovic SF, Longley WA, Saling MM. The stroke syndrome of striatocapsular infarction. Brain 1991; 114: 51-70.
41. Hatano S. Experience from a multicentre stroke register: a preliminary reprt. Bull World Health Organ 1976; 54: 541-53.
42. Read RC, White HJ, Murphy ML, Williams D, Sun CN, Flanagan WH. The malignant potentiality of left atrial myxoma. J Thorac Cardiovasc Surg 1974; 68: 857-68.
43. Gee GT, Bazan C 3rd, Jinkins JR. Imaging of cerebral infarction caused by atrial myxoma. Neuroradiology 1994; 36: 271-2.
44. Bienfait HP, Moll LC. Fatal cerebral embolism in a young patient with an occult left atrial myxoma. Clin Neurol Neurosurg 2001; 103: 37-8.
45. Mukasa A, Nagata K, Kawamoto S, Sashida J. Posttraumatic cerebral infarction caused by a left atrial myxoma: case report. J Trauma 2000; 49: 1138-40.
46. Mandel MM, Strimel WH Jr. Ventricular myxoma associated with cerebral embolism. JAMA 1970; 214: 2154-6.
47. Anderson JD, Lubow M. Atrial myxoma as a source of retinal embolization. Am J Ophthalmol 1973; 76: 769-72.
48. Bolo-deoku J Jr, Orchard RT, Fison PN. Transient loss of peripheral vision as the presentation of left atrial myxoma. Br J Ophthalmol 1992; 76: 113-4.
49. Jampol LM, Wong AS, Albert DM. Atrial myxoma and central retinal artery occlusion. Am J Ophthalmol 1973; 75: 242-9.
50. Cogan DG, Wray SH. Vascular occlusions in the eye from cardiac myxomas. Am J Ophthalmol 1975; 80: 396-403.
51. Hofmann E, Becker T, Romberg-Hahnloser R, Reichmann H, Warmuth-Metz M, Nadjmi M. Cranial MRI and CT in patients with left atrial myxoma. Neuroradiology 1992; 34: 57-61.
52. Hutton JT. Atrial myxoma as a cause of progressive dementia. Arch Neurol 1981; 38: 533.
53. Roeltgen DP, Weimer GR, Patterson LF. Delayed neurologic complications of left atrial myxoma. Neurology 1981; 31: 8-13.
54. Michael AS, Mikhael MA, Christ M. Myxoma of the heart presenting with recurrent episodes of hemorrhagic cerebral infarction: MR findings. J Comput Assist Tomogr 1989; 13: 123-5.
55. Burton C, Johnston J. Multiple cerebral aneurysms and cardiac myxoma. N Engl J Med 1970; 282: 35-6.
56. Stoane L, Allen JH Jr, Collins HA. Radiologic observations in cerebral embolization from left heart myxomas. Radiology 1966; 87: 262-6.
57. Price DL, Harris JL, New PF, Cantu RC. Cardiac myxoma. A clinicopathologic and angiographic study. Arch Neurol 1970; 23: 558-67.
58. Damasio H, Seabra-Gomes R, da Silva JP, Damasio AR, Antunes JL. Multiple cerebral aneurysms and cardiac myxoma. Arch Neurol 1975; 32: 269-70.
59. Leonhardt ET, Kullenberg KP. Bilateral atrial myxomas with multiple arterial aneurysms - a syndrome mimicking polyarteritis nodosa. Am J Med 1977; 62: 792-4.
60. Attum AA, Johnson GS, Masri Z, Girardet R, Lansing AM. Malignant clinical behavior of cardiac myxomas and 'myxoid imitators'. Ann Thorac Surg 1987; 44: 217-22.
61. Olmsted WW, McGee TP. The pathogenesis of peripheral aneurysms of the central nervous system: a subject review from the AFIP. Radiology 1977; 123: 661-6.
62. Budzilovich G, Aleksic S, Greco A, Fernandez J, Harris J, Finegold M. Malignant cardiac myxoma with cerebral metastases. Surg Neurol 1979; 11: 461-9.
63. Ng HK, Poon WS. Cardiac myxoma metastasizing to the brain. Case report. J Neurosurg 1990; 72: 295-8.
64. Branch CL Jr, Laster DW, Kelly DL Jr. Left atrial myxoma with cerebral emboli. Neurosurgery 1985; 16: 675-80.
65. St John Sutton MG, Mercier LA, Giuliani ER, Lie JT. Atrial myxomas: a review of clinical experience in 40 patients. Mayo Clin Proc 1980; 55: 371-6.
66. McMullin GM, Lane R. A rare cause of acute aortic occlusion. Aust N Z J Surg 1993; 63: 65-8.
67. Schattenberg TT. Echocardiographic diagnosis of left atrial myxoma. Mayo Clin Proc 1968; 43: 620-7.
68. Thompson JR, Simmons CR. Arterial embolus. Manifestation of unsuspected myxoma. JAMA 1974; 228: 864-5.
69. Sandok BA, von Estorff I, Giuliani ER. Subsequent neurological events in patients with atrial myxoma. Ann Neurol 1980; 8: 305-7.
70. Thompson J, Kapoor W, Wechsler LR. Multiple strokes due to atrial myxoma with a negative echocardiogram. Stroke 1988; 19: 1570-1.
71. Peters MN, Hall RJ, Cooley DA, Leachman RD, Garcia E. The clinical syndrome of atrial myxoma. JAMA 1974; 230: 695-701.
72. Pindyck F, Peirce EC. 2nd, Baron MG, Lukban SB. Embolization of left atrial myxoma after transseptal cardiac cathertization. Am J Cardiol 1972; 30: 569-71.
73. Cleveland DC, Westaby S, Karp RB. Treatment of intra-atrial cardiac tumors. JAMA 1983; 249: 2799-802.
74. Burke AP, Virmani R. Cardiac myxoma. A clinicopathologic study. Am J Clin Pathol 1993; 100: 671-80.
75. Shimono T, Makino S, Kanamori Y, Kinoshita T, Yada I. Left atrial myxomas. Using gross anatomic tumor types to determine clinical features and coronary angiographie findings. Chest 1995; 107: 674-9.
76. Furlan AJ, Breuer AC. Central nervous system complications of open heart surgery. Stroke 1984; 15: 912-5.