Analysis by high-performance liquid chromatography of teucrin A in beverages flavoured with an extract of Teucrium chamaedrys L

Food Additives and Contaminants

Volumn 21, Issue 5, 2004, Pages 407-414

  Bosisio, Enrica ^a   Giavarini, F ^a   Dell'Agli, M ^a   Galli, G ^a   Galli, C L ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Bitter alcoholic beverages; Germander; High performance liquid chromatography (HPLC) method; Teucrin A

Indexed keywords

DITERPENOID; GERMANDER EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ALCOHOLIC BEVERAGE; ANALYTICAL ERROR; ARTICLE; BEVERAGE; BITTER TASTE; COLUMN CHROMATOGRAPHY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CRYSTALLIZATION; DRUG PURITY; DRUG STRUCTURE; FLAVOR; FOOD ANALYSIS; FOOD CONTROL; GERMANDER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ITALY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SENSITIVITY ANALYSIS;

ALCOHOLIC BEVERAGES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DITERPENES; DRUG STABILITY; FLAVORING AGENTS; FOOD ANALYSIS; FOOD CONTAMINATION; HUMANS; REPRODUCIBILITY OF RESULTS; SPIRO COMPOUNDS; TEUCRIUM;

TEUCRIUM; TEUCRIUM CHAMAEDRYS;

EID: 2942604766     PISSN: 0265203X     EISSN: None     Source Type: Journal    
DOI: 10.1080/02652030410001670157     Document Type: Article

References (25)

1. Alcazar, R., Torre, M. C. D. L., Rodriguez, B., Bruno, M., Piozzi, F., Savona, G., and Arnold, N. A., 1992, Neoclerodane diterpenoids from three species of Teucrium. Phytochemistry, 31, 3957-3960.
2. Bruno, M., Bondi, M. L., Rosselli, S., Piozzi, F., Al-Hillo, M. R., Lamara, K., and Ladjel, S., 2000, Neoclerodane diterpenoids from Teucrium maghrebinum. Journal of Natural Products, 63, 1029-1031.
3. Bruno, M., Fazio, C., Piozzi, F., Rodriguez, B., and Torre, M. C. D. L., 1995a, Neo-clerodane diterpenoids from Teucrium corymbosum. Phytochemistry, 40, 1481-1483.
4. Bruno, M., Frazio, C., Piozzi, F., Savona, G., Rodriguez, B., and Torre, M. C. D. L., 1995b, neo-Clerodane diterpenoids from Teucrium racemosum. Phytochemistry, 40, 505-507.
5. Bruno, M., Piozzi, F., Rodriguez, B., Savona, G., Torre, M. C. D. L., and Servettaz, O., 1992, neo-Clerodane diterpenes from Teucrium species. Phytochemistry, 31, 4366-4367.
6. Castot, A., and Larrey, D., 1992, Hepatitis observed during a treatment with a drug or tea containing wild germander. Evaluation of 26 cases reported to the Regional Centers of Pharmacovigilance. Gastroenterologie Clinique et Biologique, 16, 916-922. [in French]
7. De Berardinis, V., Moulis, C., Maurice, M., Beaune, P., Pessayre, D., Pompon, D., and Loeper, J., 2000, Human microsomal epoxide hydrolase is the target of germander-induced autoantibodies on the surface of human hepatocytes. Molecular Pharmacology, 58, 542-551.
8. De Smet, P. A. G. M., 1997a, Teucrium chamaedrys. Adverse Effects of Herbal Drugs, edited by P. A. G. M. De Smet, K. Keller, R. Hansel and R. F. Chandler (Berlin: Springer), pp. 137-144.
9. De Smet, P. A. G. M., 1997b, Teucrium chamaedrys [Note]. Adverse Effects of Herbal Drugs, edited by P. A. G. M. De Smet, K. Keller, R. Hansel and R. F. Chandler (Berlin: Springer), p. 235.
10. Fau, D., Lekehal, M., Farrell, G., Moreau, A., Moulis, C., Feldmann, G., Haouzi, D., and Pessayre, D., 1997, Diterpenoids from germander, an herbal medicine, induce apoptosis in isolated rat hepatocytes [Comment]. Gastroenterology, 113, 1334-1346.
11. 13C coupling constants observed via double-quantum coherence. Journal of Organic Chemistry, 48, 5123-5126.
12. Kouzi, S. A., McMurtry, R. J., and Nelson, S. D., 1994, Hepatotoxicity of germander (Teucrium chamaedrys L.) and one of its constituent neoclerodane diterpenes teucrin A in the mouse. Chemical Research in Toxicology, 7, 850-856.
13. Lekehal, M., Pessayre, D., Lereau, J. M., Moulis, C., Fouraste, I., and Fau, D., 1996, Hepatotoxicity of the herbal medicine germander: metabolic activation of its furano diterpenoids by cytochrome P450 3A Depletes cytoskeleton-associated protein thiols and forms plasma membrane blebs in rat hepatocytes. Hepatology, 24, 212-218.
14. Loeper, J., Descatoire, V., Letteron, P., Moulis, C., Degott, C., Dansette, P., Fau, D., and Pessayre, D., 1994, Hepatotoxicity of germander in mice. Gastroenterology, 106, 464-472.
15. Malakov, P. Y., and Papanov, G. Y., 1985, Teuchamaedrin c, a neoclerodane diterpenoid from Teucrium chamaedrys. Phytochemistry, 24, 301-303.
16. Mostefa-Kara, N., Pauwels, A., Pines, E., Biour, M., and Levy, V. G., 1992, Fatal hepatitis after herbal tea. Lancet, 340, 674.
17. Perez Alvarez, J., Saez-Royuela, F., Gento Pena, E., Lopez Morante, A., Velasco Oses, A., and Martin Lorente, J., 2001, Acute hepatitis due to ingestion of Teucrium chamaedrys infusions. Gastroenterology and Hepatology, 24, 240-243.
18. Piozzi, F., 1981, The diterpenoids of Teucrium species. Heterocycles, 15, 1489-1503.
19. Piozzi, F., 1994, Further researches on the furanoclerodanes from Teucrium species. Heterocycles, 37, 603-626.
20. Piozzi, F., Bruno, M., and Rosselli, S., 1998, Further furoclerodanes from Teucrium species. Heterocycles, 48, 2185-2203.
21. Piozzi, F., Savona, G., and Rodriguez, B., 1987, Advances in the chemistry of the furanoterpenoids from Teucrium species. Heterocycles, 25, 807-841.
22. Rodriguez, M. C., Barluenga, J., Pascual, C., Rodriguez, B., Savona, G., and Piozzi, F., 1984a, Neo-clerodane diterpenoids from Teucrium chamaedrys: the identity of teucrin B with dihydroteugin. Phytochemistry, 23, 2960-2961.
23. Rodriguez, M. C., Barluenga, J., Savona, G., Piozzi, F., Servettaz, O., and Rodriguez, B., 1984b, Isoteuflidin, a neo-clerodane diterpenoid from Teucrium chamaedrys, and revised structures of teucrins F and G. Phytochemistry, 23, 1465-1469.
24. Savona, G., Garcia-Alvarez, M. C., and Rodriguez, B., 1982, Dihydroteugin, a neo-clerodane diterpenoid from Teucrium chamaedrys [aerial parts]. Phytochemistry, 21, 721-723.
25. Ulubelen, A., Topcu, G., and Kaya, U., 1994, Steroidal compounds from Teucrium chamaedrys subsp. chamaedrys. Phytochemistry, 36, 171-173.