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Volumn 37, Issue 7, 2004, Pages 1307-1318

Liquid chromatography-mass spectrometric analysis of compound K, a ginseng saponin metabolite, in rat plasma

Author keywords

Compound K; Ginseng saponin metabolite; LC MS; Plasma

Indexed keywords

ACETONITRILE; AMMONIUM FORMATE; GINSENG SAPONIN; LITHOSPERMIC ACID; LITHOSPERMIC ACID B; UNCLASSIFIED DRUG;

EID: 2942594000     PISSN: 00032719     EISSN: None     Source Type: Journal    
DOI: 10.1081/AL-120035900     Document Type: Article
Times cited : (6)

References (20)
  • 2
    • 0030757369 scopus 로고    scopus 로고
    • Panax ginseng pharmacology: A nitric oxide link?
    • Gillis, C.N. Panax ginseng pharmacology: a nitric oxide link? Biochem. Pharmacol. 1997, 54, 1-8.
    • (1997) Biochem. Pharmacol. , vol.54 , pp. 1-8
    • Gillis, C.N.1
  • 3
    • 0035653529 scopus 로고    scopus 로고
    • Chemistry and cancer preventing activities of Ginseng saponins and some related triterpenoid compounds
    • Shibata, S. Chemistry and cancer preventing activities of Ginseng saponins and some related triterpenoid compounds. J. Korean Med. Sci. 2001, 16, S28-S37.
    • (2001) J. Korean Med. Sci. , vol.16
    • Shibata, S.1
  • 5
    • 0029840531 scopus 로고    scopus 로고
    • Main Ginseng saponin metabolites formed by intestinal bacteria
    • Hasegawa, H.; Sung, J.H.; Matsumiya, S.; Uchiyama, M. Main Ginseng saponin metabolites formed by intestinal bacteria. Planta Med. 1996, 62, 453-457.
    • (1996) Planta Med. , vol.62 , pp. 453-457
    • Hasegawa, H.1    Sung, J.H.2    Matsumiya, S.3    Uchiyama, M.4
  • 6
    • 0030864673 scopus 로고    scopus 로고
    • Role of human intestinal Prevotella oris in hydrolyzing Ginseng saponins
    • Hasegawa, H.; Sung, J.H.; Benno, Y. Role of human intestinal Prevotella oris in hydrolyzing Ginseng saponins. Planta Med. 1997, 63, 436-440.
    • (1997) Planta Med. , vol.63 , pp. 436-440
    • Hasegawa, H.1    Sung, J.H.2    Benno, Y.3
  • 8
    • 85009708837 scopus 로고    scopus 로고
    • 1 by intestinal bacteria, in rat plasma after oral administration: Measurement of compound K by enzyme immunoassay
    • 1 by intestinal bacteria, in rat plasma after oral administration: measurement of compound K by enzyme immunoassay. Biol. Pharm. Bull. 1998, 21, 245-249.
    • (1998) Biol. Pharm. Bull. , vol.21 , pp. 245-249
    • Akao, T.1    Kanaoka, M.2    Kobashi, K.3
  • 9
    • 0034113843 scopus 로고    scopus 로고
    • Pharmacokinetics of ginsenoside deglycosylated by intestinal bacteria and its transformation to biologically active fatty acid esters
    • Hasegawa, H.; Lee, K.S.; Nagaoka, T.; Tezuka, Y.; Uchiyama, M.; Kadota, S.; Saiki, I. Pharmacokinetics of ginsenoside deglycosylated by intestinal bacteria and its transformation to biologically active fatty acid esters. Biol. Pharm. Bull. 2000, 23, 298-304.
    • (2000) Biol. Pharm. Bull. , vol.23 , pp. 298-304
    • Hasegawa, H.1    Lee, K.S.2    Nagaoka, T.3    Tezuka, Y.4    Uchiyama, M.5    Kadota, S.6    Saiki, I.7
  • 13
    • 0032577217 scopus 로고    scopus 로고
    • An intestinal bacterial metabolite of ginseng protopanaxadiol saponins has the ability to induce apoptosis in tumor cells
    • Wakabayashi, C.; Murakami, K.; Hasegawa, H.; Murata, J.; Saiki, I. An intestinal bacterial metabolite of ginseng protopanaxadiol saponins has the ability to induce apoptosis in tumor cells. Biochem. Biophys. Res. Commun. 1998, 246, 725-730.
    • (1998) Biochem. Biophys. Res. Commun. , vol.246 , pp. 725-730
    • Wakabayashi, C.1    Murakami, K.2    Hasegawa, H.3    Murata, J.4    Saiki, I.5
  • 14
    • 0028853696 scopus 로고
    • Reversal of daunomycin and vinblastine resistance in multidrug-resistant P388 leukemia in vitro through enhanced cytotoxicity by triterpenoids
    • Hasegawa, H.; Sung, J.H.; Matsumiya, S.; Uchiyama, M.; Inouye, Y.; Kasai, R.; Yamasaki, K. Reversal of daunomycin and vinblastine resistance in multidrug-resistant P388 leukemia in vitro through enhanced cytotoxicity by triterpenoids. Planta Med. 1995, 61, 409-413.
    • (1995) Planta Med. , vol.61 , pp. 409-413
    • Hasegawa, H.1    Sung, J.H.2    Matsumiya, S.3    Uchiyama, M.4    Inouye, Y.5    Kasai, R.6    Yamasaki, K.7
  • 15
    • 0032421318 scopus 로고    scopus 로고
    • 1 in dependence on intestinal bacterial hydrolyzing potential and significance of treatment with an active bacterial metabolite
    • 1 in dependence on intestinal bacterial hydrolyzing potential and significance of treatment with an active bacterial metabolite. Planta Med. 1998, 64, 696-700.
    • (1998) Planta Med. , vol.64 , pp. 696-700
    • Hasegawa, H.1    Uchiyama, M.2
  • 16
    • 0032782069 scopus 로고    scopus 로고
    • Antitumor activity of a novel ginseng saponin metabolite in human pulmonary adenocarcinoma cells resistant to cisplatin
    • Lee, S.J.; Sung, J.H.; Lee, S.J.; Moon, C.H.; Lee, B.H. Antitumor activity of a novel ginseng saponin metabolite in human pulmonary adenocarcinoma cells resistant to cisplatin. Cancer Lett. 1999, 144, 39-43.
    • (1999) Cancer Lett. , vol.144 , pp. 39-43
    • Lee, S.J.1    Sung, J.H.2    Lee, S.J.3    Moon, C.H.4    Lee, B.H.5
  • 17
    • 0034284840 scopus 로고    scopus 로고
    • Induction of apoptosis by a novel intestinal metabolite of ginseng saponin via cytochrome c-mediated activation of caspase-3 protease
    • Lee, S.J.; Go, W.G.; Kim, J.H.; Sung, J.H.; Lee, S.J.; Moon, C.H.; Lee, B.H. Induction of apoptosis by a novel intestinal metabolite of ginseng saponin via cytochrome c-mediated activation of caspase-3 protease. Biochem. Pharmacol. 2000, 60, 677-685.
    • (2000) Biochem. Pharmacol. , vol.60 , pp. 677-685
    • Lee, S.J.1    Go, W.G.2    Kim, J.H.3    Sung, J.H.4    Lee, S.J.5    Moon, C.H.6    Lee, B.H.7
  • 18
    • 0036558455 scopus 로고    scopus 로고
    • Ginseng intestinal metabolite-I (GIM-I) reduces doxorubicin toxicity in the mouse testis
    • Kang, J.K.; Lee, Y.J.; No, K.O.; Jung, E.Y.; Sung, J.H.; Kim, Y.B.; Nam, S.Y. Ginseng intestinal metabolite-I (GIM-I) reduces doxorubicin toxicity in the mouse testis. Reprod. Toxicol. 2002, 16, 291-298.
    • (2002) Reprod. Toxicol. , vol.16 , pp. 291-298
    • Kang, J.K.1    Lee, Y.J.2    No, K.O.3    Jung, E.Y.4    Sung, J.H.5    Kim, Y.B.6    Nam, S.Y.7
  • 19
    • 0038163804 scopus 로고    scopus 로고
    • Antiallergic activity of ginseng and its ginsenosides
    • Choo, M.K.; Park, E.K.; Han, M.J.; Kim, D.H. Antiallergic activity of ginseng and its ginsenosides. Planta Med. 2003, 69, 518-522.
    • (2003) Planta Med. , vol.69 , pp. 518-522
    • Choo, M.K.1    Park, E.K.2    Han, M.J.3    Kim, D.H.4
  • 20
    • 1542707445 scopus 로고    scopus 로고
    • Inhibition of intracerebroventricular injection stress-induced plasma corticosterone levels by intracerebroventricularly administered compound K, a ginseng saponin metabolite, in mice
    • Kim, D.H.; Jung, J.S.; Moon, Y.S.; Sung, J.H.; Suh, H.W.; Kim, Y.H.; Song, D.K. Inhibition of intracerebroventricular injection stress-induced plasma corticosterone levels by intracerebroventricularly administered compound K, a ginseng saponin metabolite, in mice. Biol. Pharm. Bull. 2003, 26, 1035-1038.
    • (2003) Biol. Pharm. Bull. , vol.26 , pp. 1035-1038
    • Kim, D.H.1    Jung, J.S.2    Moon, Y.S.3    Sung, J.H.4    Suh, H.W.5    Kim, Y.H.6    Song, D.K.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.