A randomized, double-blind, vehicle-controlled, bilateral comparison trial of bexarotene gel 1% versus vehicle gel in combination with narrowband UVB phototherapy for moderate to severe psoriasis vulgaris

Journal of the American Academy of Dermatology

Volumn 54, Issue 1, 2006, Pages 115-118

  Magliocco, Melissa Amy ^a   Pandya, Komal ^a   Dombrovskiy, Viktor ^a   Christiansen, Linda ^a   Wong, Yuk ^a   Gottlieb, Alice Bendix ^a  

^a ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BEXAROTENE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG ERUPTION; DRUG SAFETY; ERYTHEMA; FEMALE; GEL; HUMAN; MALE; PHOTOTHERAPY; PRIORITY JOURNAL; PSORIASIS; RANDOMIZED CONTROLLED TRIAL; SKIN IRRITATION; ULTRAVIOLET B RADIATION;

ADMINISTRATION, TOPICAL; ADULT; AGED; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FEMALE; GELS; HUMANS; MALE; MIDDLE AGED; PILOT PROJECTS; PSORIASIS; RETINOIDS; SEVERITY OF ILLNESS INDEX; TETRAHYDRONAPHTHALENES; TREATMENT OUTCOME; ULTRAVIOLET THERAPY;

EID: 29244467162     PISSN: 01909622     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaad.2005.09.012     Document Type: Article

References (7)

1. S.L. Gottlieb, E. Hayes, P. Gilleaudeau, I. Cardinale, A.B. Gottlieb, and J.G. Krueger Cellular actions of etretinate in psoriasis: enhanced epidermal differentiation and reduced cell-mediated inflammation are unexpected outcomes J Cutan Pathol 23 1996 404 418
2. N.J. Lowe, J.H. Prystowsky, T. Bourget, J. Edelstein, S. Nychay, and R. Armstrong Acitretin plus UVB therapy for psoriasis: comparisons with placebo plus UVB and acitretin alone J Am Acad Dermatol 24 1991 591
3. P.I. Spuls, M. Rozenblit, and M. Lebwohl Retrospective study of the efficacy of narrowband UVB and acitretin J Dermatol Treat 14 2003 17 20
4. C.E. Orfanos, G.K. Steigleder, H. Pullmann, and P.H. Bloch Oral retinoid and UVB radiation: a new, alternative treatment for psoriasis on an outpatient basis Acta Derm Venereol 59 1979 241 244
5. J.V. Smit, E.M. De Jong, C.A. Van Hooijdonk, M.E. Otero, J.B. Boezeman, and P.C. Van De Kerkhof Systemic treatment of psoriatic patients with bexarotene decreases epidermal proliferation and parameters for inflammation, and improves differentiation in lesional skin J Am Acad Dermatol 51 2004 257 264
6. J.V. Smit, M.E. Franssen, E.M. De Jong, J. Lambert, D.I. Roseeuw, and J. De Weert A phase II multicenter clinical trial of systemic bexarotene in psoriasis J Am Acad Dermatol 51 2004 249 256
7. Moore AY. Oral bexarotene and narrowband UVB phototherapy in the treatment of moderate-to-severe plaque psoriasis. Poster 613 presented at: 61st Annual Meeting of the American Academy of Dermatology; March 21-26, 2003; San Francisco, CA.