Radioprotective effect of podophyllotoxin in Saccharomyces cerevisiae

Journal of Environmental Pathology, Toxicology and Oncology

Volumn 23, Issue 2, 2004, Pages 139-144

  Bala, Madhu ^a   Goel, Harish Chandra ^a  

^a INSTITUTE OF NUCLEAR MEDICINE AND ALLIED SCIENCES   (India)

Author keywords

Mutagenesis; Podophyllotoxin; Radioprotection; Recombinogenesis; Saccharomyces cerevisiae

Indexed keywords

COBALT 60; PODOPHYLLOTOXIN; PLANT EXTRACT; RADIOPROTECTIVE AGENT;

ARTICLE; COBALT THERAPY; DOSE RESPONSE; IRRADIATION; NONHUMAN; PRIORITY JOURNAL; RADIATION PROTECTION; SACCHAROMYCES CEREVISIAE; YEAST CELL; DRUG EFFECT; GAMMA RADIATION; HUMAN; PHYSIOLOGY; PHYTOTHERAPY; PODOPHYLLUM; RADIATION EXPOSURE; RADIATION RESPONSE;

EUKARYOTA; PODOPHYLLUM; SACCHAROMYCES CEREVISIAE; SINOPODOPHYLLUM HEXANDRUM;

DOSE-RESPONSE RELATIONSHIP, RADIATION; GAMMA RAYS; HUMANS; PHYTOTHERAPY; PLANT EXTRACTS; PODOPHYLLOTOXIN; PODOPHYLLUM; RADIATION-PROTECTIVE AGENTS; SACCHAROMYCES CEREVISIAE;

EID: 2942574928     PISSN: 07318898     EISSN: None     Source Type: Journal    
DOI: 10.1615/JEnvPathToxOncol.v23.i2.60     Document Type: Article

References (16)

1. Goel HC, Prashad J, Sharma AK. Protective effect of podophyllum against radiation damage. Adv Radiat Biol Peace UPZS Suppl 1990; 2:27-33.
2. Kalpan IW. Condyloma acuminata, N Orleans Med Surg J 1942; 94:388-390.
3. Cobb MW. Human papilloma virus infection. J Am Acad Dermatol 1990; 22:547-566.
4. Gowdey G, Lee RK, Carpenter WM. Treatment of HIV-related hairy leukoplakia with podophyllum resin 25% solution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995; 79:64-67.
5. Reynolds JEF, Prasad AB, editors. Martindale: The Extra Pharmacopoeia, 28 ed. London: Pharmaceutical Press, 1982.
6. Luduena RF, Roach MC. Interaction of tubulin with drugs and alkylating agents, 2. Effects of colchicine, podophyllotoxin, and vinblastine on the alkylation of tubulin. Biochemistry 1981; 20: 4444-4450.
7. Long BH, Musial ST, Brattain MG. Comparison of cytotoxicity and breakage activity of congeners of podophyllotoxin including VP16-213 and VM26; a quantitative structure-activity relationship. Biochemistry 1984; 23:1183-1188.
8. Ferguson LR, Pearson A. Chromosomal changes in Chinese hamster AA8 cells caused by podophyllin, a common treatment for genital warts. Mutat Res 1992; 266:231-239.
9. Bala M, Jain V. 2-DG induced modulation of chromosomal DNA profile, cell survival, mutagenesis and gene conversion in X-irradiated yeast. Indian J Exp Biol 1996; 34:18-26.
10. Bala M, Jain V. 2-Deoxy-D-glucose induced modulation of DNA damage repair, survival, mutagenesis, recombinogenesis in 8-MOP+UVA treated yeast. Indian J Biochem Biophys 1997; 34: 483-493.
11. Bala M, Sharma AK, Goel HC. Effects of 2-Deoxy-D-glucose on DNA repair and mutagenesis in UV-irradiated yeast. J Radiat Res 2001; 42: 285-294.
12. Zimmermann FK, Kern R, Rosenberger H. A yeast strain for simultaneous detection of induced mitotic crossing over, mitotic gene conversion and reverse mutation. Mutat Res 1975; 28:381-388.
13. Arvind L, Walker DR, Koonin EV. Conserved domains in DNA repair proteins and evolution of repair systems. Nucleic Acid Res 1999; 27: 1223-1242.
14. Schilstra MJ, Martin SR, Bayley PM. The effect of podophyllotoxin on microtubule dynamics. J Biol Chem 1989; 264:8827-8834.
15. Hammonds LR, Denyer SP, Jakson DE, Irving WL. Studies to show that with podophyllotoxin the early replicative stages of herpes simplex virus type 1 depend upon functional cytoplasmic microtubules. Acta Microbiol 1996; 45:167-172.
16. Burnburg G, Williamson DH. The relevance of nuclear division cycle to radio-sensitivity in yeast. Mol Gen Genet 1978; 162:277-286.