TbRAB23; a nuclear-associated Rab protein from Trypanosoma brucei

Molecular and Biochemical Parasitology

Volumn 136, Issue 2, 2004, Pages 297-301

  Dhir, Vivek ^a   Field, Mark C ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

FITC; fluorescein isothiocyanate; glutathione S transferase; GST; IFA; immunofluorescence analysis; Nucleus; open reading frame; ORF; Rab; Ran; Small G protein; Trypanosoma; Vesicle trafficking

Indexed keywords

RAB PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CELL GROWTH; CELL NUCLEUS; FLAGELLATE; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; TRYPANOSOMA BRUCEI;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; DNA, PROTOZOAN; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PHYLOGENY; PROTOZOAN PROTEINS; RAB GTP-BINDING PROTEINS; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TRYPANOSOMA BRUCEI BRUCEI;

MASTIGOPHORA (FLAGELLATES); PROTOZOA; TRYPANOSOMA; TRYPANOSOMA BRUCEI;

EID: 2942562557     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2003.12.014     Document Type: Article

References (21)

1. Short B., Preisinger C., Korner R., Kopajtich R., Byron O., Barr F.A. A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic. J. Cell Biol. 155:2001;877-883
2. Smythe E. Direct interactions between rab GTPases and cargo. Mol. Cell. 9:2002;205-206
3. Waters M.G., Pfeffer S.R. Membrane tethering in intracellular transport. Curr. Opin. Cell Biol. 11:1999;453-459
4. Pereira-Leal J.B., Seabra M.C. Evolution of the Rab family of small GTP-binding proteins. J. Mol. Biol. 313:2001;889-901
5. Bock J.B., Matern H.T., Peden A.A., Scheller R.H. A genomic perspective on membrane compartment organization. Nature. 409:2001;839-841
6. Seabra M.C. Membrane association and targeting of prenylated Ras-like GTPases. Cell Signal. 10:1998;167-172
7. Wilson A.L., Erdman R.A., Castellano F., Maltese W.A. Prenylation of Rab8 GTPase by type I and type II geranylgeranyl transferases. Biochem. J. 333(Pt. 3):1998;497-504
8. Ryan K.J., McCaffery J.M., Wente S.R. The Ran GTPase cycle is required for yeast nuclear pore complex assembly. J. Cell Biol. 160:2003;1041-1053
9. Yamaguchi R., Newport J. A role for Ran-GTP and Crm1 in blocking re-replication. Cell. 113:2003;115-125
10. Richards S.A., Lounsbury K.M., Macara I.G. The C terminus of the nuclear RAN/TC4 GTPase stabilizes the GDP-bound state and mediates interactions with RCC1, RAN-GAP, and HTF9A/RANBP1. J. Biol. Chem. 270:1995;14405-14411
11. Field M.C., Field H., Boothroyd J.C. A homologue of the nuclear GTPase Ran/TC4 from Trypanosoma brucei. Mol. Biochem. Parasitol. 69:1995;131-134
12. Buckner F.S., Yokoyama K., Nguyen L., et al. Cloning, heterologous expression, and distinct substrate specificity of protein farnesyltransferase from Trypanosoma brucei. J. Biol. Chem. 275:2000;21870-21876
13. Welman A., Burger M.M., Hagmann J. Structure and function of the C-terminal hypervariable region of K-Ras4B in plasma membrane targeting and transformation. Oncogene. 19:2000;4582-4591
14. Eggenschwiler J.T., Espinoza E., Anderson K.V. Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway. Nature. 412:2001;194-198
15. Buckner F.S., Eastman R.T., Nepomuceno-Silva J.L., et al. Cloning, heterologous expression, and substrate specificities of protein farnesyltransferases from Trypanosoma cruzi and Leishmania major. Mol. Biochem. Parasitol. 122:2002;181-188
16. Swofford DL. PAUP*. Phylogenetic analysis using parsimony (*and other methods). Version 4.0b10. Sinauer Associates, Sunderland, Massachusetts; 2002.
17. Pal A., Hall B.S., Nesbeth D.N., Field H.I., Field M.C. Differential endocytic functions of Trypanosoma brucei Rab5 isoforms reveal a glycosylphosphatidylinositol-specific endosomal pathway. J. Biol. Chem. 277:2002;9529-9539
18. Jeffries T.R., Morgan G.W., Field M.C. A developmentally regulated rab11 homologue in Trypanosoma brucei is involved in recycling processes. J. Cell Sci. 114:2001;2617-2626
19. Jeffries T.R., Morgan G.W., Field M.C. TbRAB18, a developmentally regulated Golgi GTPase from Trypanosoma brucei. Mol. Biochem. Parasitol. 121:2002;63-74
20. Rout M.P., Field M.C. Isolation and characterization of subnuclear compartments from Trypanosoma brucei. Identification of a major repetitive nuclear lamina component. J. Biol. Chem. 276:2001;38261-38271
21. Durand-Dubief M., Kohl L., Bastin P. Efficiency and specificity of RNA interference generated by intra- and intermolecular double stranded RNA in Trypanosoma brucei. Mol. Biochem. Parasitol. 129:2003;11-21