Etoricoxib in acute pain associated with dental surgery: A randomized, double-blind, placebo- and active comparator-controlled dose-ranging study

Clinical Therapeutics

Volumn 26, Issue 5, 2004, Pages 667-679

  Malmstrom, Kerstin ^a   Sapre, Aditi ^a   Coughlin, Heather ^a   Agrawal, Nancy G B ^a   Mazenko, Ralph S ^a   Fricke Jr , James R ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Pharmaceutical Product Development   (United States)

Author keywords

Acute dental pain; Analgesia; Cyclooxygenase 2 selective inhibitor; Etoricoxib; Ibuprofen; Postsurgery

Indexed keywords

ANALGESIC AGENT; ETORICOXIB; IBUPROFEN;

ADULT; ANALGESIA; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DENTAL SURGERY; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG EFFICACY; DRUG TOLERABILITY; FEMALE; HEADACHE; HUMAN; LUNG ALVEOLITIS; MAJOR CLINICAL STUDY; MALE; NAUSEA; PAIN; PAIN ASSESSMENT; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SINGLE DRUG DOSE; TOOTH DISEASE; TOOTH EXTRACTION;

EID: 2942580897     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/S0149-2918(04)90067-7     Document Type: Article

References (23)

1. Vane JR, Botting RM. Biological properties of cyclooxygenase products. In: Cunningham FM, ed. Lipid Mediators. New York: Academic Press Ltd; 1994:61-97.
2. Abramson SB, Weissman G. The mechanisms of action of nonsteroidal antiinflammatory drugs. Arthritis Rheum. 1989;32:1-9.
3. Willoughby D, Lawrence T, Colville-Nash P. Cyclooxygenase-2 in experimental models of inflammation. In: Vane JR, Botting RM, eds. Therapeutic Roles of Selective COX-2 Inhibitors. London: William Harvey Press; 2001:95-127.
4. Morrison BW, Christensen S, Yuan W, et al. Analgesic efficacy of the cyclooxygenase-2-specific inhibitor rofecoxib in post-dental surgery pain: A randomized, controlled trial. Clin Ther. 1999;21:943-953.
5. Chang DJ, Desjardins PJ, Chen E, et al. Comparison of the analgesic efficacy of rofecoxib and enteric-coated diclofenac sodium in the treatment of postoperative dental pain: A randomized, placebo-controlled clinical trial. Clin Ther. 2002;24:490-503.
6. Clemett D, Goa KL. Celecoxib: A review of its use in osteoarthritis, rheumatoid arthritis and acute pain [published correction appears in Drugs. 2001;61:498]. Drugs. 2000;59:957-980.
7. Tramer MR, Williams JE, Carroll D, et al. Comparing analgesic efficacy of non-steroidal anti-inflammatory drugs given by different routes in acute and chronic pain: A qualitative systematic review. Acta Anaesthesiol Scand. 1998;42:71-79.
8. Laine L. The gastrointestinal effects of nonselective NSAIDs and COX-2-selective inhibitors. Semin Arthritis Rheum. 2002;32(Suppl 1):25-32.
9. Malmstrom K, Kotey P, Coughlin H, et al. Efficacy of etoricoxib, naproxen sodium, and acetaminophen/ codeine in acute dental pain. Clin Pharmacol Ther. 2001;69:P2. Abstract P1-6.
10. Malmstrom K, Kotey P, Cichanowitz N, et al. Analgesic efficacy of etoricoxib in primary dysmenorrhea: Results of a randomized, controlled trial. Gynecol Obstet Invest. 2003;56:65-69.
11. Forbes JA. Oral surgery. In: Max MB, Portenoy R, Laska EM, eds. The Design of Analgesic Clinical Trials. Advances in Pain Research and Therapy. New York: Raven Press; 1991:347-374.
12. Cooper SA. Five studies on ibuprofen for postsurgical dental pain. Am J Med. 1984;77:70-77.
13. Desjardins P, Black P, Papageorge M, et al. Ibuprofen arginate provides effective relief from postoperative dental pain with a more rapid onset of action than ibuprofen. Eur J Clin Pharmacol. 2002;58:387-394.
14. Black P, Max MB, Desjardins PJ, et al. A randomized, double-blind, placebo-controlled comparison of the analgesic efficacy, onset of action, and tolerability of ibuprofen arginate and ibuprofen in postoperative dental pain. Clin Ther. 2002;24:1072-1089.
15. Matthews CZ, Woolf EJ, Lin L, et al. High-throughput, semi-automated determination of a cyclooxygenase II inhibitor in human plasma and urine using solid-phase extraction in the 96-well format and high-performance liquid chromatography with post-column photochemical derivatization-fluorescence detection. J Chromatogr B. 2001;751:237-246.
16. Chow SC, Liu JP. Design and Analysis of Clinical Trials: Concepts and Methodologies. 2nd ed. New York: John Wiley & Sons; 2003.
17. Norholt SE. Treatment of acute pain following removal of mandibular third molars. Use of the dental pain model in pharmacological research and development of a comparable animal model. Int J Oral Maxillofac Surg. 1998;27(Suppl 1):1-41.
18. Agrawal NG, Porras AG, Matthews CZ, et al. Single-and multiple-dose pharmacokinetics of etoricoxib, a selective inhibitor of cyclooxygenase-2, in man. J Clin Pharmacol. 2003;43:268-276.
19. Rodrigues AD, Halpin RA, Geer LA, et al. Absorption, metabolism, and excretion of etoricoxib, a potent and selective cyclooxygenase-2 inhibitor, in healthy male volunteers. Drug Metab Dispos. 2003;31:224-232.
20. Beaver WT. Review of the analgesic efficacy of ibuprofen. Int J Clin Pract Suppl. 2003;135:13-17.
21. Leung AT, Malmstrom K, Gallacher AE, et al. Efficacy and tolerability profile of etoricoxib in patients with osteoarthritis: A randomized, double-blind, placebo and active-comparator controlled 12-week efficacy trial. Curr Med Res Opin. 2002;18:49-58.
22. Matsumoto AK, Melian A, Mandel DR, et al. A randomized, controlled, clinical trial of etoricoxib in the treatment of rheumatoid arthritis. J Rheumatol 2002;29:1623-1630.
23. Collantes E, Curtis SP, Lee KW et al, for the Etoricoxib Rheumatoid Arthritis Study Group. A multinational randomized, controlled, clinical trial of etoricoxib in the treatment of rheumatoid arthritis. BMC Fam Pract. 2002;3:1-29.