Heme-oxygenase-1 expression correlates with severity of acute cellular rejection in lung transplantation

Journal of the American College of Surgeons

Volumn 198, Issue 6, 2004, Pages 945-952

  Bonnell, Mark R ^a   Visner, Gary A ^a   Zander, Dani S ^b   Mandalapu, Subbarao ^a   Kazemfar, Kristy ^a   Spears, Linnea ^a   Beaver, Thomas M ^a,c  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF FLORIDA   (United States)

Author keywords

ACR; acute cellular rejection; cobalt protoporphyrin; CoPP; heme oxygenase 1; HO 1; MPO; myeloperoxidase; SnPP; tin protoporphyrin

Indexed keywords

ENZYME INDUCING AGENT; HEME OXYGENASE 1; HEME OXYGENASE INHIBITOR; METALLOPORPHYRIN; MYELOPEROXIDASE; PORPHYRIN COBALT; PROTOPORPHYRIN TIN; UNCLASSIFIED DRUG;

ACUTE GRAFT REJECTION; ALLOGRAFT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; ENZYME ACTIVITY; IMMUNOHISTOCHEMISTRY; ISCHEMIA; LUNG TRANSPLANTATION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; WESTERN BLOTTING;

ANIMALS; GRAFT REJECTION; HEME OXYGENASE (DECYCLIZING); HEME OXYGENASE-1; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG TRANSPLANTATION; MALE; MEMBRANE PROTEINS; OXIDATIVE STRESS; PEROXIDASE; RATS; RATS, INBRED LEW; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY;

EID: 2942552338     PISSN: 10727515     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jamcollsurg.2004.01.026     Document Type: Article

References (34)

1. Hosenpud J.D., Bennet L.E., Keck B.M., et al. The registry for the international society of heart and lung transplantation sixteenth annual report. J Heart and Lung Transplant. 18:1999;611-626
2. Bando K., Paradis I.L., Keenan R.J., et al. Obliterative bronchiolitis after lung and heart-lung transplantation. J Thorac Cardiovasc Surg. 110:1995;4-14
3. Fiser S.M., Tribble C.G., Long S.M., et al. Ischemia-reperfusion injury after lung transplantation increases the risk of late bronchiolitis obliterans syndrome. Ann Thorac Surg. 73:2002;1041-1048
4. Baz M.A., Layish D.T., Govert J.A., et al. Diagnostic yield of bronchoscopic biopsies after isolated lung transplantation. Chest. 110:1996;84-88
5. Kutty R.K., Kutty G., Nagineni C.N., et al. RT-PCR assay for heme oxygenase-1 and heme oxygenase-2 a sensitive method to estimate cellular oxidative damage. Ann NY Acad Sci. 1998;427-430
6. Vile G.F., Tyrell R.M. Oxidative stress resulting from ultraviolet a irradiation of human skin fibroblasts leads to a heme oxygenase-dependent increase in ferritin. J Biol Chem. 268:1993;14678-14681
7. Abraham N.G., Lavrovsky Y., Schwartzman M.L., et al. Transfection of the human heme oxygenase gene into rabbit coronary microvessel endothelial cells protective effect against heme and hemoglobin toxicity. Proc Natl Acad Sci USA. 92:1995;6798-6802
8. Vogt B.A., Alam J., Croatt A.J., et al. Acquired resistance to acute oxidative stress possible role of heme oxygenase and ferritin. Lab Invest. 72:1995;474-483
9. Visner G.A., Fogg S., Nick H.S. Hyperoxia-responsive proteins in rat pulmonary microvascular endothelial cells. Am J Physiol. 270:1996;L517-L525
10. Bach F.H., Ferran C., Hechenleitner P., et al. Accommodation of vascularized xenografts expression of "protective genes" by donor endothelial cells in a host TH2 cytokine environment. Nature Med. 3:1997;196-204
11. Hancock W.W., Buelow R., Sayegh M.H., Turka L.A. Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes. Nature Med. 4:1998;1392-1396
12. Miyatake R., Koyamada H., Hancock W.W., et al. Survival of accommodated cardiac xenografts upon retransplantation into cyclosporine-treated recipients. Transplantation. 65:1998;1563-1569
13. Amersi F., Buelow R., Kato H., et al. Upregulation of heme oxygenase-1 protects genetically fat Zucker rat livers from ischemia/reperfusion. J Clin Invest. 104:1999;1631-1639
14. Lu F., Zander D.S., Visner G.A. Increased expression of heme oxygenase 1 in lung transplantation. J Heart Lung Transplant. 21:2002;1120-1126
15. Visner G.A., Lu F., Zhou H., et al. Graft protective effects of heme oxygenase 1 in mouse tracheal transplant-related obliterative bronchiolitis. Transplantation. 76:2003;650-656
16. Mizuta T., Kawaguchi A., Nakahara K., Kawashima Y. Simplified rat lung transplantation using a cuffed technique. J Thorac Cardiovasc Surg. 97:1989;578-581
17. Maines M.D., Trakshel G.M. Differential regulation of heme oxygenase isozymes by Sn- and Zn- protoporphyrins possible relevance to suppression of hyperbilirubinemia. Biochem Biophys Acta. 1992;1131-1166
18. Yousem Y., Berry G.J., Cagle P.T., et al. Revision of the 1990 working formulation for the classification of pulmonary allograft rejection lung rejection study group. J Heart Lung Transplant. 15:1996;1-15
19. Katori M., Buelow R., Ke B., et al. Heme-oxygenase-1 overexpression protects rat hearts from cold ischemia-reperfusion injury via an apoptotic pathway. Transplantation. 73:2002;287-292
20. Maines M.D. The hemeoxygenase system a regulator of second messenger gases. Annu Rev Pharmacol Toxicol. 37:1997;517-554
21. Stocker R., Yamamoto Y., McDonagh A.F., et al. Bilirubin is an anti-oxidant of possible physiological importance. Science. 235:1987;1043-1046
22. Otterbein L.E., Mantell L.L., Choi A.M. Carbon monoxide provides protection against hyperoxic lung injury. Am J Physiol. 276:1999;L688-L694
23. Morita T., Perella M.A., Lee M.E., Kourembanas S. Smooth muscle cell derived-carbon monoxide is a regulator of vascular cGMP. Proc Natl Acad Sci USA. 92:1995;1475-1479
24. Fujita T., Toda K., Karimova A., et al. Paradoxical rescue from ischemic lung injury by inhaled carbon monoxide driven by derepression of fibrinolysis. Nat Med. 7:2001;598-604
25. Anderson K.E., Simionatto C.S., Drummond G.S., Kappas A. Tissue distribution and disposition of tin protoporphyrin, a potent competitive inhibitor of heme oxygenase. J Pharmacol Exp Ther. 228:1984;327-333
26. Drummond G.S., Kappas A. The cytochrome P-450 depleted animal an experimental model for in vivo studies in chemical biology. Proc Natl Acad Sci USA. 79:1982;2384-2388
27. Otterbein L., Chin B.Y., Otterbein S.L., et al. Mechanism of hemoglobin-induced protection against endotoxemia in rats a ferritin-independent pathway. Am J Physiol. 272:1997;268-275
28. Mosley K., Wembridge D.E., Cattell V., Cook H.T. Heme oxygenase is induced in nephrotoxic nephritis and hemin, a stimulator of heme oxygenase synthesis, ameliorates disease. Kidney Int. 53:1998;672-678
29. Willis D., Moore A.R., Frederick R., Willoughby D.A. Heme oxygenase a novel target for the modulation of the inflammatory response. Nature Med. 2:1996;87-90
30. Brouard S., Cristina M., Cuturi C., et al. Prolongation of heart xenograft survival in a hamster to rat model after therapy with a rationally designed immunosuppressive peptide. Transplantation. 67:1999;1614-1618
31. Soares M., Lin Y., Anrather J., et al. Expression of heme oxygenase-1 can determine cardiac xenograft survival. Nature Med. 4:1998;1073-1077
32. Cuturi M.C., Christoph F., Woo J., et al. RDP1258, a new rationally designed immunosuppressive peptide, prolongs allograft survival in rats analysis of its mechanism of action. Mol Med. 5:1999;820-832
33. Song R., Zhou Z., Dauber J.H., et al. Carbon monoxide induces cytoprotection in rat orthotopic lung transplantation via anti-inflammatory and anti-apoptotic effects. Am J Pathol. 163:2003;231-242
34. Suttner D.M., Dennery P.A. Reversal of HO-1 related cytoprotection with increased expression is due to reactive iron. FASEB J. 13:1999;1800-1809