Discovery of fused azeticlines as novel selective α4β2 neuronal nicotinic receptor (NNR) agonists

Pure and Applied Chemistry

Volumn 77, Issue 12, 2005, Pages 2041-2045

  Ji, Jianguo ^a   Bunnelle, William H ^a   Li, Tao ^a   Pace, Jennifer M ^a   Schrimpf, Michael R ^a   Sippy, Kevin B ^a   Anderson, David J ^a   Meyer, Michael D ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Antinociceptive; Fused azetidines; Neuronal nicotinic receptors; NNR agonists; NNR based analgesics

Indexed keywords

EID: 29244484780     PISSN: 00334545     EISSN: None     Source Type: Journal    
DOI: 10.1351/pac200577122041     Document Type: Conference Paper

References (16)

1. M. W. Decker, M. D. Meyer, J. P. Sullivan. Expert Opin. Investig. Drugs 10, 1819 (2001).
2. L. M. Marubio, M. del Mar Arroyo-Jimenez, M. Cordero-Erausquin, C. Lena, N. Le Novere, A. de Kerchove d'Exaerde, M. Huchet, M. I. Damaj, J.-P. Changeux. Nature (London) 398, 805 (1999).
3. T. F. Spande, H. M. Garraffo, M. W. Edwards, H. J. Yeh, L. Pannell, J. W. Daly. J. Am. Chem. Soc. 114, 3475 (1992);
4. B. Badio and J. W. Daly. Mol. Pharmacol. 45, 563 (1994).
5. A. W. Bannon, M. W. Decker, M. W. Holladay, P. Curzon, D. Donnelly-Roberts, P. S. Puttfarcken, R. S. Bitner, A. Diaz, A. H. Dickenson, R. D. Porsolt, M. Williams, S. P. Arneric. Science 279, 77 (1998);
6. L. A. Sorbera, L. Revel, P. A. Leeson, J. Castaner. Drugs Future 26, 927 (2001).
7. M. R. Schrimpf, K. R. Tietje, R. B. Toupence, J. Ji, A. Basha, W. H. Bunnelle, J. F. Daanen, K. B. Sippy, J. M. Pace. WO 0181347;
8. K. K. Jain Curr. Opin. Investig. Drugs 5, 78 (2004).
9. J.-P. Jacquet, D. Bouzard, J.-R. Kiechel, P. Remuzon. Tetrahedron Lett. 32, 1565 (1991).
10. E. Jaeger and J. H. Biel. J. Org. Chem. 30, 740 (1965).
11. (a) W. Tang, S. Wu, X. Zhang. J. Am. Chem. Soc. 125, 9570 (2003);
12. (b) R. Hanselmann, J. Zhou, P. Ma, P. N. Confalone. J. Org. Chem. 68, 8739 (2003);
13. (c) N. Ohta, T. Makino, S. Shimuzu. WO 9965918.
14. H. M. I. Osborn, N. Gemmell, L. M. Harwood. J. Chem. Soc., Perkin Trans. 1 2419 (2002);
15. K. V. Gothelf and K. A. Jorgenson Chem. Rev. 98, 863 (1998).
16. A. R. Muci and S. L. Buchwald. Top. Curr. Chem. 219, 131 (2002).