Hypoglycemic effect of macrocyclic binuclear oxovanadium (IV) complex on streptozotocin-induced diabetic rats

Experimental Diabesity Research

Volumn 5, Issue 2, 2004, Pages 137-142

  Ramachandran, B ^a   Sekar, D Sethish ^a   Kandaswamy, M ^a   Narayanan, V ^a   Subramanian, S ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Macrocyclic complex; Streptozotocin diabetes; Vanadium

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; CREATININE; GLUCOSE; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN; PROTEIN; STREPTOZOCIN; UREA; VANADIUM DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOCHEMISTRY; CONTROLLED STUDY; DIABETES MELLITUS; DIET RESTRICTION; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TOLERANCE TEST; HEART DISEASE; HYPOGLYCEMIA; KIDNEY DISEASE; LIVER DISEASE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES; WEIGHT GAIN;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; HYPOGLYCEMIC AGENTS; MALE; RATS; RATS, WISTAR; VANADATES; WEIGHT GAIN;

EID: 2942558444     PISSN: 15438600     EISSN: None     Source Type: Journal    
DOI: 10.1080/15438600490277842     Document Type: Article

References (46)

1. Macara, I. G. (1980) Vanadium: An element in search of a role. Trends. Biochem. Sci., 5, 92-94.
2. Srivastava, A. K. (1995) Potential use of vanadium compounds in the treatment of diabetes mellitus. Exp. Opin. Invest. Drugs., 4, 525-536.
3. Brichard, S. M., and Henquin, J. C. (1995) The role of vanadium in the management of diabetes. Trends Pharmacol. Sci., 16, 265-270.
4. Poucheret, P., Subodh, V., Grynpas, M. D., and McNeill, J. H. (1998) Vanadium and diabetes. Mol. Cell. Biochem., 188, 73-80.
5. Schechter, Y., and Karlion, S. J. D. (1980) Insulin-like stimulation of glucose oxidation in rat adipocytes by vanadyl (IV) ions. Nature, 284, 556-558.
6. Shafrir, E., Spielman, S., Nachliel, I., Khamaisi, M., Bar-On, H., and Ziv, E. (2001) Treatment of diabetes with vanadium salts: General overview and amelioration of nutritionally induced diabetes in the Psammomys obesus gerbil. Diabetes Metab. Res. Rev., 17, 55-66.
7. Dubyak, G. R., and Kleinzeller, A. (1980) The insulin-mimetic effects of vanadate in isolated rat adipocytes. J. Biol. Chem., 255, 5306-5312.
8. Degani, H., Gochin, M., Karlish, S. J. D., and Schechter, Y. (1981) Electron paramagnetic studies and insulin-like effects of vanadate in rat adipocytes. Biochemistry, 20, 5795-5799.
9. Schechter, Y. (1990) Perspectives in diabetes, insulin-mimetic effects of vanadate. Possible implications for future treatment of diabetes. Diabetes, 39, 1-5.
10. Heyliger, E. C., Tahilini, G. A., and McNeill, H. J. (1985) Effect of vanadate on elevated blood glucose and depressed cardiac performance of diabetic rats. Science, 227, 1474-1476.
11. Ramanadham, S., Mongold, J. J., Brownsey, R. W., Cors, G. H., and McNeill, J. H. (1989) Oral vanadyl sulfate in treatment of diabetes mellitus in rats. Am. J. Physiol., 257, H904-H911.
12. Sakurai, H., Tsuchiya, K., Nukatsuka, M., Kawada, J., Ishikawa, S., Yoshida, H., and Komatsu, M. (1990) Insulin-mimetic action of vanadyl complexes. J. Clin. Biochem. Nutr., 8, 193-200.
13. McNeill, J. H., Yuen, V. G., Hoveyda, H. R., and Chris, O. (1992) Bis- (maltolato) oxovanadium (IV) is a potent insulin mimic. J. Med. Chem., 35, 1489-1491.
14. Nandhini, D., Maneemegalai, S., Elangovan, V., Sekar, N., and Govindasamy, S. (1993) Insulin like effects of bis-glycinato oxovanadium (IV) complex on experimental diabetic rats. Indian J. Biochem. Biophys., 30, 73-76.
15. Watanabe, H., Nakai, M., Komazawa, K., and Sakurai, H. (1994) Bis-pyrrolidin-N -carbodithiato oxovanadium (IV) is a potent insulin mimic. J. Med. Chem., 37, 876-877.
16. Sekar, N., Li, J., and Schechter, Y. (1996) Vanadium salts as insulin substitutes: Mechanism of action, a scientific and therapeutic tool in diabetes mellitus research. Crit. Rev. Biochem. Mol. Biol., 31, 339-359.
17. Domingo, J. L., Llobet, J. M., Tomas, J. M., and Corbella, J. (1985) Short term toxicity studies of vanadium in rats. J. Appl. Toxicol., 5, 418-421.
18. Shanchez, D. J., Ortega, A., Domingo, J. L., and Corbella, J. (1991) Developmental toxicity evaluation of sodium orthovanadate in the mouse. Biol. Trace Elem. Res., 30, 219-229.
19. V complexes: Synthesis, structure, electrochemistry and magneto chemistry. J. Inorg. Chem., 34, 2861-2869.
20. Meyerovitch, J., Farfel, Z., Sack, J., and Schechter, Y. (1987) Oral administration of vanadate normalizes blood glucose levels in streptozotocin treated rats. J. Biol. Chem., 262, 6658-6662.
21. Sasaki, T., Matsy, S., and Sonae, A. (1972) Effect of acetic acid concentration on the colour reaction in the O-toluidine boric acid method for blood glucose estimation. Rinsh. Kagaku., 1, 346-353.
22. Natelson, S., Scott, M. L., and Begga, E. (1951) A rapid method for the estimation of urea in biological fluids by means of the reaction between diacetyl and urea. Am. J. Clin. Pathol., 21, 275-281.
23. Drabkin, D. L., and Austin, J. M. (1932) Spectrophotometric constants for common hemoglobin derivatives in human, dog and rabbit blood. J. Biol. Chem., 98, 719-733.
24. Nayak, S. S., and Pattabiraman, T. N. (1981) A new colorimetric method for the estimation of glycosylated hemoglobin. Clin. Chem. Acta, 109, 267-274.
25. Zlatkis, A., Zak, B., and Boyle, A. J. (1953) Method for the determination of serum cholesterol. J. Clin. Medicare, 41, 486-490.
26. Brod, J., and Sirota, J. H. (1948) Renal clearance of endogenous creatinine in man. J. Clin. Invest., 27, 645.
27. Lowry, O. H., Rosenbrough, N. J., Farr, A. L., and Randall, R. (1951) Protein determination using Folin-Ciocalteu Reagent. J. Biol. Chem., 193, 265.
28. King, J. (1965) The transferase-alanine and aspartate transaminase. In: Practical Clinical Enzymology, Edited by Princeton, M. J., pp. 363-395. London, Van D Wostrand.
29. Whittington, K. B., Solomon, S. S., and Lu, Z. N. (1991) Islet allograft in the cryptorchid testes of spontaneously diabetic BB/W or dp rats: Response to glucose, glipizide and arginine. Endocrinology, 128, 2671-2677.
30. Pari, L., and Umamaheswari, J. (1999) Antihyperglycaemic activity of Musa sapeintum L. in alloxan-induced diabetic rats. J. Ethnopharmacol., 68, 1-5.
31. Schwarz, K., and Milne, D. B. (1971) Growth effects of vanadium in the rat. Science, 174, 426-428.
32. Sakurai, H., Tsuchiya, K., Nukatsuka, M., Sofue, M., and Kawada, J. (1990) Insulin-like effect of vanadyl ion on streptozotocin-induced diabetic rats. J. Endocrinol., 126, 451-459.
33. Ramachandran, B., Kandasamy, M., Narayanan, V., and Subramanian, S. (2003) Insulin mimetic effects of macrocyclin binuclear oxovanadium complexes on STZ-induced experimental diabetes in rats. Diabetes Obesity Metab., 5, 455-461.
34. Sekar, N., and Govindasamy, S. (1991) Effects of vanadate on plasma lipoprotein profiles in experimental diabetic rats. Biochem. Int., 23, 935-940.
35. Valera, A., Rodriguez-Gil, J. E., and Bosch, F. (1993) Vanadate treatment restores the expression of genes for key enzymes in the glucose and ketone bodies metabolism in the liver of diabetic rats. J. Clin. Invest., 92, 4-11.
36. Alberti, K. G. M. M., and Press, C. M. (1982) The biochemistry and the complications of diabetes. In: Comlications of Diabetes, Edited by Keen, H., and Jarre, J., pp. 231-270. Edward Arnold, London.
37. Koenig, R. J., Peterson, C. M., Jones, R. L., Saudek, C., Lehrman, M., and Cerami, A. (1976) Correlation of glucose regulation and hemoglobin A1 C in diabetes mellitus. N. Engl. J. Med., 295, 417-420.
38. Venkateswaran, S., and Pari, L. (2002) Effect of Coccinia indica on blood glucose, insulin and hepatic key enzymes in experimental diabetes. Pharmacol. Biol., 40, 165-170.
39. Sekar, N., Kanthasamy, S., William, S., Subramanian, S., and Govindasamy, S. (1990) Insulinic action of vanadate on experimental diabetes. Pharmacol. Res., 22, 207-217.
40. Rannels, D. E., Mokee, D. E., and Morgan, H. E. (1997) Action of insulin. In: Biochemical Actions of Hormones, Edited by Lit Wack, G., pp. 135-195. New York, Academic Press.
41. Dighe, R. R., Rojas, F. J., and Birnbaumer, L. (1984) Glucagon stimulates adenylate cyclase in rat liver. The impact of STZ-induced diabetes mellitus. J. Clin. Invest., 73, 1013-1024.
42. Morris, G., and Leon, L. M. (1960) Protein metabolism and protein synthesis in perfused livers of normal and alloxan diabetic rats. J. Biol. Chem., 235, 3202-3208.
43. Hansen, T. V., Aaseth, J., and Alexander, J. (1982) The effect of chelating agents on vanadium distribution in rat body and on uptake by human erythrocytes. Arch. Toxicol., 50, 195-198.
44. Jandhyala, B. S., and Hom, G. J. (1983) Physiological and pharmacological properties of vanadium. Life Sci., 33, 1325-1331.
45. Rao, G. M., Morghom, L. O., Kabur, M. N., Ben Mohmud, B. M., and Ashibani, K. (1989) Serum glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) levels in diabetes mellitus. Indian J. Med. Sci., 43, 118-121.
46. Scott, F. W., Trick, K. D., Lee, L. P., Hynie, I., Heick, H. M., and Nera, E. A. (1984) Serum enzymes in the BB rat before and after onset of the overt diabetic syndrome. Clin. Biochem., 17, 270-275.