Positive interactive radiosensitisation in vitro with the combination of two nucleoside analogues, (E)-2′-deoxy-2′-(fluoromethylene) cytidine and iododeoxyuridine

European Journal of Cancer

Volumn 40, Issue 10, 2004, Pages 1572-1580

  Coucke, Philippe A ^a   Cottin, E ^a   Azria, David ^b   Martineau, Pierre ^c   Adamer, Florence ^a   Decosterd, Laurent A ^a   Buchegger, Franz ^a   Do, Huu Phuoc ^a  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^b INSERM   (France)

^c CNRS   (France)

Author keywords

(E) 2 Deoxy 2 (fluoromethylene) cytidine; Iododeoxyuridine; Radiosensitisers

Indexed keywords

IDOXURIDINE; TEZACITABINE;

ARTICLE; DRUG POTENCY; DRUG POTENTIATION; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; RADIOSENSITIZATION;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CELL LINE, TUMOR; COLONIC NEOPLASMS; DEOXYCYTIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; HUMANS; IDOXURIDINE; RADIATION-SENSITIZING AGENTS;

EID: 2942516231     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2004.01.040     Document Type: Article

References (34)

1. Gregoire V., Hittelman W.N. Nucleoside analogs as radiosensitizing agents. Cheson B.D., Keating M.J., Plunkett W. Nucleoside analogs in cancer therapy. 1997;315-358 Marcel Dekker, New York
2. ′ -deoxy-(fluoromethylene)cytidine as a cytotoxic radiosensitizer in vitro Cancer Res. 59:1999;5219-5226
3. Decosterd L.A., Cottin E., Chen X., Lejeune F., Mirimanoff R.O., Biollaz J., et al. Simultaneous determination of deoxyribonucleoside in the presence of ribonucleoside triphosphates in human carcinoma cells by high-performance liquid chromatography. Anal. Biochem. 270:1999;59-68
4. ′ deoxyuridine J. Nucl. Biol. Med. 35(3):1991;167-173
5. Breitman T.R. The feedback inhibition of thymidine kinase. Biochim. Biophys. Acta. 67:1963;153-158
6. ′ -aminothymidine in human bladder cancer cells in vitro Cancer Res. 46:1986;4522-4526
7. Weber G. Biochemical strategy of cancer cells and the design of chemotherapy. G.H.A. Clowes Memorial Lecture. Cancer Res. 43:1983;3466-3492
8. Steel G.G., Peckham M.J. Exploitable mechanisms in combined radiotherapy-chemotherapy: the concept of additivity. Int. J. Radiat. Oncol. Biol. Phys. 5:1979;85-91
9. Steel G.G. Terminology in the description of drug-radiation interactions. Int. J. Radiat. Oncol. Biol. Phys. 5:1979;1145-1150
10. Kano Y., Ohnuma T., Okano T. Effects of vincristine in combination with methotrexate and other antitumor agents in human acute lymphoblastic leukemia cells in culture. Cancer Res. 48:1988;351-356
11. 125I-iododeoxyuridine in 2 human glioblastoma cell lines. Nucl. Med. Commun. 21:2000;947-953
12. 125I]iododeoxyuridine in human xenografted glioblastomas. Eur. J. Nucl. Med. 29:2002;499-505
13. Phillips T.L., Bodell W.J., Uhl V., Ross G.Y., Rasmussen J., Mitchell J.B. Correlation of exposure time, concentration and incorporation of IdUrd in V-79 cells with radiation response. Int. J. Radiat. Oncol. Biol. Phys. 16:1989;1251-1255
14. Schultz C., Gaffney D., Lindstrom M.J., Kinsella T.J. Iododeoxyuridine radiosensitization of human glioblastoma cells exposed to acute and chronic gamma irradiation; mechanistic implications and clinical relevance. Cancer J. Sci. Am. 1:1995;151-161
15. Kuo M.L., Kinsella T.J. Expression of ribonucleotide reductase after ionizing irradiation in human cervical carcinoma cells. Cancer Res. 58:1998;2245-2252
16. Friedberg E.C., Walker G.C., Siede W. DNA repair and mutagenesis. 1995;American Society for Microbiology, Washington, DC. p. 6-14
17. Reichard P. Interactions between deoxyribonucleotide and DNA synthesis. Annu. Rev. Biochem. 57:1988;349-374
18. ′ -deoxy-(fluoromethylene) cytidine, a novel inhibitor of ribonucleoside diphosphate reductase, on human colon carcinoma xenografts in nude mice Cancer Res. 57:1997;4023-4028
19. ′ -deoxy-(fluoromethylene)cytidine potentiates radioresponse of two human solid tumor xenografts Cancer Res. 58:1998;5411-5417
20. ′ -deoxyuridine radiosensitization in U251 human glioblastoma xenografts Clin. Canc. Res. 6:2000;1468-1475
21. ′ -deoxyribose as a radiosensitizing prodrug in two, non-rodent animal species. Implications for phase I study design Clin. Canc. Res. 6:2000;3670-3679
22. Herman J., Umar A., Polyak K., Graff J., Ahuja N., Markowitz S., et al. Incidence and functional consequences of hMLH1 promoter hypermerthylation in colorectal carcinoma. Proc. Natl. Acad. Sci. USA. 95:1998;6870-6875
23. Schultz C., Gaffney D., Lindstrom M.J., Kinsella T.J. Iododeoxyuridine radiosensitization of human glioblastoma cells exposed to acute and chronic gamma irradiation: mechanistic implications and clinical relevance. Cancer J. Sci. Am. 1:1995;151-161
24. Fink D., Aebi S., Howell S. The role of DNA mismatch repair in drug resistance. Clin. Cancer Res. 4:1998;1-6
25. Lage H., Dietel M. Involvement of the DNA mismatch repair system in antineoplastic drug resistance. J. Cancer Res. Clin. Oncol. 125:1999;156-165
26. Berry S.E., Davis T.W., Schupp J.E., Hwang H-S., de Wind N., Kinsella T.J. Selective radiosensitization of drug-resistant MutS homologue-2 (MSH2) mismatch repair deficient cells by halogenated thymidine (dThd) analogues: MSH2 mediated dThd analogue DNA levels and the differential cytotoxicity and cell cycle effects of the dThd analogues and 6-thioguanine. Cancer Res. 60:2000;5773-5780
27. Uhl V., Phillips T.L., Ross G.Y., Bodell W.J., Rasmussen J. Iododeoxyuridine incorporation and radiosensitization in three human tumor cell lines. Int. J. Radiat. Oncol. Biol. Phys. 22:1992;489-494
28. Lawrence T.S., Davis M.A., Maybaum J., Stetson P.L., Ensminger W.D. Modulation of iododeoxyuridine-mediated radiosensitization by 5-fluorouracil in human colon cancer cells. Int. J. Radiat. Oncol. Biol. Phys. 22:1992;499-503
29. ′ -aminothymidine and leucovorin on radiosensitisation by iododeoxuridine in human colon cancer cells Clin. Cancer Res. 1:1995;407-416
30. ′ -deoxythymidine in normal mouse tissues and two human colon cancer xenografts Clin. Cancer Res. 2:1996;981-989
31. ′ -deoxy-(fluoromethylene)cytidine by pentoxifylline in vitro Int. J. Cancer. 80:1999;155-160
32. Coucke PA, Cottin E, Decosterd LA, Azria D, Martineau P, Decosterd LA. Simultaneous alteration of de novo and salvage pathway to the deoxynucleoside triphosphate pool by (E)-2′-deoxy-(fluoromethylene)cytidine (FMdC) and zidovudine (AZT) results in increased radiosensitivity in vitro [in preparation]
33. McGinn C.J., Kunugi K.A., Tutsch K.D., Feieraband C., Alberti D., Lindstrom M.J., et al. Leucovorin modulation of 5-iododeoxyuridine radiosensitization: a phase I study. Clin. Cancer Res. 2:1996;1299-1305
34. ′ -triphosphate Chem. Biol. Interact. 1:1969-1970;285-299