Thioridazine treatment prevents cardiopathy in Trypanosoma cruzi infected mice

International Journal of Antimicrobial Agents

Volumn 23, Issue 6, 2004, Pages 634-636

  Lo Presti, M S ^a   Rivarola, H W ^a   Bustamante, J M ^a   Fernandez A R ^a,b   Enders, J E ^a   Fretes, R ^a   Gea, S ^c   Paglini Oliva, P A ^a,d  

^a FACULTAD DE CIENCIAS MÉDICAS   (Argentina)

^b Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

^c UNIVERSIDAD NACIONAL DE CÓRDOBA   (Argentina)

^d NONE   (Argentina)

Author keywords

Chagas disease treatment; Thioridazine; Trypanosoma cruzi strains; Trypanotione reductase

Indexed keywords

THIORIDAZINE;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DENSITY; ELECTROCARDIOGRAPHY; FUNGAL STRAIN; FUNGUS ISOLATION; HEART DISEASE; HISTOLOGY; HUMAN; MOUSE; MYCOSIS; NONHUMAN; PARASITEMIA; PRIORITY JOURNAL; SEROLOGY; SURVIVAL RATE; TRYPANOSOMA CRUZI;

EID: 2942519720     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2003.10.006     Document Type: Article

References (12)

1. Castro C.R., Mecca M.M., Fanelli S.L., Ferreyra E.C., Díaz E.G., Castro J.A. Benznidazole-induced ultrastructural and biochemical alterations in rat oesophagus. Toxicology. 191:2003;189-198
2. Murta S.M.F., Gazzinelli R.T., Brener Z., Romanha A.J. Molecular characterization of susceptible and naturally resistant strains of Trypanosoma cruzi to Benznidazole and Nifurtimox. Mol. Biochem. Parasitol. 93:1998;203-214
3. Engels J.C., McKerrow J.H. Physiological and ultrastructural changes induced by cistein proteinase inhibitors in Trypanosoma cruzi. Mem. Inst. Oswaldo. Cruz. 90:1995;43-44
4. Gutierrez-Correa J., Fairlamb A.H., Stoppani O.M. Trypanosoma cruzi trypanothione reductase is inactivated by peroxidase - generated phenotiazine cation radicals. Free Rad. Res. 34:2001;363-378
5. Bondy B. Resents trends in the field of calmodulin inhibitors. Biol. Chem. Aspects Thiazines Analogs. 1:1995;433-434
6. Paglini-Oliva P., Fernández A.R., Fretes R., Pelsman A. Structural, ultrastuctural studies and evolution of Trypanosoma cruzi infected mice treated with thioridazine. Exp. Mol. Pathol. 65:1998;78-86
7. Luquetti A., Prata A., Moncayo A., Romaha A., Lingales B., et al. Recommendations from a Satellite Meeting. International Symposium to commemorate the 90th anniversary of the discovery of Chagas' disease. Mem Inst Oswaldo Cruz. 94:1999;429-432
8. Rivarola W., Fernández A.R., Enders J.E., Gea S., Palma J.A., Paglini-Oliva P. Thioridazine treatment modifies the evolution of Trypanosoma cruzi infection in mice. Ann. Trop. Med. Parasitol. 93:1999;695-702
9. Montamat E.E., Doro G.M.D., Gallerano R.H., Sosa R., Blanco A. Characterization of Trypanosoma cruzi population by zymodemes: correlation with clinical picture. Am. J. Trop. Med. Hyg. 55:1996;625-628
10. Guide for the Care and Use of Laboratory Animals. Bethesda (MD, USA): Office of Science and Health Report, DRR/NIH, 1985 [DHEW publication no. (NIH) 85-23].
11. Gea S., Rodriguez P., Vottero-Cima E. Characterization of T cruzi antigens recognized by sera from patients with chronic Chagas' disease. Int. Arch. Allergy Appl. Immunol. 84:1987;410-413
12. Segura M.A., Barberá L.C., Ramos F., Basombrio M.A. Regression of antibodies and resistance to reinfection in mice inoculated with an attenuated Trypanosoma cruzi strain and treated with Nifurtimox. Mem. Inst. Oswaldo. Cruz. 91:1996;316