Differences in catalytic activity between rat testicular and ovarian carbonyl reductases are due to two amino acids

FEBS Letters

Volumn 580, Issue 1, 2006, Pages 67-71

  Sciotti, Michel A ^a   Tam, Steven ^b   Wermuth, Bendicht ^a   Baker, Michael E ^b  

^a Institute of Clinical Chemistry   (Switzerland)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Carbonyl reductase; Enzyme evolution; Xenobiotics

Indexed keywords

AMINO ACID; CARBONYL REDUCTASE; MENADIONE; PYRIDINE DERIVATIVE;

AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; CATALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; MALE; MOLECULAR MODEL; NONHUMAN; OVARY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STABILITY; SEQUENCE HOMOLOGY; TESTIS;

ALCOHOL OXIDOREDUCTASES; AMINO ACIDS; ANIMALS; CATALYSIS; FEMALE; ISOENZYMES; MALE; ORGAN SPECIFICITY; OVARY; PROTEIN STRUCTURE, TERTIARY; PYRIDINES; RATS; STRUCTURAL HOMOLOGY, PROTEIN; TESTIS; VITAMIN K 3;

ANIMALIA;

EID: 29344462467     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2005.11.049     Document Type: Article

References (20)

1. B. Wermuth Purification and properties of an NADPH-dependent carbonyl reductase from human brain: relationship to prostaglandin 9-keto reductase and xenobiotic ketone reductase J. Biol. Chem. 256 1981 1206 1213
2. B. Wermuth, K.M. Bohren, G. Heinemann, J.P. von Wartburg, and K.H. Gabbay Human carbonyl reductase: nucleotide sequence analysis and amino acid sequence of the encoded protein J. Biol. Chem. 263 1988 16185 16188
3. K. Watanabe, C. Sugawara, A. Ono, Y. Fukuzumi, S. Itakura, M. Yamazaki, H. Tashiro, K. Osoegawa, E. Soeda, and T. Nomura Mapping of a novel human carbonyl reductase, CBR3, and ribosomal pseudogenes to human chromosome 21q22.2 Genomics 52 1998 95 100
4. B. Wermuth, K. Bohren, and E. Ernst Autocatalytic modification of human carbonyl reductase by 2-oxocarboxylic acids FEBS Lett. 335 1993 151 154
5. H. Aoki, T. Okada, T. Mizutani, Y. Numata, T. Minegishi, and K. Miyamoto Identification of two closely related genes, inducible and noninducible carbonyl reductases in the rat ovary Biochem. Biophys. Res. Commun. 230 1997 518 523
6. H. Jornvall, B. Persson, M. Krook, S. Atrian, R. Gonzalez-Duarte, J. Jeffrey, and D. Ghosh Short-chain dehydrogenases/reductases (SDR) Biochemistry 34 1995 6003 6013
7. M.E. Baker Evolution of 17beta-hydroxysteroid dehydrogenases and their role in androgen, estrogen and retinoid action Mol. Cell. Endocrinol. 171 2001 211 215
8. B. Wermuth, G. Mäder-Heineman, and E. Ernst Cloning and expression of carbonyl reductase from rat testis Eur. J. Biochem. 228 1995 473 479
9. N. Tanaka, T. Nonaka, T. Tanabe, T. Yoshimoto, D. Tsuru, and Y. Mitsui Crystal structures of the binary and ternary complexes of 7α- hydroxysteroid dehydrogenase from Escherichia coli Biochemistry 35 1996 7715 7730
10. +-dependent prostaglandin dehydrogenase Proc. Natl. Acad. Sci. USA 90 1993 502 506
11. M.A. Sciotti, S. Nakajin, B. Wermuth, and M.E. Baker Mutation of threonine-241 to proline eliminates autocatalytic modification of human carbonyl reductase Biochem. J. 350 2000 89 92
12. R. Higuchi, B. Krummel, and R.K. Saiki A general method of in vitro preparation and specific mutagenesis of DNA fragments: study of protein and DNA interactions Nucleic Acids Res. 16 1988 7351 7367
13. 4 Nature 27 1970 680 685
14. D. Ghosh, M. Sawicki, V. Pletnev, M. Erman, S. Ohno, S. Nakajin, and W.L. Duax Porcine carbonyl reductase. structural basis for a functional monomer in short chain dehydrogenases/reductases J. Biol. Chem. 276 2001 18457 18463
15. Homology, User Manual, Accelrys Inc. San Diego, 1998.
16. S. Nakajin, N. Takase, S. Ohno, S. Toyoshima, and M.E. Baker Mutation of tyrosine-194 and lysine-198 in the catalytic site of pig 3α/β, 20β-hydroxysteroid dehydrogenase Biochem. J. 334 1998 553 557
17. + and pseudotropine at 1.9 AA resolution: implication for sterospecific substrate binding and catalysis Biochemistry 38 1999 7630 7637
18. J. Benach, S. Atrian, R. Gonzalez-Duarte, and R. Ladenstein The refined crystal structure of Drosophila lebanonensis alcohol dehydrogenase at 1.9 Å resolution J. Mol. Biol. 282 1998 383 399
19. + identifies two principal targets for the design of inhibitors Structure 4 1996 905 915
20. + Proc. Natl. Acad. Sci. USA 96 1999 840 845