Blockade of muscarinic acetylcholine receptors in the ventral tegmental area disrupts food-related learning in rats

Psychopharmacology

Volumn 184, Issue 1, 2006, Pages 87-94

  Sharf, Ruth ^a   Ranaldi, Robert ^a  

^a CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

Acetylcholine; Classical conditioning; Feeding; Muscarinic; Operant conditioning; Ventral tegmental area

Indexed keywords

MUSCARINIC RECEPTOR; SCOPOLAMINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONDITIONING; CONTROLLED STUDY; EATING; FOOD INTAKE; LEARNING; MALE; MICROINJECTION; NONHUMAN; PRIORITY JOURNAL; RAT; VENTRAL TEGMENTUM;

ANIMALS; CONDITIONING (PSYCHOLOGY); CONDITIONING, CLASSICAL; CONDITIONING, OPERANT; EATING; FEEDING BEHAVIOR; MALE; MUSCARINIC ANTAGONISTS; RATS; RATS, LONG-EVANS; RECEPTORS, MUSCARINIC; REINFORCEMENT SCHEDULE; REWARD; SCOPOLAMINE; VENTRAL TEGMENTAL AREA;

EID: 29344452155     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-005-0235-9     Document Type: Article

References (14)

1. Ikemoto S, Panksepp J (1996) Dissociations between appetitive and consummatory responses by pharmacological manipulations of reward-relevant brain regions. Behav Neurosci 110:331-345
2. Knott PD, Clayton KN (1966) Durable secondary reinforcement using brain stimulation as the primary reinforcer. J Comp Physiol Psychol 61:151-153
3. Kofman O, Yeomans JS (1988) Cholinergic antagonists in ventral tegmentum elevate thresholds for lateral hypothalamic and brainstem self-stimulation. Pharmacol Biochem Behav 31:547-559
4. Lubow RE, Moore AU (1959) Latent inhibition: the effect of nonreinforced preexposure to the conditional stimulus. J Comp Physiol Psychol 52:415-419
5. Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates, 2nd edn. Academic, New York
6. Pratt WE, Kelley AE (2004) Nucleus accumbens acetylcholine regulates appetitive learning and motivation for food via activation of muscarinic receptors. Behav Neurosci 118:730-739
7. Rada PV, Mark GP, Yeomans JS, Hoebel BG (2000) Acetylcholine release in ventral tegmental area by hypothalamic self-stimulation, eating, and drinking. Pharmacol Biochem Behav 65:375-379
8. Redgrave P, Horrell RI (1976) Potentiation of central reward by localised perfusion of acetylcholine and 5-hydroxytryptamine. Nature 262:305-307
9. See RE, McLaughlin J, Fuchs RA (2003) Muscarinic receptor antagonism in the basolateral amygdala blocks acquisition of cocaine-stimulus association in a model of relapse to cocaine-seeking behavior in rats. Neuroscience 117:477-483
10. Winer BJ (1971) Statistical principles in experimental design, 2nd edn. McGraw-Hill, New York
11. Wise RA, Hoffman DC (1992) Localization of drug reward mechanisms by intracranial injections. Synapse 10:247-263
12. Yeomans J, Baptista M (1997) Both nicotinic and muscarinic receptors in ventral tegmental area contribute to brain-stimulation reward. Pharmacol Biochem Behav 57(4):915-921
13. Yeomans JS, Kofman O, McFarlane V (1985) Cholinergic involvement in lateral hypothalamic rewarding brain stimulation. Brain Res 329:19-26
14. Yeomans JS, Mathur A, Tampakeras M (1993) Rewarding brain stimulation: role of tegmental cholinergic neurons that activate dopamine neurons. Behav Neurosci 107:1077