Prothrombin overload causes thromboembolic complications in prothrombin complex concentrates: In vitro and in vivo evidence [1]

Thrombosis and Haemostasis

Volumn 94, Issue 6, 2005, Pages 1338-1339

  Grundmann, Claudia ^a   Plesker, Roland ^a   Kusch, Manuela ^a   Hanschmann, Kay Martin ^a   Eich, Stefanie ^a   Seitz, R Rainer ^a   König, Herbert ^a  

^a PAUL EHRLICH INSTITUT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 9A; PROTHROMBIN; PROTHROMBIN COMPLEX; THROMBIN;

BLOOD CLOTTING; DISEASE MODEL; FISHER EXACT TEST; HEMOPHILIA B; IN VITRO STUDY; IN VIVO STUDY; LETTER; NONHUMAN; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; THROMBOEMBOLISM; THROMBOGENICITY;

EID: 29244459681     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1615589     Document Type: Letter

References (20)

1. Brettler DB, Levine PH. Clinical manifestations and therapy of inherited coagulation factor deficiencies. In: Colman RW, Hirsh J, Marder VJ, Salzman EW (editors): Haemostasis and Thrombosis, 3rd edn. Philadelphia: J.B. Lippincott; 1994, 169-83.
2. Scharrer I. The need for highly purified products to treat haemophilia B. Acta Haematol 1995; 94 (suppl): 2-7.
3. Makris M, Greaves M, Phillips WS et al. Emergency oral anticoagulant reversal: the relative efficiency of infusions of fresh frozen plasma and clotting factor concentrate on correction of the coagulopathy. Thromb Haemost 1997; 77: 477-80.
4. Fredriksson K, Norrving B, Stromblad LG. Emergency reversal of anticoagulation after intracerebral hemorrhage. Stroke 1992; 23: 972-7.
5. Kasper CK. Clinical use of factor IX concentrates: report on thromboembolic complications. Thromb Diath Haemorrh 1975; 33: 642.
6. Ohga S, Saito M, Matsukazi A et al. Disseminated intravascular coagulation in a patient with haemophilia B during factor IX replacement therapy. Br J Haematol 1993; 84: 343-5.
7. Köhler M, Hellstern P, Lechler E et al. Thromboembolic complications associated with the use of prothrombin complex and factor IX concentrates. Thromb Haemost 1998; 80: 399-402.
8. Mannucci PM, Bauer KA, Gringeri A et al. No activation of the common pathway of the coagulation cascade after a highly purified factor IX concentrate. Br J Haematol 1991; 79: 606-11.
9. Philippou H, Adam A, Lane DA et al. High purity factor IX and prothrombin complex concentrate (PCC): pharmacokinetics and evidence that factor IXa is the thrombogenic trigger in PCC. Thromb Haemost 1996; 76: 23-8.
10. Gray E, Tubbs J, Oates TA et al. Measurement of activated factor IX in factor IX concentrates: correlation with in vivo thrombogenicity. Thromb Haemost 1995; 73: 675-9.
11. Lowe GDO. Factor IX and thrombosis. Br J Haematol 2001; 115: 507-13.
12. Kusch M, Seitz R, König H. High sensitivity detection of activated factor IX: application to the analysis of different therapeutical factor IX concentrates and prothrombin complexes. Thromb Haemost 1998; 79: 778-83.
13. Hanker-Dusel C, Grundmann C, Eich S et al. Identification of prothrombin as a major thrombogenic agent in prothrombin complex concentrates. Blood Coagul Fibrinolysis 2004; 15: 405-11.
14. Kingdon HS, Lundblad RL, Veltkamp JJ et al. Potentially thrombogenic materials in factor IX concentrates. Thromb Diath Haemorrh 1975; 33: 617-31.
15. Andrew M, Schmidt B, Mitchell L et al. Thrombin generation in newborn plasma is critically dependent on the concentration of prothrombin. Thromb Haemost 1990; 63: 27-30.
16. Wessler S, Reimer SM, Sheps MD. Biologic assay of a thrombosis- inducing activity in human serum. J Appl Physiol 1959; 14: 943-6.
17. Thomas DP. Venous thrombosis and the "Wessler test". Thromb Haemost 1996; 76: 1-4.
18. Lenting PJ, ter Maat H, Clijsters PPFM et al. Cleavage at arginine 145 in human blood coagulation factor IX converts the zymogen into a factor VIII binding enzyme. J Biol Chem 1995; 270: 14884-90.
19. Hemker HC, Beguin S. Thrombin generation in plasma: its assessment via the endogenous thrombin potential. Thromb Haemost 1995; 74: 134-8.
20. Butenas S, van't Veer C, Mann KG. Normal thrombin generation. Blood 1999; 94: 2169-78.