Highly enantioselective synthesis of γ-hydroxy-α,β- acetylenic esters by asymmetric alkyne addition to aldehydes

Angewandte Chemie - International Edition

Volumn 45, Issue 1, 2005, Pages 122-125

  Gao, Ge ^a   Wang, Qin ^a   Yu, Xiao Qi ^a   Xie, Ru Gang ^a   Pu, Lin ^b  

^a China   (China)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Aldehydes; Alkynes; Asymmetric synthesis; Binol ligands; Esters

Indexed keywords

ALDEHYDES; MOLECULAR STRUCTURE; STEREOCHEMISTRY; SYNTHESIS (CHEMICAL);

ALKYNES; ASYMMETRIC SYNTHESIS; BINOL LIGANDS;

ESTERS;

ALDEHYDE; ALKYNE; ESTER;

ACETYLATION; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; HYDROXYLATION; STEREOISOMERISM; SYNTHESIS;

ACETYLATION; ALDEHYDES; ALKYNES; ESTERS; HYDROXYLATION; MOLECULAR STRUCTURE; STEREOISOMERISM;

EID: 29344434407     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200500469     Document Type: Article

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40. Experimental details of the synthesis and characterization of the chiral γ-hydroxy-α,β-acetylenic esters and the assignment of the absolute configuration, determined by preparation of the Mosher esters, are given in the Supporting Information.