Production of validamycins from crude substrates by streptomyces hygroscopicus in an external-loop airlift bioreactor with a low height-to-diameter ratio

Chinese Journal of Chemical Engineering

Volumn 12, Issue 1, 2004, Pages 102-107

  Zheng, Yuguo ^a   Chen, Xiaolong ^a   Wang, Zhao ^a   Shen, Yinchu ^a  

^a ZHEJIANG UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Airlift bioreactor; Streptomyces hygroscopicus; Validamycins

Indexed keywords

EID: 2942547971     PISSN: 10049541     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Woragidbumrung, K., Sae-Tang, P., Yao, H., Han, J., Chaivatcharin, S., Zhong, J.J., Impact of conditioned medium on cell cultures of Panax notoginseng in an airlift bioreactor, Process Biochem., 37, 209-213 (2001).
2. Huang, T.K., Wang, P.M., Wu, W.T., Cultivation of Bacillus thuringiensins in airlift reactor with wire mesh draft tubes, Biochem. Eng. J., 7, 35-39 (2001).
3. Gavrilescu, M., Tudose, R.Z., Hydrodynamics of non-Newtonian liquids in external-loop airlift bioreactors. Part I: Study of the gas holdup, Bioproc. Eng., 18, 17-26 (1998).
4. Galindez-Mayer, J., Sanchez-Teja, O., Cristiani-Urbina, E., Ruiz-Ordaz, N., A novel split-cylinder airlift reactor for fed-batch cultures, Bioproc. Biosys. Eng., 24, 171-177 (2001)
5. Bello, R.A., Robinson, C.W., Moo-young, M., Gas holdup and overall volumetric oxygen transfer coefficient in airlift contactors, Biotechnol. Bioeng., 27, 369-381 (1985).
6. Sajc, L., Oberadovic, B., Vakovic, D., Bugarki, B., Hydrodynamics and mass transfer in a four-phase external-loop airlift bioreactor, Biotechnol. Prog., 11, 420-428 (1995).
7. Kawase, Y., Hashimoto, N., Gas hold-up and oxygen transfer in three-phase external-loop airlift bioreactors: Non-Newtonian fermentation broths, J. Chem. Tech. Biotechnol., 65, 325-334 (1996).
8. Kawase, Y., Omori, N., Tsujimura, M., Liquid-phase mixing in external-loop airlift bioreactors, J. Chem. Tech. Biotechnol., 61, 49-55 (1994).
9. Fraser, R.D., Itiel, G.A., Hydrodynamic characteristic of a spinning sparger, external-loop airlift bioreactor, Can. J. Chem. Eng., 71, 419-425 (1993).
10. Fraser, R.D., Ritchie, B.J., Hill, G.A., Dynamic mixing and oxygen transfer in a small airlift loop bioreactors: Model and experimental verification, Biotechnol. Prog., 10, 543-547 (1994).
11. Gavrilescu, M., Tudose, R.Z., Modeling of liquid circulation velocity in concentric tube airlift reactors, Chem. Eng. J., 69, 85-91 (1998).
12. Zheng, Y.G., Wang, Z., Chen, X.L., α-Amylase production by Bacillus subtilis with dregs in an external-loop airlift bioreactor, Biochem. Eng. J., 5, 115-121 (2000).
13. Schorr-Galindo, S., Ghomnidh, C., Guiraud, J.P., Insulin enrichment by fermentation in a flocculating yeast reactor, Biotechnol. Lett., 17, 1305-1310 (1995).
14. Chung, I.S., Kang, Y.M., Oh, J.H., Continuous suspended cell culture of Mentha piperita in cell-recycled airlift bioreactor, Biotechnol. Tech., 8, 789-792 (1994).
15. Kessler, W.R., Popovic, M.K., Robinson, C.W., Xanthan production in an external-loop airlift fermenter, Can. J. Chem. Eng., 71, 101-106 (1993).
16. Brandes, L., Cvu, X., Maschke, H.S., Production of fusion protein SPA ECORI in batch culture in a 60 L airlift tower loop reactor, Biotechnol. Prog., 9, 122-127 (1993).
17. Al-Qodah, Z., Lsfi, W., Modeling of antibiotics production in magneto three-phase airlift fermenter, Biochem. Eng. J., 7, 7-16 (2001).
18. Xie, D., Liu, D., Liu, T., Modeling of glycerol production by fermentation in different reactor states, Process Biochem., 36, 1225-1232 (2001).
19. Mekchuk, J.C., Siegel, M.H., Airlift reactors in chemical and biological technology, J. Chem. Tech. Biotechnol., 41, 105-120 (1988).
20. Agricultural Antibiotic Group in Shanghai Pesticide Institute, Identification of validamycins producing organism, Ac. Microb., 15, 110-114 (1975). (in Chinese)
21. Iwasa, T., Higashide, E., Yamanoto, H., Shibata, M., Studies on validamycins, a new antibiotic H. Production and biological properties of validamycins A and B, J. Antibiot., 24, 107-113 (1971).
22. Dong, H., Mahmud, T., Tornus, I, Lee, S., Floss, H., Biosynthesis of the validamycins: Identification of intermediates in the biosynthesis of validamycin A by Streptomyces hygroscopic us, J. Am. Chem. Soc., 123, 2733-2742 (2001)
23. Iwasa, T., Yamamoto, H., Shibata, M., Studies on validamycins new antibiotics L Streptomyces hygroscopicus var. Limoneusnov. var., validamycin producing organism, J. Antibiot., 23, 595-602 (1970)
24. Kameda, Y., Asano, N., Matsui, K., Structures of minor components of the validamycin complex, J. Antibiot., 41, 1488-1492 (1988).
25. Asano, N., Yamaguchi, T., Kameda, Y., Matsui, K., Effect of validamycins on glycohydrolases of Rhizoctionia Solani, J. Antibiot., 40, 526-532 (1987).
26. Chen, T., Zhang, Y., Sun, S., Determination of the Biological Pesticides and Their Principles, Agriculture Press, Beijing (1993). (in Chinese)
27. Jia, S., Mu, G., Ren, S., A rapid method for determination of reducing sugar, glucose and starch in fruits and vegetables with 3,5-diatrosarycylie acid, Food Ferment. Ind., 2, 30-34 (1983). (in Chinese)
28. Kamp, F., Wase, D.A.J., McManamey, W.J., Mendoza, O., Thayamithy, K., A comparison of some methods of estimating volumetric mass-transfer coefficients in an external-loop airlift fermenter, Biotechnol. Bioeng., 30, 179-186 (1987).
29. Stejskal, J., Potucek, F., Oxygen transfer in liquids, Biotechnol. Bioeng., 27, 503-508 (1985).
30. Snape, J.B., Fialova, M., Zahradnik, J., Hydrodynamic studies in an external-loop airlift reactor containing aqueous electrolyte and sugar solutions, Chem. Eng. Sci., 47, 3387-3394 (1992).
31. Snape, J.B., Zahradnik, J., Fialova, M., Thomas, N.H., Liquid-phase properties and sparger design effects in an external-loop airlift reactor, Chem. Eng. Sci., 50, 3175-3186 (1995).
32. Merchuk, J.C., Gas holdup and liquid velocity in a two-dimensional airlift reactor, Chem. Eng. Sci., 41, 11-16 (1986).
33. Mekchuk, J.C., Stein, Y., Local holdup and liquid velocity in airlift reactors, AIChE J., 27, 377-388 (1981).
34. McManamecy, W.J., Wase, D.A.J., Rayrnahasay, S., Thayanithy, K., The influence of gas inlet design on gas holdup values for water and various solutions in a loop-type airlift fermenter, J. Chem. Technol. Biotechnol., 34B, 151-164 (1984).