A re-examination of the circular dichroism of the calicheamicin enediyne/dienone chromophoric interaction

Organic Letters

Volumn 6, Issue 11, 2004, Pages 1801-1804

  Ding, Weidong ^a   Pitts, Keith ^a   Ellestad, George A ^a   Krishnamurthy, Girija ^a  

^a WYETH RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKENYLDIALKYNE DERIVATIVE; ANTIBIOTIC AGENT; ANTINEOPLASTIC AGENT; BENZOIC ACID; CALICHEAMICIN DERIVATIVE; ESPERAMICIN C; SHISHIIJIMICIN A; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL INTERACTION; CIRCULAR DICHROISM; MEASUREMENT; REDUCTION; SPECTRUM; STEREOCHEMISTRY;

AMINOGLYCOSIDES; ANTINEOPLASTIC AGENTS; BENZOATES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCULAR DICHROISM; ENEDIYNES; MOLECULAR STRUCTURE; POLYETHYLENE GLYCOLS; SPECTROPHOTOMETRY;

EID: 2942534853     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol0494919     Document Type: Article

References (17)

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11. II was quantified by comparing the 320 nm UV absorption peak area of II with that of standard calicheamicin on HPLC because they both have the same dienone chromophore.
12. 2O/0.1% TFA. The UV spectrum of calicheamicin was normalized with II at 320 nm. UV spectra in Figure 3b were normalized at 220 nm.
13. + for V).
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