Expression of cochlin in the vestibular organ of rats

ORL

Volumn 67, Issue 5, 2005, Pages 252-258

  Ikezono, Tetsuo ^a   Shindo, Susumu ^a   Ishizaki, Masamichi ^a   Li, Lishu ^a   Tomiyama, Shunichi ^a   Takumida, Masaya ^b   Pawankar, Ruby ^a   Watanabe, Atsushi ^a   Saito, Akihiko ^a   Yagi, Toshiaki ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

Author keywords

COCH gene; Cochlin; DFNA9; Hereditary hearing impairment; Immunohistochemistry; Inner ear; Vestibular organ of rats

Indexed keywords

COCHLIN; ISOPROTEIN; PROTEIN; PROTEIN ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIBODY LABELING; ANTIBODY SPECIFICITY; ARTICLE; CONTROLLED STUDY; DENDRITE; INNER EAR; INNERVATION; NONHUMAN; OTOLITH; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; SEMICIRCULAR CANAL; SENSORY NERVE CELL; TISSUE DISTRIBUTION; VESTIBULAR LABYRINTH; VESTIBULAR SYSTEM; VESTIBULE;

ANIMALS; DEAFNESS; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; MENIERE'S DISEASE; MUTATION; PROTEIN ISOFORMS; PROTEINS; RATS; VESTIBULE;

EID: 29344461480     PISSN: 03011569     EISSN: None     Source Type: Journal    
DOI: 10.1159/000089404     Document Type: Article

References (26)

1. Robertson NG, Lu L, Heller S, Merchant SN, Eavey RD, McKenna M, Nadol JB Jr, Miyamoto RT, Linthicum FH Jr, Lubianca Neto JF, Hudspeth AJ, Seidman CE, Morton CC, Seidman JG: Mutations in a novel cochlear gene cause DFNA9, a human nonsyndromic sensorineural deafness with vestibular dysfunction. Nat Genet 1998;20:299-303.
2. Ikezono T, Omori A, Ichinose S, Pawankar R, Watanabe A, Yagi T: Identification of the protein product of the Coch gene (hereditary deafness gene) as the major component of bovine inner ear protein. Biochim Biophys Acta 2001;1535:258-265.
3. Van Camp G, Smith RJH: Hereditary Hearing Loss Home Page. http://dnalab-www.uia.ac.be/dnalab/hhh.
4. Verhagen WI, Huygen PL, Joosten EM: Familial progressive vestibulocochlear dysfunction. Arch Neurol 1988;45:766-768.
5. Khetarpal U, Schuknecht HF, Gacek RR, Holmes LB: Autosomal dominant sensorineural hearing loss: pedigrees, audiologic findings, and temporal bone findings in two kindreds. Arch Otolaryngol Head Neck Surg 1991;117:1032-1042.
6. Verhagen WI, Huygen PL, Bles W: A new autosomal dominant syndrome of idiopathic progressive vestibulo-cochlear dysfunction with middle-age onset. Acta Otolaryngol 1992;112:899-906.
7. Manolis EN, Yandavi N, Nadol JB Jr, Eavey RD, McKenna M, Rosenbaum S, Khetarpal U, Halpin C, Merchant SN, Duyk GM, MacRae C, Seidman CE, Seidman JG: A gene for nonsyndromic autosomal dominant progressive postlingual sensorineural hearing loss maps to chromosome 14q12-13. Hum Mol Genet 1996;5:1047-1050.
8. de Kok YJ, Bom SJ, Brunt TM, Kemperman MH, van Beusekom E, van der Velde-Visser SD, Robertson NG, Morton CC, Huygen PL, Verhagen WI, Brunner HG, Cremers CW, Cremers FP: A Pro51Ser mutation in the COCH gene is associated with late onset autosomal dominant progressive sensorineural hearing loss with vestibular defects. Hum Mol Genet 1999;8:361-366.
9. Bom SJ, Kemperman MH, De Kok YJ, Huygen PL, Verhagen WI, Cremers FP, Cremers CW: Progressive cochleovestibular impairment caused by a point mutation in the COCH gene at DFNA9. Laryngoscope 1999;109:1525-1530.
10. Fransen E, Verstreken M, Verhagen WI, Wuyts FL, Huygen PL, D'Haese P, Robertson NG, Morion CC, McGuirt WT, Smith RJ, Declau F, Van de Heyning PH, Van Camp G: High prevalence of symptoms of Meniere's disease in three families with a mutation in the COCH gene. Hum Mol Genet 1999;8:1425-1429.
11. Ikezono T, Shindo S, Li L, Omori A, Ichinose S, Watanabe A, Kobayashi T, Pawankar R, Yagi T: Identification of a novel Cochlin isoform in the perilymph: insights to Cochlin function and the pathogenesis of DFNA9. Biochem Biophys Res Commun 2004;314:440-446.
12. Solares CA, Edling AE, Johnson JM, Baek MJ, Hirose K, Hughes GB, Tuohy VK: Murine autoimmune hearing loss mediated by CD4+ T cells specific for inner ear peptides. J Clin Invest 2004;113:1210-1217.
13. Li L, Ikezono T, Watanabe A, Shindo S, Pawankar R, Yagi T: Expression of full-length Cochlin p63s is inner ear specific. Auris Nasus Larynx 2005;32:219-223.
14. Khetarpal U: Autosomal dominant sensorineural hearing loss: further temporal bone findings. Arch Otolaryngol Head Neck Surg 1993;119:106-108.
15. Robertson NG, Resendes BL, Lin JS, Lee C, Aster JC, Adams JC, Morton CC: Inner ear localization of mRNA and protein products of COCH, mutated in the sensorineural deafness and vestibular disorder, DFNA9. Hum Mol Genet 2001;10:2493-2500.
16. Merchant SN, Linthicum FH, Nadol JB Jr: Histopathology of the inner ear in DFNA9. Adv Otorhinolaryngol 2000;56:212-217.
17. Khetarpal U, Robertson NG, Yoo TJ, Morton CC: Expression and localization of COL2A1 mRNA and type II collagen in human fetal cochlea. Hear Res 1994;79:59-73.
18. Tsuprun V, Santi P: Ultrastructure and immunohistochemical identification of the extracellular matrix of the chinchilla cochlea. Hear Res 1999;129:35-49.
19. Goodyear RJ, Richardson GP: Extracellular matrices associated with the apical surfaces of sensory epithelia in the inner ear: molecular and structural diversity. J Neurobiol 2002;53:212-227.
20. Colombatti A, Bonaldo P: The superfamily of proteins with von Willebrand factor type A-like domains: one theme common to components of extracellular matrix, hemostasis, cellular adhesion, and defense mechanisms. Blood 1991;77:2305-2315.
21. Khetarpal U: DFNA9 is a progressive audiovestibular dysfunction with a microfibrillar deposit in the inner ear. Laryngoscope 2000;110:1379-1384.
22. Committee on Hearing and Equilibrium: Meniere's disease: criteria for diagnosis and evaluation of therapy for reporting. Otolaryngol Head Neck Surg 1995;113:181-185
23. Kemperman MH, Bom SJ, Lemaire FX, Verhagen WI, Huygen PL, Cremers CW: DFNA9/COCH and its phenotype. Adv Otorhinolaryngol 2002;61:66-72.
24. Sanchez E, Lopez-Escamez JA, Lopez-Nevot MA, Lopez-Nevot A, Cortes R, Martin J: Absence of COCH mutations in patients with Meniere disease. Eur J Hum Genet 2004;12:75-78.
25. Cohen-Salmon M, El-Amraoui A, Leibovici M, Petit C: Otogelin: a glycoprotein specific to the acellular membranes of the inner ear. Proc Natl Acad Sci USA 1997;94:14450-14455.
26. Killick R, Malenczak C, Richardson GP: The protein composition of the avian tectorial membrane. Hear Res 1992;64:21-38.