A mutant allele of rpoD results in increased conversion of aminoimidazole ribotide to hydroxymethyl pyrimidine in Salmonella enterica

Journal of Bacteriology

Volumn 186, Issue 12, 2004, Pages 4034-4037

  Dougherty, Michael J ^a   Downs, Diana M ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; BETA GALACTOSIDASE; COCARBOXYLASE; GENE PRODUCT; PYRIMIDINE; THIAMINE;

ALLELE; ARTICLE; BIOSYNTHESIS; ESCHERICHIA COLI; GENE; MUTANT; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RPOD GENE; SALMONELLA; SALMONELLA ENTERICA; THIC GENE;

ALLELES; DNA-DIRECTED RNA POLYMERASES; GENE EXPRESSION REGULATION, BACTERIAL; MUTATION; PYRIMIDINES; RIBONUCLEOTIDES; SALMONELLA ENTERICA; SIGMA FACTOR; THIAMINE; TRANSCRIPTION, GENETIC;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA; SALMONELLA; SALMONELLA ENTERICA;

EID: 2942605813     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.186.12.4034-4037.2004     Document Type: Article

References (26)

1. Allen, S., J. L. Zilles, and D. M. Downs. 2002. Metabolic flux in both the purine mononucleotide and histidine biosynthetic pathways can influence synthesis of the hydroxymethyl pyrimidine moiety of thiamine in Salmonella enterica. J. Bacteriol. 184:6130-6137.
2. Allred, J. B., and D. G. Guy. 1969. Determination of coenzyme A and acetyl CoA in tissue extracts. Anal. Biochem. 29:293-299.
3. Begley, T. P., D. M. Downs, S. E. Ealick, F. W. McLafferty, A. P. Van Loon, S. Taylor, N. Campobasso, H. J. Chiu, C. Kinsland, J. J. Reddick, and J. Xi. 1999. Thiamine biosynthesis in prokaryotes. Arch. Microbiol. 171:293-300.
4. Brown, L., D. Gentry, T. Elliott, and M. Cashel. 2002. DksA affects ppGpp induction of RpoS at a translational level. J. Bacteriol. 184:4455-4465.
5. Caetano-Annoles, G. 1993. Amplifying DNA with arbitrary oligonucleotide primers. PCR Methods Appl. 3:85-92.
6. 70 reduce abortive transcription and enhance promoter escape. J. Biol. Chem. 278:5539-5547.
7. Castilho, B. A., P. Olfson, and M. J. Casadaban. 1984. Plasmid insertion mutagenesis and lac gene fusion with mini-Mu bacteriophage transposons. J. Bacteriol. 158:488-495.
8. Dougherty, M., and D. M. Downs. 2003. The stm4066 gene product of Salmonella enterica serovar Typhimurium has aminoimidazole riboside (AIRs) kinase activity and allows AIRs to satisfy the thiamine requirement of pur mutant strains. J. Bacteriol. 185:332-339.
9. Downs, D. M., and L. Petersen. 1994. apbA, a new genetic locus involved in thiamine biosynthesis in Salmonella typhimurium. J. Bacteriol. 176:4858-4864.
10. Enos-Berlage, J. L., and D. M. Downs. 1996. Involvement of the oxidative pentose phosphate pathway in thiamine biosynthesis in Salmonella typhimurium. J. Bacteriol. 178:1476-1479.
11. Enos-Berlage, J. L., and D. M. Downs. 1997. Mutations in sdh (succinate dehydrogenase genes) alter the thiamine requirement of Salmonella typhimurium. J. Bacteriol. 179:3989-3996.
12. Escalante-Semerena, J. C., and J. R. Roth. 1987. Regulation of cobalamin biosynthetic operons in Salmonella typhimurium. J. Bacteriol. 169:2251-2258.
13. Frodyma, M., A. Rubio, and D. M. Downs. 2000. Reduced flux through the purine biosynthetic pathway results in an increased requirement for coenzyme A in thiamine synthesis in Salmonella enterica serovar Typhimurium. J. Bacteriol. 182:236-240.
14. Gralnick, J., E. Webb, B. Beck, and D. Downs. 2000. Lesions in gshA (encoding γ-L-glutamyl-L-cysteine synthetase) prevent aerobic synthesis of thiamine in Salmonella enterica serovar Typhimurium LT2. J. Bacteriol. 182:5180-5187.
15. Hernandez, V. J., and M. Cashel. 1995. Changes in conserved region 3 of Escherichia coli sigma 70 mediate ppGpp-dependent functions in vivo. J. Mol. Biol. 252:536-549.
16. 70 is implicated in the process of abortive transcription. J. Biol. Chem. 271:18775-18779.
17. Miller, J. H. 1972. Experiments in molecular genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
18. Petersen, L., and D. M. Downs. 1996. Mutations in apbC (mrp) prevent function of the alternative pyrimidine biosynthetic pathway in Salmonella typhimurium. J. Bacteriol. 178:5676-5682.
19. Petersen, L., J. Enos-Berlage, and D. M. Downs. 1996. Genetic analysis of metabolic crosstalk and its impact on thiamine synthesis in Salmonella typhimurium. Genetics 143:37-44.
20. Primerano, D. A., and R. O. Burns. 1983. Role of acetohydroxyacid isomeroreductase in biosynthesis of pantothenic acid in Salmonella typhimurium. J. Bacteriol. 153:259-269.
21. Rubio, A., and D. M. Downs. 2002. Elevated levels of ketopantoate hydroxymethyltransferase (PanB) lead to a physiologically significant coenzyme A elevation in Salmonella enterica serovar Typhimurium. J. Bacteriol. 184:2827-2832.
22. 70 subunit of Escherichia coli RNA polymerase. J. Biol. Chem. 273:9872-9877.
23. Skovran, E., and D. M. Downs. 2000. Metabolic defects caused by mutations in the isc gene cluster in Salmonella enterica serovar Typhimurium: implications for thiamine synthesis. J. Bacteriol. 182:3896-3903.
24. Vander Horn, P. B., A. D. Backstrom, V. Stewart, and T. P. Begley. 1993. Structural genes for thiamine biosynthetic enzymes (thiCEFGH) in Escherichia coli K-12. J. Bacteriol. 175:982-992.
25. Webb, E., K. Claas, and D. Downs. 1998. thiBPQ encodes an ABC transporter required for transport of thiamine and thiamine pyrophosphate in Salmonella typhimurium. J. Biol. Chem. 273:8946-8950.
26. Zhang, Y., and T. P. Begley. 1997. Cloning, sequencing and regulation of thiA, a thiamine biosynthesis gene from Bacillus subtilis. Gene 198:73-82.