Assessment of single-dose benzodiazepines on insulin secretion, insulin sensitivity and glucose effectiveness in healthy volunteers: A double-blind, placebo-controlled, randomized cross-over trial [ISRCTN08745124]

BMC Clinical Pharmacology

Volumn 4, Issue , 2004, Pages

  Chevassus, Hugues ^a,b   Mourand, Isabelle ^a,b   Molinier, Nathalie ^a   Lacarelle, Bruno ^c   Brun, Jean Frédéric ^d   Petit, Pierre ^a,b  

^a HÔPITAL SAINT ELOI   (France)

^b CNRS   (France)

^c TIMONE HOSPITAL   (France)

^d LAPEYRONIE HOSPITAL   (France)

Author keywords

Benzodiazepine; Clinical investigation; Diabetes; Glucose tolerance; Insulin secretion; Insulin sensitivity

Indexed keywords

BENZODIAZEPINE DERIVATIVE; CLONAZEPAM; DIAZEPAM; GLUCOSE; GLUCOSE OXIDASE; INSULIN; PLACEBO; PSYCHOTROPIC AGENT;

ADULT; AGE; ARTICLE; CAPILLARY GAS CHROMATOGRAPHY; CELL FUNCTION; CLINICAL TRIAL; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSSOVER PROCEDURE; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG EFFECT; DRUG INFUSION; ELECTRON CAPTURE DETECTION; GENDER; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; HUMAN; HUMAN EXPERIMENT; INFORMED CONSENT; INSULIN RELEASE; INSULIN RESPONSE; INSULIN SENSITIVITY; INTRAVENOUS GLUCOSE TOLERANCE TEST; MALE; MODEL; NORMAL HUMAN; PANCREAS ISLET CELL; RADIOIMMUNOASSAY; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; STATISTICAL SIGNIFICANCE; VOLUNTEER; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; INSULIN RESISTANCE; METABOLISM; METHODOLOGY; PANCREAS ISLET; PHYSIOLOGY; SECRETION (PROCESS);

ADULT; BENZODIAZEPINES; BLOOD GLUCOSE; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; INSULIN RESISTANCE; ISLETS OF LANGERHANS; MALE;

EID: 2942602783     PISSN: 14726904     EISSN: 14726904     Source Type: Journal    
DOI: 10.1186/1472-6904-4-3     Document Type: Article

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