Pharmacokinetics of voriconazole and cytochrome p450 2C19 genetic status [2]

Clinical Pharmacology and Therapeutics

Volumn 75, Issue 6, 2004, Pages 587-588

  Ikeda, Yasuhiko ^a   Umemura, Kazuo ^a   Kondo, Kazunao ^a   Sekiguchi, Kaneo ^b   Miyoshi, So ^b   Nakashima, Mitsuyoshi ^c  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b PFIZER INC   (United States)

^c Hamamatsu Institute of Clinical Pharmacology and Therapeutics   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN; CYTOCHROME P450 2C19; GLUCURONIDE; VORICONAZOLE;

AREA UNDER THE CURVE; CLINICAL PROTOCOL; COMPARATIVE STUDY; DOSE TIME EFFECT RELATION; DRUG BLOOD LEVEL; DRUG COMPETITION; DRUG EXCRETION; DRUG METABOLISM; GENETIC ANALYSIS; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; LETTER; LIVER FUNCTION TEST; MEDICAL ASSESSMENT; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ARYL HYDROCARBON HYDROXYLASES; HUMANS; MIXED FUNCTION OXYGENASES; PYRIMIDINES; TRIAZOLES;

EID: 2942588775     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clpt.2004.02.002     Document Type: Letter

References (5)

1. Romero A.J., Pogamp P.L., Nilsson L.G., Wood N. Effect of voriconazole on the pharmacokinetics of cyclosporine in renal transplant patients. Clin Pharmacol Ther. 71:2002;226-234
2. Hyland R., Jones B.C., Smith D.A. Identification of the cytochrome P450 enzymes involved in the N-oxidation of voriconazole. Drug Metab Dispos. 31:2003;540-547
3. Nakamura K., Goto F., Ray W.A., McAllister C.B., Jacqz E., Wilkinson G.R., et al. Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations. Clin Pharmacol Ther. 38:1985;402-408
4. Horai Y., Nakano M., Ishizaki T., Ishikawa K., Zhou H.H., Zhou B.I., et al. Metoprolol and mephenytoin oxidation polymorphisms in Far Eastern Oriental subjects Japanese versus mainland Chinese. Clin Pharmacol Ther. 46:1989;198-207
5. Kubota T., Chiba K., Ishizaki T. Genotyping of S-mephenytoin 4′-hydroxylation in an extended Japanese population. Clin Pharmacol Ther. 60:1996;661-666