Some observations on the effect of Daflon (micronized purified flavonoid fraction of Rutaceae aurantiae) in bancroftian filarial lymphoedema

Filaria Journal

Volumn 2, Issue , 2003, Pages

  Das, L K ^a   Reddy, Subramanyam G ^b   Pani, S P ^a  

^a VECTOR CONTROL RESEARCH CENTRE   (India)

^b Government General Hospital   (India)

Author keywords

[No Author keywords available]

Indexed keywords

DAFLON; DIETHYLCARBAMAZINE; FLAVONOID; PLANT EXTRACT; RUTACEAE AURANTIAE EXTRACT; UNCLASSIFIED DRUG;

ABDOMINAL PAIN; ADULT; ARTHRALGIA; ARTICLE; BIOCHEMISTRY; CHILL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG MECHANISM; DRUG TOLERABILITY; FEMALE; FEVER; FILARIASIS; HEADACHE; HEMATOLOGICAL PARAMETERS; HUMAN; LYMPHEDEMA; MALE; MYALGIA; NAUSEA; RUTACEAE; RUTACEAE AURANTIAE; STATISTICAL SIGNIFICANCE; THORAX PAIN; VOMITING;

EID: 2942574443     PISSN: 14752883     EISSN: None     Source Type: Journal    
DOI: 10.1186/1475-2883-2-5     Document Type: Article

References (56)

1. Ottesen EA The global programme to eliminate lymphatic filariasis. Trop Med Int Health 2000, 5:591-594
2. Das PK, Pani SP and Krishnamoorthy K Prospects of elimination of lymphatic filariasis in India. ICMR Bulletin 2002, 32:41-54
3. Michael E, Bundy DAP and Grenfell BT Re-assessing the global prevalence and distribution of lymphatic filariasis. Parasitology 1996, 112:409-428
4. Das PK and Pani SP Towards elimination of lymphatic filariasis in India: Problems, challenges, opportunities and new initiatives. J Int Med Sci Acad 2000, 13:18-26
5. Ottesen EA, Duke BOL, Karam M and Behbehani K Strategies and tools for the control /elimination of lymphatic filariasis. Bull World Health Organ 1997, 75:491-503
6. Sabesan S, Palaniyandi M, Das PK and Michael E Mapping of lymphatic filariasis in India. Ann Trop Med Parasitol 2000, 94:591-606
7. Pani SP, Yuvraj J, Vanamail P, Dhanda V, Michael E, Grenfell BT and Bundy DAP Episodic adenolymphangitis and lymphoedema in patients with bancroftian filariasis. Trans R Soc Trop Med Hyg 1995, 89:72-74
8. Ramaiah KD, Vijay Kumar KN, Ramu K, Pani SP and Das PK Functional impairment caused by lymphatic filariasis in rural areas of south India. Trop Med Int Health 1997, 2:832-838
9. World Health Organization The state of world health. World Health Report-Bridging the gaps (WHO, Geneva) 1995, 1:42
10. Ramaiah KD, Das PK, Michael E and Guyatt H The Economic Burden of Lymphatic Filariasis in India. Parasitology Today 2000, 16:251-253
11. Centre for Disease Control (CDC) Recommendations of the International Task Force for Disease Eradication. Morbidity and Mortality Weekly Report 1993, 42:1-38
12. World Health Organization Resolution of the Executive Board of the WHO: Elimination of Lymphatic Filariasis as a Public Health Problem. Fiftieth World Health Assembly, Geneva WHA 50.29:13 May 1997
13. Dreyer G, Addiss D, Bettinger J, Dreyer P, Noroes J and Rio F Introduction. Lymphoedema Staff Manual: Treatment and Prevention of problems Associated with Lymphatic Filariasis (WHO, Geneva) 2000, v-vii
14. Ottesen EA, Ismail MM and Horton J The role of Albendazole in programmes to eliminate lymphatic filariasis. Parasitology Today 1999, 15:382-386
15. Pani SP, Subramanyam Reddy G, Das LK, Vanamail P, Hoti SL, Ramesh J and Das PK Tolerability and efficacy of single dose albendazole, diethylcarbamazine (DEC) or co-administration of albendazole with DEC in the clearance of Wuchereria bancrofti in asymptomatic microfilaraemic volunteers in Pondicherry, South India: a hospital-based study. Filaria Journal 2002, 1:[http://www.Filariajournal.com/content/1/1/1]
16. Dreyer G, Noroes J, Figueredo-Silva J and Piessens WF Pathogenesis of Lymphatic Disease in Bancroftian Filariasis: A Clinical Perspective. Parasitology Today 2000, 16:544-548
17. Das PK and Pani SP Towards elimination of lymphatic filariasis in India, problems, challenges, opportunities and new initiatives. J Int Med Sci Acad 2000, 13:18-26
18. BIO-GARD Drug acting on alimentary system. Current Index of Medical Specialities 1998, 21:56-95
19. Pecking AP, Fevier B, Wargon C and Pillion G Efficacy of Daflon 500 mg in the treatment of lymphedema (secondary to conventional therapy of breast cancer). Angiology 1997, 48:93-98
20. Le Deyehat C, Khodabandehlou T, Vimeux M and Kempf C Evaluation of haemorrhagical and microcirculatory disturbances in chronic venous insufficiency: activity of Daflon 500 mg. Int J Microcirc Clin Exp 1997, 17(Suppl 1):27-33
21. Cospite M Double-blind placebo-controlled evaluation of clinical activity and safety of Daflon 500 mg in the treatment of acute hemorrhoids. Angiology 1994, 45:566-573
22. Meyer OC Safety and security of Daflon 500 mg in venous insufficiency and in hemorrhoidal disease. Angiology 1994, 45:579-584
23. Colgan MP, Moore DJ and Shanik DG New approaches in the medical management of venous ulceration. Angiology 1993, 44:138-142
24. Guilhou JJ, Debure O, Marzin L, Ouvry P, Zuccarelli F, Debure C, Van Landuyt H, Gillet-Terver MN, Guillot B, Levesque H, Mignot J, Pillion G, Fevrier F and Dubeaux D Efficacy of Daflon 500 mg in venous leg ulcer healing: a double-blind, randomized, controlled versus placebo trial in 107 patients. Angiology 1997, 48:77-85
25. Struckmann JR Clinical efficacy of micronized flavonoid fraction: an overview. J Vasc Res 1999, 36(Suppl 1):37-41
26. Pecking AP Evaluation by lymphoscintigraphy of the effect of a micronized flavonoid fraction (Daflon 500 mg) in the treatment of upper limb lymphedema. Int Angiol 1995, 14(Suppl 1):39-43
27. Pani SP, Srividya A and Rajagopalan PK Clinical manifestations of bancroftian filariasis in relation to microfilaraemic and Diethylcarbamazine therapy. The National Medical Journal of India 1991, 4:9-14
28. Pani SP and Dhanda V Natural history and dynamics of progression of clinical manifestation of filariasis. In: Tropical Disease: Molecular Biology and Control Strategies (Edited by: Kumar S, Sen AK, Dutta GP, Sharma RN) Publication and Information Directorate, CSIR, New-Delhi 1994, 1-8
29. Pani SP and Lall R Clinical features, pathogenesis and management of lymphatic filariasis. ICMR Bulletin 1998, 28:41-51
30. Hoti SL, Elango A, Radjame K, Yuvraj J and Pani SP Utility of filter paper samples in the detection of day blood filarial antigens by Og4C3 ELISA test: sensitivity during different periods of the day. The National Medical Journal of India 2002, 15:197-201
31. World Health Organization Informal consultation on evaluation of morbidity in lymphatic filariasis. WHO/TDR/FIL/MAD/92.3 1992, 1-8
32. World Medical Association Declaration of Helsinki - Recommendations guiding physicians in biomedical research involving human subjects. In: WHO Technical Report Series, No. 850, Annex 3 1995, 30-33 [http://www.who.int/medicines/library/par/ggcp/GCPGuidePharmatrials.pdf]
33. World Health Organization Guidelines for good clinical practice (GCP) for trials on pharmaceutical products. WHO Technical Report Series, No. 850, Annex 3 1995, http://www.who.int/medicines/library/par/ggcp/GCPGuidePharmatrials.pdf
34. Indian Council of Medical Research Statement of general principles on ethical considerations involving human subjects In: Ethical guidelines for biomedical research on human subjects 2000, 1-8
35. Pani SP, Vanamail P and Yuvraj J Limb circumference measurement for recording edema volume in patients with filarial lymphedema. Lymphology 1995, 28:57-63
36. Ministry of Health and Family Welfare Government of India National Health Policy 2002, [http://mohfw.nic.in/np2002.htm]
37. Binoy C, Govardha Rao V, Ananthakrishnan N, Kate V, Yuvraj J and Pani SP Omentoplasty in the management of filarial lymphoedema. Trans R Soc Trop Med Hyg 1998, 92:317-319
38. Govardhan Rao V, Ananthakrishnan N, Pani SP, Kate V, Yuvraj J and Krishnamoorthy K Factors influencing response to lymphonodo-venous shunt in filarial lymphoedema. The National Medical Journal of India 1999, 12:55-58
39. Foldi E, Foldi M and Clodius L The lymphoedema Chaos: A Lancet. Annals of Plastic Surgery 1989, 22:505-515
40. Zelikovski A, Deutsch A and Reiss R The sequential pneumatic compression device in surgery for lymphedema in the limbs. J Cardiovas Surg (Tarino) 1993, 24:122-126
41. Vector Control Research Centre Brugian filariasis and its control in Cherthala, Kerala state. Annual Report 1994, 14-18
42. Manjula Y, Kate V and Ananthkrishnan N Evaluation of sequential intermittent pneumatic compression in filarial lymphoedema. The National Medical Journal of India 2002, 15:192-194
43. Pani SP, Yuvraj J and Vijayalakshmi Medical Management of lymphatic filariasis. A manual for clinicians (Vector Control Research Centre, Misc. publication) 1997, 21:1-25
44. Casley-Smith JR, Jamal S and Casley-Smith R Judith Reduction of filaritic lymphoedema and elephantiasis by 5, 6-benzo-alphapyrone (coumarin), and the effects of Diethylcarbamazine (DEC). Ann Trop Med & Parasitol 1993, 87:247-258
45. Casley-Smith JR, Wang CT and Zi-hai Cui Treatment of filarial lymphoedema and elephantiasis with 5, 6-benzo-alpha-pyrone (coumarin). BMJ 1993, 307:1037-1041
46. World Health Organization "Coumarin (Lodema)." WHO Pharmaceutical Newsletter 1996, 10:2
47. Partono F Filariasis in Indonesia. Clinical manifestations and basic concepts of treatment and control. Trans R Soc Trop Med Hyg 1984, 75:9-12
48. Pani SP, Krishnamoorthy K, Prathibha J and Rao AS Diethylcarbamazine and supportive measures for the treatment of Brugian filariasis. The National Medical Journal of India 1989, 2:260-263
49. Freedman David D, Bui Thuy, De Almeida Fiho Paulo, Braga Cynthia, Mala e Silva Maria Carmelita, Maciel Amelia and Furtado Aadre E Lymphoscintigraphic assessment of the effect of Diethylcarbamazine treatment on lymphatic damage in human bancroftian filariasis. Am J Trop Med Hyg 1995, 52:258-261
50. Shenoy RK, Suma TK, Rajan K and Kumaraswami V Prevention of acute adenolymphangitis in brugian filariasis: comparison of the efficacy of ivermectin and Diethylcarbamazine, each combine with local treatment of the affected limb. Ann Trop Med Parasitol 1998, 92:587-594
51. Shenoy RK, Kumaraswami V, Suma TK, Rajan K and Radhakuttyamma G A double blind placebo-controlled study, of efficacy of oral penicillin, diethylcarbamazine, or local treatment of the affected limb in preventing acute adenolymphangitis in lymphoedema caused by brugian filariasis: Ann Trop Med Parasitol 1999, 93:367-377
52. Das PK, Ramaiah KD, Vanamail P, Pani SP, Yuvraj J, Balarajan K and Bundy DAP Placebo-controlled community trial of four cycles of single dose Diethylcarbamazine or ivermectin against Wuchereria bancrofti infection and transmission in India. Trans R Soc Trop Med Hyg 2001, 95:336-341
53. Filis FA, Georgopoulis SE, Papas SC, Votteas V and Bastounis FA Therapeutic efficacy of flavonoids in oedema following reperfusion on acutely ischaemic legs. Int Angiol 1999, 18:327-30
54. Godeberge P Daflon 500 mg in the treatment of hemorrhoidal disease: a demonstrated efficacy in comparison with placebo. Angiology 1994, 45:574-578
55. Olszewski WL Treatment and complications of lymphoedema. Atlas of the lymphatics of the lower limbs 2000, 67-94
56. Directorate of National Malaria Eradication Programme National Filariasis Control Programme India. Operational Manual 1995, 1-127