Short step synthesis of an antibiotic, 6-cyano-5-methoxy-12-methylindolo[2,3-a]carbazole

Heterocycles

Volumn 64, Issue , 2004, Pages 483-489

  Somei, Masanori ^a   Yamada, Fumio ^a   Suzuki, Yoshiaki ^a   Ohmoto, Shinobu ^a   Hayashi, Hiroyuki ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 29244473327     PISSN: 03855414     EISSN: None     Source Type: Journal    
DOI: 10.3987/COM-04-S(P)29     Document Type: Article

References (20)

1. Kurauchi T., Goto A., Tanimoto A., Hayashi T., Oshikiri N., Yamada K., Yamada F., and Somei M. Abstracts, 30th Congress of Heterocyclic Chemistry. Hachioji, Japan (Nov., 1999) 370. Definition of an intellectual property factor (IPF) in synthesis: IPF is the total rate of one's own intellectual property of every compound involved in the synthesis, including starting material, target compound, and all synthetic intermediates. It is calculated by the following formula. {A formula is presented}
2. Definition of an application potential factor (APF) in synthesis: APF is the total potential of application of every compound involved in the synthesis, including starting material, target compound, and all synthetic intermediates. It is calculated by the following formula. {A formula is presented}
3. Knübel G., Larsen L.K., Moore R.E., Levine I.A., and Patterson G.M.L. J. Antibiotics 43 (1990) 1236
4. 5c,d:
5. 5c,d:
6. 5c,d:
7. 5c,d:
8. 5c,d:
9. Definition of originality rate:. Somei M., Fukui Y., Hasegawa M., Oshikiri N., and Hayashi T. Heterocycles 53 (2000) 1725
10. Somei M. Yakugaku Zasshi 108 (1988) 361
11. Somei M. J. Synth. Org. Chem. 40 (1982) 387
12. Madelung W., and Siegert P. Ber. 57 (1924) 222
13. Bergman J., and Eklund N. Chemica Scripta 19 (1982) 193
14. McGovern P.E., and Michel R.H. Acc. Chem. Res. 23 (1990) 152
15. Somei M., and Yamada F. Chem. Pharm. Bull. 32 (1984) 5064
16. Yamada F., Makita Y., Suzuki T., and Somei M. Chem. Pharm. Bull. 33 (1985) 2162
17. Review of indigo dye:. McGovern P.E., and Michel R.H. and references cited therein. Acc. Chem. Res. 23 (1990) 152
18. Ebara T., Takahashi T., and Maeda M. Abstract of Papers, No. 2, 120th Annual Meeting of Pharmaceutical Society of Japan. Gifu (March, 2000) 136. Potent biological activity of 3 and its derivatives was reported:
19. Preliminary biological results were presented partly (see reference 5a). The invention is now applying to a patent.
20. Gilmore C.J. J. Appl. Cryst. 17 (1984) 42