Recombinant antigen from Helicobacter pylori urease as vaccine against H. pylori-associated disease

Biotechnology and Bioengineering

Volumn 86, Issue 7, 2004, Pages 737-746

  Fujii, Ryoji ^a   Morihara, Fumiko ^a   Fukushima, Keigo ^b   Oku, Takashi ^b   Hifumi, Emi ^b,c   Uda, Taizo ^b,c  

^a Fukuyama Medical Laboratory Co   (Japan)

^b PREFECTURAL UNIVERSITY OF HIROSHIMA   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Enzymatic activity; Helicobacter pylori; Inhibitory effect; Monoclonal antibody; Urease

Indexed keywords

AMINO ACIDS; ENZYMES; ESCHERICHIA COLI; IMMUNOLOGY; MONOCLONAL ANTIBODIES; VACCINES;

HOMOLOGY-BASED STUDIES; PATHOGENS;

BIOTECHNOLOGY;

ANTISERUM; FREUND ADJUVANT; HELICOBACTER PYLORI VACCINE; HYBRID PROTEIN; MONOCLONAL ANTIBODY; RECOMBINANT ANTIGEN; UREASE;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; BETA CHAIN; CONTROLLED STUDY; CROSS REACTION; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME STRUCTURE; ESCHERICHIA COLI; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; HUMAN TISSUE; IMMUNIZATION; NONHUMAN; RABBIT; SEQUENCE HOMOLOGY; STOMACH MUCOSA;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, BACTERIAL; ANTIBODIES, MONOCLONAL; ANTIGENS, BACTERIAL; BACTERIAL VACCINES; BINDING SITES; GASTRIC MUCOSA; GASTROINTESTINAL DISEASES; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; HYBRIDOMAS; MICE; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN SUBUNITS; RABBITS; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; UREASE;

BACTERIA (MICROORGANISMS); CANAVALIA ENSIFORMIS; ESCHERICHIA COLI; HELICOBACTER; HELICOBACTER PYLORI; ORYCTOLAGUS CUNICULUS; PHASEOLUS (ANGIOSPERM);

EID: 2942590493     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.20047     Document Type: Article

References (19)

1. Andrews AT, Reithel FJ. 1970. The thiol groups of Jack bean urease. Arch Biochem Biophys 141:538-546.
2. Barer MR, Elliott TSJ, Berkeley D, Thomas JE, Eastham EJ. 1986. Cytopathic effects of Campylobacter pylori urease. J Clin Pathol 41:597.
3. Buck GE. 1990. Campylobacter pylori and gastroduodenal disease. Clin Microbiol Rev 3:1-12.
4. Corthesy-Theulaz I, Porta N, Glauser M, Saraga E, Vaney A-C, Haas R, Kraehenbuhl J-P, Blum AL, Michetti P. 1995. Oral immunization with Helicobacter pylori urease B subunit as a treatment against Helicobacter infection in mice. Gastroenterology 109:115-121.
5. Czinn SJ, Nedrud JG. 1991. Oral immunization against Helicobacter pylori. Infect Immun 59:2359-2363.
6. Dixon NE, Gazzola C, Blakeley RL, Zerner B. 1975. Jack bean urease. A metalloenzyme. A simple biological role for nickel? J Am Chem Soc 97:4131-4133.
7. Dixon NE, Blakeley RL, Zerner B. 1980. Jack bean urease. I. A simple dry ashing procedure for the microdetermination of trace metals in proteins. The nickel content of urease. Can J Biochem 58:469-473.
8. Goodwin CS, Blake P, Blincow E. 1986. The minimum inhibitory and bactericidal concentrations of antibiotics and anti-ulcer agents against Campylobacter pyloridis. J Microb Chemother 17:309-314.
9. Graham DY, Malaty HM, Evans DG, Evans DJ Jr, Klein PD, Adam E. 1991. Epidemiology of Helicobacter pylori in an asymptomatic population in the United States. Effect of age, race, and socioeconomic status. Gastroenterology 100:1495-1501.
10. Ha NC, Oh ST, Sung JY, Cha KA, Lee MH, Oh BH. 2001. Supramolecular assembly and acid resistance of Helicobacter pylori urease. Nat Struct Biol 8:505-509.
11. Hazell S, Lee A. 1986. Campylobacter pyloridis, urease, hydrogen ion back diffusion, and gastric ulcers. Lancet ii:15-17.
12. Hu LT, Mobley HL. 1990. Purification and N-terminal analysis of urease from Helicobacter pylori. Infect Immun 58:992-998.
13. Ikeda Y, Fujii R, Ogino K, Fukushima K, Hifumi E, Uda T. 1998. Immunological features and inhibitory effects on enzymatic activity of monoclonal antibodies against Helicobacter pylori urease. J Ferment Bioeng 86:271-276.
14. Nagata K, Satoh H, Iwahi T, Shimoyama T, Tamura T. 1993. Potent inhibitory action of the gastric proton pump inhibitor lansoprazole against urease activity of Helicobacter pylori: unique action selective for H. pylori cells. Antimicrob Agents Chemother 37:769-774.
15. Pallen MJ, Clayton CL. 1990. Vaccination against Helicobacter pylori urease. Lancet 336:186-187.
16. Smoot DT, Mobley HLT, Chippendale GR, Lawison JF, Resau JH. 1990. Helicobacter pylori urease activity is toxic to human gastric epithelial cell. Infect Immun 58:1992-1994.
17. Sugino N, Shimamura K, Takiguchi S, Tamura H, Ohno M, Nakata M, Ogino K, Uda T, Kato H. 1996. Changes in activity of superoxide dismutase in the human endometrium throughout the menstrual cycle and in early pregnancy. Hum Reprod 11:1073-1078.
18. Suzuki T, Sugino N, Fukaya T, Sugiyama S, Uda T, Takaya R, Yajima A, Sasano H. 1999. Super oxide dismutase in normal cycling human ovaries: immunohistochemical localization and characterization. Fertil Steril 72:720-726.
19. Takishima K, Suga T, Mamiya G. 1988. The structure of jack bean urease. Eur J Biochem 175:151-165.