Can mutation and selection explain virulence in human P. falciparum infections?

Malaria Journal

Volumn 3, Issue , 2004, Pages 1-5

  Hastings, Ian M ^a   Paget McNicol, S ^b   Saul, A ^c  

^a LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^b ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HOST PARASITE INTERACTION; MALARIA; MALARIA FALCIPARUM; MUTATION; PARASITE PREVALENCE; PARASITE TRANSMISSION; PARASITE VIRULENCE; PLASMODIUM FALCIPARUM; POPULATION SIZE; REVIEW; WILD TYPE; ANIMAL; ARTICLE; DRUG RESISTANCE; DRUG SENSITIVITY; GENE; GENE FREQUENCY; GENETIC SELECTION; GENETICS; HUMAN; MOLECULAR EVOLUTION; PARASITOLOGY; PATHOGENICITY; VIRULENCE;

ANIMALS; DRUG RESISTANCE; EVOLUTION, MOLECULAR; GENE FREQUENCY; GENES, PROTOZOAN; HUMANS; MALARIA, FALCIPARUM; MUTATION; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; SELECTION, GENETIC; VIRULENCE;

EID: 2942575897     PISSN: 14752875     EISSN: None     Source Type: Journal    
DOI: 10.1186/1475-2875-3-1     Document Type: Review

References (20)

1. Ebert D: The evolution and expression of parasite virulence. In Evolution in Health and Disease Edited by: Stearns SC. Oxford: Oxford University Press; 1999:161-172.
2. Weiss RA: Virulence and pathogenesis. Trends Microbiol 2002, 10:314-317.
3. Burch CL, Chao L: Evolution by small steps and rugged landscapes in the RNA virus theta6. Genetics 1999, 151:921-927.
4. Miralles R, Moya A, Elena SF: Diminishing returns of population size in the rate of RNA virus adaptation. J Virol 2000, 74:3566-3571.
5. Hartl DL: The physiology of weak selection. Genome 1989, 31:183-189.
6. Lenski RE: Experimental studies of pleiotropy and epistasis in Escherichia coli. II. Compensation for maladaptive effects associated with resistance to virus T4. Evolution 1988, 42:433-440.
7. Levin BR, Perrot V, Walker N: Compensatory mutations, antibiotic resistance and the population genetics of adaptive evolution in bacteria. Genetics 2000, 154:985-997.
8. Moore FBG, Rozen DE, Lenski RE: Pervasive compensatory adaptation in Escherichia coli. Proc R Soc Lond B Biol Sci 2000, 267:515-522.
9. Schrag SJ, Perrot V, Levin BR: Adaptation to the fitness costs of antibiotic resistance in Escherichia coli. Proc R Soc Lond B Biol Sci 1997, 264:1287-1291.
10. Looareesuwan S, Viravan C, Webster HK, Kyle DE, Canfield CJ: Clinical studies of atovaquone, alone or in combination with other antimalarial drugs, for treatment of acute uncomplicated malaria in Thailand. Am J Trop Med Hyg 1996, 54:62-66.
11. Baruch DI, Pasloske BL, Singh HB, Bi XH, Ma XC, Feldman M, Taraschi TF, Howard RJ: Cloning the Plasmodium falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes. Cell 1995, 82:77-87.
12. Su XZ, Heatwole VM, Wertheimer SP, Guinet F, Herrfeldt JA, Peterson DS, Ravetch JA, Wellems TE: The large diverse gene family Var encodes proteins involved in cytoadherence and antigenic varaiation of Plasmodium-falciparum-infected erythrocytes. Cell 1995, 82:89-100.
13. Falconer DS, Mackay TFC: Introduction to Quantitative Genetics 4th edition. Harlow: Longman; 1996.
14. Hartl DL, Clark AG: Principles of Population Genetics 3rd edition. Sunderland, Ma, USA: Sinauer Associates; 1997.
15. Brannan LR, Turner CMR, Phillips RS: Malaria parasites undergo antigenic variation at high ratesin vivo. Proc R Soc Lond B Biol Sci 1994, 256:71-75.
16. Molineaux L, Diebner HH, Eichner M, Collins WE, Jeffery GM, Dietz K: Plasmodium falciparum parasitaemia described by a new mathematical model. Parasitology 2001, 122:379-391.
17. Paget-McNicol S, Gatton M, Hastings IM, Saul A: The Plasmodium falciparum var gene switching rate, switching mechanism and patterns of parasite recrudescence described by mathematical modelling. Parasitology 2002, 124:225-235.
18. Gatton ML, Hogarth W, Saul A: Time of treatment influences the appearance of drug-resistant parasites in Plasmodium falciparum infections. Parasitology 2001, 123:537-546.
19. Carter R, Graves PM: Gametocytes. In Malaria: principles and practice of malariology Edited by: Wernsdorfer WH, McGregor I.Edinburgh: Churchill Livingston; 1988:253-305.
20. Taylor LH, Read AF: Why so few transmission stages? Reproductive restraint by malaria parasites. Parasitol Today 1997, 13:135-140.