p53 protein overexpression and p53 mutation analysis in patients with intestinal metaplasia of the cardia and Barrett's esophagus

Cancer Letters

Volumn 210, Issue 2, 2004, Pages 213-218

  Segal, Fábio ^a   Kaspary, Ana Paula Bohn ^a   Prolla, João Carlos ^a   Leistner, Sandra ^a  

^a HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

Author keywords

Barrett's esophagus; BE, Barrett's esophagus; IMC, Intestinal metaplasia of cardia; Immunohistochemistry; Intestinal metaplasia; LOH, Loss of heterozygosity; Loss of heterozygosity; Molecular biology; p53; PCR, Polymerase chain reaction

Indexed keywords

PROTEIN P53;

ADULT; AGED; ANALYTIC METHOD; ARTICLE; BARRETT ESOPHAGUS; CARDIA; CONTROLLED STUDY; EXON; FEMALE; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTESTINE METAPLASIA; MAJOR CLINICAL STUDY; MALE; MUTATIONAL ANALYSIS; P53 GENE; PATIENT; PREVALENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR SUPPRESSOR GENE;

ADULT; AGED; AGED, 80 AND OVER; BARRETT ESOPHAGUS; CARDIA; DNA MUTATIONAL ANALYSIS; ESOPHAGITIS; FEMALE; GENE EXPRESSION PROFILING; GENES, P53; GENOMIC INSTABILITY; HUMANS; IMMUNOHISTOCHEMISTRY; LOSS OF HETEROZYGOSITY; MALE; METAPLASIA; MIDDLE AGED; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 2942597744     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2004.01.020     Document Type: Article

References (25)

1. Shaheen N.J., Crosby M.A., Bozimsky E.M., Sandler R.S. Is there publication bias in the reporting of cancer risk in Barrett's esophagus? Gastroenterology. 119:2000;333-338
2. Cameron A.J., Zinsmeister A.R., Ballard D.J., Carney J.A. Prevalence of columnar-lined (Barrett's) esophagus. Comparison of population-based clinical and autopsy findings. Gastroenterology. 99:1990;918-922
3. Barrett M.T., Galipeau P.C., Sanchez C.A., Emond M.J., Reid B.J. Determination of the frequency of loss of heterozygosity in esophageal adenocarcinoma by cell sorting, whole genome amplification and microsatellite polymorphisms. Oncogene. 12:1996;1873-1878
4. Aldulaimi D., Jankowski J. Barrett's esophagus: an overview of the molecular biology. Dis. Esophagus. 12:1999;177-180
5. Lagergren J., Bergstrom R., Lindgren A., Nyren O. Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N. Engl. J. Med. 340:1999;825-831
6. Glickman J.N., Chen Y.Y., Wang H.H., Antonioli D.A., Odze R.D. Phenotypic characteristics of a distinctive multilayered epithelium suggests that it is a precursor in the development of Barrett's esophagus. Am. J. Surg. Pathol. 25:2001;569-578
7. Ireland A.P., Shibata D.K., Chandrasoma P., Lord R.V., Peters J.H., DeMeester T.R. Clinical significance of p53 mutations in adenocarcinoma of the esophagus and cardia. Ann. Surg. 231:2000;179-187
8. Gleeson C.M., Sloan J.M., McGuigan J.A., Ritchie A.J., Russell S.E. Base transitions at CpG dinucleotides in the p53 gene are common in esophageal adenocarcinoma. Cancer Res. 55:1995;3406-3411
9. Ireland A.P., Clark G.W., DeMeester T.R. Barrett's esophagus. The significance of p53 in clinical practice. Ann. Surg. 225:1997;17-30
10. Levine A.J., Momand J., Finlay C.A. The p53 tumour suppressor gene. Nature. 351:1991;453-456
11. Flejou J.F., Paraf F., Potet F., Muzeau F., Fekete F., Henin D. p53 protein expression in Barrett's adenocarcinoma: a frequent event with no prognostic significance. Histopathology. 24:1994;487-489
12. Rice T.W., Goldblum J.R., Falk G.W., Tubbs R.R., Kirby T.J., Casey G. p53 immunoreactivity in Barrett's metaplasia, dysplasia, and carcinoma. J. Thorac. Cardiovasc. Surg. 108:1994;1132-1137
13. Sjogren S., Inganas M., Norberg T., Lindgren A., Nordgren H., Holmberg L., Bergh J. The p53 gene in breast cancer: prognostic value of complementary DNA sequencing versus immunohistochemistry. J. Natl. Cancer Inst. 88:1996;173-182
14. Casson A.G., Mukhopadhyay T., Cleary K.R., Ro J.Y., Levin B., Roth J.A. p53 gene mutations in Barrett's epithelium and esophageal cancer. Cancer Res. 51:1991;4495-4499
15. Younes M., Lebovitz R.M., Lechago L.V., Lechago J. p53 protein accumulation in Barrett's metaplasia, dysplasia, and carcinoma: a follow-up study. Gastroenterology. 105:1993;1637-1642
16. Hardwick R.H., Shepherd N.A., Moorghen M., Newcomb P.V., Alderson D. Adenocarcinoma arising in Barrett's oesophagus: evidence for the participation of p53 dysfunction in the dysplasia/carcinoma sequence. Gut. 35:1994;764-768
17. Ireland A.P., Shibata D.K., Chandrasoma P., Lord R.V., Peters J.H., DeMeester T.R. Clinical significance of p53 mutations in adenocarcinoma of the esophagus and cardia. Ann. Surg. 231:2000;179-187
18. Oberg S., Peters J.H., DeMeester T.R., Chandrasoma P., Hagen J.A., Ireland A.P., et al. Inflammation and specialized intestinal metaplasia of cardiac mucosa is a manifestation of gastroesophageal reflux disease. Ann. Surg. 1997;522-532
19. Armstrong D., Blum A.L., Savary M. Reflux disease and Barrett's oesophagus. Endoscopy. 24:1992;9-17
20. Miller S.A., Dykes D.D., Polesky H.F. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 16:1988;1215
21. Orita M., Iwahana H., Kanazawa H., Hayashi K., Sekiya T. Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms. Proc. Natl. Acad. Sci. USA. 86:1989;2766-2770
22. Cameron A.J. Barrett's esophagus and adenocarcinoma: from the family to the gene. Gastroenterology. 102:1992;1421-1424
23. Finlay C.A., Hinds P.W., Tan T.H., Eliyahu D., Oren M., Levine A.J. Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life. Mol. Cell. Biol. 8:1988;531-539
24. Barnes D.M., Hanby A.M., Gillett C.E., Mohammed S., Hodgson S., Bobrow L.G., et al. Abnormal expression of wild type p53 protein in normal cells of a cancer family patient. Lancet. 340:1992;259-263
25. TP53 mutation database, in: (IARC: International Agency for Research Cancer, 2002).