Difluoromethylornithine-induced reversible hearing loss across a wide frequency range

Laryngoscope

Volumn 114, Issue 6, 2004, Pages 1113-1117

  Smith, Mark Christopher ^a   Tinling, Steve ^a   Doyle, Karen Jo ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EFLORNITHINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUDITORY THRESHOLD; CLICK; COCHLEA; CONTROLLED STUDY; DISEASE MODEL; DOSE RESPONSE; EVOKED BRAIN STEM AUDITORY RESPONSE; GERBIL; HEARING LOSS; HISTOLOGY; MICROSCOPY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROSPECTIVE STUDY;

ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; ANTINEOPLASTIC AGENTS; AUDITORY THRESHOLD; DEAFNESS; EFLORNITHINE; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; GERBILLINAE; PROSPECTIVE STUDIES;

EID: 2942538003     PISSN: 0023852X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005537-200406000-00029     Document Type: Article

References (22)

1. Doyle KJ, McLaren CE, Shanks JE, et al. Effects of difluoromethylornithine chemoprevention on audiometry thresholds and otoacoustic emissions. Arch Otolaryngol Head Neck Surg 2001;127:553-558.
2. Meyskens FL, Gerner EW, Emerson S, et al. A randomized double-blind placebo controlled phase IIb trial of difluoromethylornithine for colon cancer prevention. J Natl Cancer Inst 1998;90:1212-1218.
3. Meyskens FL, Gerner EW. Development of difluromethylornithine (DFMO) as a chemoprevention agent. Clin Cancer Res 1999;5:945-951.
4. Doyle KJ. Delayed, reversible HL caused by difluoromethylornithine (DFMO). Laryngoscope 2001;111:781-785.
5. Henley CM, Rybak LP. Ototoxicity in developing mammals. Brain Res Rev 1995;20:68-90.
6. Jansen C, Mattox DE, Miller KD, et al. An animal model of HL from α-difluromethylornithine. Arch Otolaryngol Head Neck Surg 1989;115:1234-1237.
7. McWilliams ML, Chen GD, Fechter LD. Characterization of the ototoxicity of difluromethylornithine and its enantiomers. Toxilogic Sci 2000;56:124-132.
8. Pasic TR, Heisey D, Love RR. Alpha-difluoromethylornithine ototoxicity. Arch Otolaryngol Head Neck Surg 1997;123:1281-1286.
9. Salzer SJ, Mattox DE, Brownell WE. Cochlear damage and increased threshold in α-difluoromethylornithine (DFMO) treated guinea pigs. Hear Res 1990;46:101-112.
10. Russell DH. Ornithine decarboxylase: a key regulatory enzyme in normal and neoplastic growth. Drug Metab Rev 1985;16:1-88.
11. Slotkin TA, Bartolome J. Role of ornithine decarboxylase and the polyamines in nervous system development: a review. Brain Res Bull 1986;17:307-320.
12. Pegg AE, Shantz LM, Coleman CS. Ornithine decarboxylase as a target for chemoprevention. J Cellular Biochem 1995; supp22:132-138.
13. Henley CM, Salzer TA, Coker NJ, et al. Localization of ornithine decarboxylase (ODC) in the cochlea of the immature rat. Hear Res 1995;84:99-111.
14. Henley CM. Postnatal developmental changes in inner ear ornithine decarboxylase (ODC). Hear Res 1991;55:45-49.
15. Henley CM, Gerhardt HJ, Schacht J. Inhibition of inner ear ornithine decarboxylase by neomycin in-vitro. Brain Res Bull 1987;19:695-698.
16. Marks MC, Mattox DE, Casero RA. The effects of DFMO on polyamine metabolism in the inner ear. Hear Res 1991;53:230-236.
17. Schweitzer L, Casseday JH, Sjoerdsma A, et al. Identification of polyamines in the cochlea of the rat and their potential role in hearing. Brain Res Bull 1986;16:215-218.
18. Brock M, Henley CM. Postnatal changes in cochlear polyamine metabolism in the rat. Hear Res 1994;72:37-43.
19. Slotkin TA, Whitmore WL, Lerea L, et al. Role of ornithine decarboxylase and the polyamines in nervous system development: short-term postnatal administration of α-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase. Int J Dev Neurosci 1983;1:7-16.
20. Williams K, Romano C, Dichter M, et al. Modulation of the NMDA receptor by polyamines. Life Sci 1991;48:469-498.
21. McFadden SL, Walsh EJ, McGee J. Onset and development of auditory brainstem responses in the Mongolian gerbil (Meriones unguiculatus). Hear Res 1996;100:68-79.
22. Phillips S, Jimenez R, Pongstapron K, et al. Electron microscopic findings in cochlear hair cells of difluoromethylornithine (DFMO) treated guinea pigs. Assoc Res Otolaryngol Abstr 1992:331.