A new method for drug application to the inner ear

ORL

Volumn 67, Issue 5, 2005, Pages 272-275

  Ito, Juichi ^a   Endo, Tsuyoshi ^a   Nakagawa, Takayuki ^a   Kita, Tomoko ^a   Kim, Tae Soo ^a   Iguchi, Fukuichiro ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Biodegradable hydrogel; Drug delivery system; Hair cell; Regeneration; Spiral ganglion neuron

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; DRUG CARRIER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIODEGRADABILITY; CELL SURVIVAL; COCHLEA FENESTRA; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; EAR PROTECTION; GUINEA PIG; HAIR CELL; HYDROGEL; INNER EAR; INNER EAR DISEASE; METHODOLOGY; NERVE CELL; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL; SPIRAL GANGLION;

ANIMALS; BIODEGRADATION, ENVIRONMENTAL; BRAIN-DERIVED NEUROTROPHIC FACTOR; DRUG CARRIERS; EAR, INNER; ENZYME-LINKED IMMUNOSORBENT ASSAY; GUINEA PIGS; HYDROGEL; NEURONS; ROUND WINDOW; SPIRAL GANGLION;

EID: 29344443035     PISSN: 03011569     EISSN: None     Source Type: Journal    
DOI: 10.1159/000089407     Document Type: Article

References (7)

1. Shinohara T, Bredberg G, Ulfendahl M, et al: Neurotrophic factor intervention restores auditory function in deafened animals. Proc Natl Acad Sci USA 2002;99:1657-1660.
2. Iguchi F, Nakagawa T, Tateya I, et al: Trophic support of mouse inner ear by neural stem cell transplantation. Neuroreport 2003;20:77-80.
3. Juhn SK, Rybak LP: Labyrinthine barriers and cochlear homeostasis. Acta Otolaryngol 1981;91:529-534.
4. Tabata Y, Nagano A, Ikada Y: Biodegradation of hydrogel carrier incorporating fibroblast growth factor. Tissue Eng 1999;5:127-131.
5. Yamamoto M, Takahashi Y, Tabata Y: Controlled release by biodegradable hydrogels enhances the ectopic bone formation of bone morphogenetic protein. Biomaterials 2003;24:4375-4383.
6. Ylikoski J, Pirvola U, Suvanto J, et al: Guinea pig auditory neurons are protected by glial cell line-derived neurotrophic factor from degeneration after noise trauma. Hear Res 1998;124:17-26.
7. Yagi M, Magal E, Sheng Z, et al: Hair cell protection from aminoglycoside ototoxicity by adenovirus-mediated overexpression of glial cell line-derived neurotrophic factor. Hum Gene Ther 1999;10:813-823.