Chromatographic determination of thiols after pre-column derivatization with o-phthalaldehyde and isoleucine

Journal of Liquid Chromatography and Related Technologies

Volumn 27, Issue 10, 2004, Pages 1593-1609

  Concha Herrera, V ^a   Torres Lapasio J R ^a   Garcia Alvarez Coque M C ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Isoindole formation; o Phthalaldehyde; Reversed phase liquid chromatography; Thiols

Indexed keywords

ALCOHOLS; ASSAYS; PH EFFECTS; SPECTROPHOTOMETRY;

MOBILE PHASES; THIOLS;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

3 MERCAPTOPROPIONIC ACID; ACETONITRILE; ACETYLCYSTEINE; CAPTOPRIL; CYSTEINE; GLUTATHIONE; ISOINDOLE DERIVATIVE; ISOLEUCINE; MERCAPTAMINE; N ACETYLPENICILLAMINE; PENICILLAMINE; PHTHALALDEHYDE; THIOGLYCOLIC ACID; THIOL DERIVATIVE; TIOPRONIN; WATER;

ARTICLE; CHEMICAL REACTION; CHROMATOGRAPHY; DRUG FORMULATION; MOLECULAR WEIGHT; PH; REACTION ANALYSIS; REVERSED PHASE LIQUID CHROMATOGRAPHY; SEPARATION TECHNIQUE; SPECTROPHOTOMETRY;

EID: 2942534138     PISSN: 10826076     EISSN: None     Source Type: Journal    
DOI: 10.1081/JLC-120034094     Document Type: Article

References (15)

1. Shimada, K.; Mitamura, K. Derivatization of thiol-containing compounds. J. Chromatogr. B 1994, 659, 227-241.
2. Goto, J. In Detection-Oriented Derivatization Techniques in Liquid Chromatography; Lingman, H., Underberg, W.J.M., Eds.; Marcel Dekker, Inc.: New York, NY, 1990; 323-358.
3. Mopper, K.; Delmas, D. Trace determination of biological thiols by liquid chromatography and pre-column fluorimetric labelling with phthalaldehyde. Anal. Chem. 1984, 56, 2557-2560.
4. Nakamura, H.; Tamura, Z. Fluorimetric determination of [biogenic] thiols by liquid chromatography with post-column derivatization. Anal. Chem. 1981, 53, 2190-2193.
5. Nakamura, H.; Tamura, Z. Simultaneous determination of biogenic thiols and disulphides by HPLC with fluorescence detection. Bunseki Kagaku 1988, 37, 35-40.
6. García-Alvarez-Coque, M.C.; Medina-Hernández, M.J.; Villanueva-Camañas, R.M.; Mongay Fernández, C. Formation and instability of o-phthalaldehyde derivatives of amino acids. A review. Anal. Biochem. 1989, 178, 1-7.
7. García-Alvarez-Coque, M.C.; Medina-Hernández, M.J.; Villanueva-Camañas, R.M.; Mongay Fernández, C. Studies on the formation and stability of isoindoles derived from amino acids, o-phthalaldehyde and N-acetyl-L-cysteine. Anal. Biochem. 1989, 180, 172-176.
8. Molnár Perl, I.; Bozor, I. Comparison of the stability and UV and fluorescence characteristics of the o-phthaldialdehyde/3-mercaptopropionic acid and o-phthaldialdehyde/N-acetyl-L-cysteine reagents and those of their amino-acid derivatives. J. Chromatogr. A 1998, 798, 37-46.
9. García-Alvarez-Coque, M.C.; Medina-Hernández, M.J.; Villanueva-Camañas, R.M.; Mongay Fernández, C. Spectrophotometric determination of N-acetylcysteine in drug formulations with o-phthalaldehyde and isoleucine. Analyst 1989, 114, 975-977.
10. Medina-Hernández, M.J.; García-Alvarez-Coque, M.C.; Bonet Domingo, E.; Villanueva-Camañas, R.M. FIA-spectrophotometric assay of N-acetylcysteine by o-phthalaldehyde derivatization. Pharmazie 1990, 45, 745-747.
11. Nakamura, H.; Matsumoto, A.; Tamura, Z. Stability of isoindole-type fluorophores derived from phthalaldehyde, primary amino-compounds and thiols. Anal. Lett. 1982, 15, 1393-1410.
12. Kutlan, D.; Presits, P.; Molnár-Perl, I. Behaviour and characteristics of amine derivatives obtained with o-phthaldialdehyde/3-mercaptopropionic acid and with o-phthaldialdehyde/N-acetyl-L-reagents. Review. J. Chromatogr. A 2002, 949, 235-248.
13. Ito, S.; Ota, A.; Yamamoto, K.; Kawashima, Y. Resolution of the enantiomers of thiol compounds by reversed-phase liquid chromatography using chiral derivatization with 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl isothiocyanate. J. Chromatogr. 1992, 626, 187-196.
14. Celma, C.; Allué, J.A.; Pruñonosa, J.; Peraire, C.; Obach, R. Determination of N-acetylcysteine in human plasma by liquid chromatography coupled to tandem mass spectrometry. J. Chromatogr. A 2000, 870, 13-22.
15. Ercal, N.; Oztezcan, S.; Hammond, T.C.; Matthews, R.H.; Spitz, D.R. High-performance liquid chromatography assay for N-acetylcysteine in biological samples following derivatization with N-(1-pyrenyl)-maleimide. J. Chromatogr. A 1996, 685, 329-334.