Molecular cloning and characterization of the promoter region of the human Phox2b gene

Molecular Brain Research

Volumn 125, Issue 1-2, 2004, Pages 29-39

  Hong, Seok Jong ^a   Chae, Han ^a   Kim, Kwang Soo ^a  

^a MCLEAN HOSPITAL   (United States)

Author keywords

Cell type specific transcription; Cellular and molecular biology; Gene structure and function: general; Neurotransmitter identity; Noradrenergic neuron; Phox2a; Phox2b; Promoter; Transcription start site

Indexed keywords

COMPLEMENTARY DNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PHOX2B; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL LINE; CELL TYPE; CODON; DNA SEQUENCE; GENE ACTIVITY; GENE AMPLIFICATION; GENE EXPRESSION; GENE ISOLATION; GENOME; HELA CELL; HEPATOMA CELL; HUMAN; HUMAN CELL; MOLECULAR CLONING; NERVE CELL DIFFERENTIATION; NEUROBLASTOMA; NONHUMAN; NUCLEOTIDE SEQUENCE; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; RAT; REGULATORY MECHANISM;

ANIMALS; BASE SEQUENCE; CELL LINE; CLONING, MOLECULAR; GENES, REPORTER; HOMEODOMAIN PROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; NEURONS; NOREPINEPHRINE; PROMOTER REGIONS (GENETICS); RATS; SEQUENCE ALIGNMENT; TRANSCRIPTION FACTORS;

EID: 2942563939     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbrainres.2004.02.023     Document Type: Article

References (40)

1. Adachi M., Lewis E.J. The paired-like homeodomain protein, Arix, mediates protein kinase A-stimulated dopamine beta-hydroxylase gene transcription through its phosphorylation status. J. Biol. Chem. 277:2002;22915-22924
2. Adachi M., Browne D., Lewis E.J. Paired-like homeodomain proteins Phox2a/Arix and Phox2b/NBPhox have similar genetic organization and independently regulate dopamine beta-hydroxylase gene transcription. DNA Cell Biol. 19:2000;539-554
3. Bilodeau M.L., Boulineau T., Greulich J.D., Hullinger R.L., Andrisani O.M. Differential expression of sympathoadrenal lineage-determining genes and phenotypic markers in cultured primary neural crest cells. In Vitro Cell. Dev. Biol., Anim. 37:2001;185-192
4. Brunet J.F., Pattyn A. Phox2 genes-from patterning to connectivity. Curr. Opin. Genet. Dev. 12:2002;435-440
5. Ernsberger U., Reissmann E., Mason I., Rohrer H. The expression of dopamine beta-hydroxylase, tyrosine hydroxylase, and Phox2 transcription factors in sympathetic neurons: evidence for common regulation during noradrenergic induction and diverging regulation later in development. Mech. Dev. 92:2000;169-177
6. Flora A., Lucchetti H., Benfante R., Goridis C., Clementi F., Fornasari D. Sp proteins and Phox2b regulate the expression of the human Phox2a gene. J. Neurosci. 21:2001;7037-7045
7. Goridis C., Brunet J.F. Transcriptional control of neurotransmitter phenotype. Curr. Opin. Neurobiol. 9:1999;47-53
8. Goridis C., Rohrer H. Specification of catecholaminergic and serotonergic neurons. Nat. Rev., Neurosci. 3:2002;531-541
9. Guillemot F., Lo L.C., Johnson J.E., Auerbach A., Anderson D.J., Joyner A.L. Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons. Cell. 75:1993;463-476
10. Guo S., Brush J., Teraoka H., Goddard A., Wilson S.W., Mullins M.C., Rosenthal A. Development of noradrenergic neurons in the zebrafish hindbrain requires BMP, FGF8, and the homeodomain protein soulless/Phox2a. Neuron. 24:1999;555-566
11. Hirzmann J., Luo D., Hahnen J., Hobom G. Determination of messenger RNA 5′-ends by reverse transcription of the cap structure. Nucleic Acids Res. 21:1993;3597-3598
12. Hong S.J., Kim C.H., Kim K.S. Structural and functional characterization of the 5′ upstream promoter of the human Phox2a gene: possible direct transactivation by transcription factor Phox2b. J. Neurochem. 79:2001;1225-1236
13. Howard M.J., Stanke M., Schneider C., Wu X., Rohrer H. The transcription factor dHAND is a downstream effector of BMPs in sympathetic neuron specification. Development. 127:2000;4073-4081
14. Ishiguro H., Kim K.T., Joh T.H., Kim K.S. Neuron-specific expression of the human dopamine beta-hydroxylase gene requires both the cAMP-response element and a silencer region. J. Biol. Chem. 268:1993;17987-17994
15. Israel D.I. A PCR-based method for high stringency screening of DNA libraries. Nucleic Acids Res. 21:1993;2627-2631
16. Kim K.S., Ishiguro H., Tinti C., Wagner J., Joh T.H. The cAMP-dependent protein kinase regulates transcription of the dopamine beta-hydroxylase gene. J. Neurosci. 14:1994;7200-7207
17. Kim H.S., Seo H., Yang C., Brunet J.F., Kim K.S. Noradrenergic-specific transcription of the dopamine beta-hydroxylase gene requires synergy of multiple cis-acting elements including at least two Phox2a-binding sites. J. Neurosci. 18:1998;8247-8260
18. Kim C.H., Kim H.S., Cubells J.F., Kim K.S. A previously undescribed intron and extensive 5′ upstream sequence, but not Phox2a-mediated transactivation, are necessary for high level cell type-specific expression of the human norepinephrine transporter gene. J. Biol. Chem. 274:1999;6507-6518
19. Kim C.H., Hwang D.Y., Park J.J., Kim K.S. A proximal promoter domain containing a homeodomain-binding core motif interacts with multiple transcription factors, including HoxA5 and Phox2 proteins, and critically regulates cell type-specific transcription of the human norepinephrine transporter gene. J. Neurosci. 22:2002;2579-2589
20. Lim K.C., Lakshmanan G., Crawford S.E., Gu Y., Grosveld F., Engel J.D. Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system. Nat. Genet. 25:2000;209-212
21. Lo L., Tiveron M.C., Anderson D.J. MASH1 activates expression of the paired homeodomain transcription factor Phox2a, and couples pan-neuronal and subtype-specific components of autonomic neuronal identity. Development. 125:1998;609-620
22. Lo L., Morin X., Brunet J.F., Anderson D.J. Specification of neurotransmitter identity by Phox2 proteins in neural crest stem cells. Neuron. 22:1999;693-705
23. Morin X., Cremer H., Hirsch M.R., Kapur R.P., Goridis C., Brunet J.F. Defects in sensory and autonomic ganglia and absence of locus coeruleus in mice deficient for the homeobox gene Phox2a. Neuron. 18:1997;411-423
24. Pattyn A., Morin X., Cremer H., Goridis C., Brunet J.F. Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis. Development. 124:1997;4065-4075
25. Pattyn A., Morin X., Cremer H., Goridis C., Brunet J.F. The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives. Nature. 399:1999;366-370
26. Pattyn A., Goridis C., Brunet J.F. Specification of the central noradrenergic phenotype by the homeobox gene Phox2b. Mol. Cell. Neurosci. 15:2000;235-243
27. Qian Y., Fritzsch B., Shirasawa S., Chen C.L., Choi Y., Ma Q. Formation of brainstem (nor)adrenergic centers and first-order relay visceral sensory neurons is dependent on homeodomain protein Rnx/Tlx3. Genes Dev. 15:2001;2533-2545
28. Reissmann E., Ernsberger U., Francis-West P.H., Rueger D., Brickell P.M., Rohrer H. Involvement of bone morphogenetic protein-4 and bone morphogenetic protein-7 in the differentiation of the adrenergic phenotype in developing sympathetic neurons. Development. 122:1996;2079-2088
29. Schneider C., Wicht H., Enderich J., Wegner M., Rohrer H. Bone morphogenetic proteins are required in vivo for the generation of sympathetic neurons. Neuron. 24:1999;861-870
30. Seo H., Yang C., Kim H.S., Kim K.S. Multiple protein factors interact with the cis-regulatory elements of the proximal promoter in a cell-specific manner and regulate transcription of the dopamine beta-hydroxylase gene. J. Neurosci. 16:1996;4102-4112
31. Seo H., Hong S.J., Guo S., Kim H.S., Kim C.H., Hwang D.Y., Isacson O., Rosenthal A., Kim K.S. A direct role of the homeodomain proteins Phox2a/2b in noradrenaline neurotransmitter identity determination. J. Neurochem. 80:2002;905-916
32. Stanke M., Junghans D., Geissen M., Goridis C., Ernsberger U., Rohrer H. The Phox2 homeodomain proteins are sufficient to promote the development of sympathetic neurons. Development. 126:1999;4087-4094
33. Swanson D.J., Adachi M., Lewis E.J. The homeodomain protein Arix promotes protein kinase A-dependent activation of the dopamine beta-hydroxylase promoter through multiple elements and interaction with the coactivator cAMP-response element-binding protein-binding protein. J. Biol. Chem. 275:2000;2911-2923
34. Tiveron M.C., Hirsch M.R., Brunet J.F. The expression pattern of the transcription factor Phox2 delineates synaptic pathways of the autonomic nervous system. J. Neurosci. 16:1996;7649-7660
35. Valarche I., Tissier-Seta J.P., Hirsch M.R., Martinez S., Goridis C., Brunet J.F. The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype. Development. 119:1993;881-896
36. Varley J.E., McPherson C.E., Zou H., Niswander L., Maxwell G.D. Expression of a constitutively active type I BMP receptor using a retroviral vector promotes the development of adrenergic cells in neural crest cultures. Dev. Biol. 196:1998;107-118
37. Vogel-Hopker A., Rohrer H. The specification of noradrenergic locus coeruleus (LC) neurones depends on bone morphogenetic proteins (BMPs). Development. 129:2002;983-991
38. Yang C., Kim H.S., Seo H., Kim C.H., Brunet J.F., Kim K.S. Paired-like homeodomain proteins, Phox2a and Phox2b, are responsible for noradrenergic cell-specific transcription of the dopamine beta-hydroxylase gene. J. Neurochem. 71:1998;1813-1826
39. Yokoyama M., Watanabe H., Nakamura M. Genomic structure and functional characterization of NBPhox (PMX2B), a homeodomain protein specific to catecholaminergic cells that is involved in second messenger-mediated transcriptional activation. Genomics. 59:1999;40-50
40. Zellmer E., Zhang Z., Greco D., Rhodes J., Cassel S., Lewis E.J. A homeodomain protein selectively expressed in noradrenergic tissue regulates transcription of neurotransmitter biosynthetic genes. J. Neurosci. 15:1995;8109-8120