Uric acid - A uremic toxin?

Blood Purification

Volumn 24, Issue 1, 2006, Pages 67-70

  Nakagawa, Takahiko ^a   Mazzali, Marilda ^a   Kang, Duk Hee ^a   Sánchez Lozada, L Gabriela ^a   Herrera Acosta, Jaime ^a   Johnson, Richard J ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

Endothelial dysfunction; Glomerular hypertension; Uric acid; Vascular smooth muscle cell

Indexed keywords

CYCLOSPORIN; OXONIC ACID; UREMIC TOXIN; URIC ACID;

ARTERIOLOSCLEROSIS; CARDIOVASCULAR DISEASE; CELL INFILTRATION; CRYSTAL; DISEASE COURSE; GOUT; HYPERTENSION; HYPERURICEMIA; KIDNEY DISEASE; KIDNEY FAILURE; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALS; ARTERIOSCLEROSIS; BIOLOGICAL MARKERS; ENZYME INHIBITORS; HUMANS; HYPERTENSION; HYPERTROPHY; HYPERURICEMIA; KIDNEY; KIDNEY DISEASES; OXONIC ACID; RATS; URATE OXIDASE; URIC ACID;

EID: 29244457592     PISSN: 02535068     EISSN: None     Source Type: Journal    
DOI: 10.1159/000089440     Document Type: Review

References (23)

1. Johnson RJ, Feig DI, Herrera-Acosta J, Kang DH: Resurrection of uric acid as a causal risk factor in essential hypertension. Hypertension 2005;45:18-20.
2. Culleton BF, Larson MG, Kannel WB, Levy D: Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study. Ann Intern Med 1999;131:7-13.
3. Garrod PR, McSwiney RR, Bold AM: Investigation of renal excretion of phosphate and urate. Clin Sci 1966;31:9-17.
4. Messerli FH, Frohlich ED, Dreslinski GR, Suarez DH, Aristimuno GG: Serum uric acid in essential hypertension: an indicator of renal vascular involvement. Ann Intern Med 1980;93:817-821.
5. Sanchez-Lozada LG, Tapia E, Avila-Casado C, Soto V, Franco M, Santamaria J, Nakagawa T, Rodriguez-Iturbe B, Johnson RJ, Herrera-Acosta J: Mild hyperuricemia induces glomerular hypertension in normal rats. Am J Physiol Renal Physiol 2002;283:F1105-F1110.
6. Touitou Y, Touitou C, Bogdan A, Reinberg A, Motohashi Y, Auzeby A, Beck H: Circadian and seasonal variations of electrolytes in aging humans. Clin Chim Acta 1989;180:245-254.
7. Wu J, Chen X, Xie Y, Yamanaka N, Shi S, Wu D, Liu S, Cai G: Characteristics and risk factors of intrarenal arterial lesions in patients with IgA nephropathy. Nephrol Dial Transplant 2005;20:719-727.
8. Ohno I, Hosoya T, Gomi H, Ichida K, Okabe H, Hikita M: Serum uric acid and renal prognosis in patients with IgA nephropathy. Nephron 2001;87:333-339.
9. Myllymaki J, Honkanen T, Syrjanen J, Helin H, Rantala I, Pasternack A, Mustonen J: Uric acid correlates with the severity of histopathological parameters in IgA nephropathy. Nephrol Dial Transplant 2005;20:89-95.
10. Iseki K, Oshiro S, Tozawa M, Iseki C, Ikemiya Y, Takishita S: Significance of hyperuricemia on the early detection of renal failure in a cohort of screened subjects. Hypertens Res 2001;24:691-697.
11. Wu X, Wakamiya M, Vaishnav S, Geske R, Montgomery C Jr, Jones P, Bradley A, Caskey CT: Hyperuricemia and urate nephropathy in urate oxidase-deficient mice. Proc Natl Acad Sci USA 1994;91:742-746.
12. Mazzali M, Hughes J, Kim YG, Jefferson JA, Kang DH, Gordon KL, Lan HY, Kivlighn S, Johnson RJ: Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism. Hypertension 2001;38:1101-1106.
13. Kang DH, Nakagawa T, Feng L, Watanabe S, Han L, Mazzali M, Truong L, Harris R, Johnson RJ: A role for uric acid in the progression of renal disease. J Am Soc Nephrol 2002;13:2888-2897.
14. Mazzali M, Kim YG, Suga S, Gordon KL, Kang DH, Jefferson JA, Hughes J, Kivlighn SD, Lan HY, Johnson RJ: Hyperuricemia exacerbates chronic cyclosporine nephropathy. Transplantation 2001;71:900-905.
15. Nakagawa T, Mazzali M, Kang DH, Kanellis J, Watanabe S, Sanchez-Lozada LG, Rodriguez-Iturbe B, Herrera-Acosta J, Johnson RJ: Hyperuricemia causes glomerular hypertrophy in the rat. Am J Nephrol 2003;23:2-7.
16. Mazzali M, Kanellis J, Han L, Feng L, Xia YY, Chen Q, Kang DH, Gordon KL, Watanabe S, Nakagawa T, Lan HY, Johnson RJ: Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism. Am J Physiol Renal Physiol 2002;282:F991-F997.
17. Sanchez-Lozada LG, Tapia E, Santamaria J, Avila-Casado C, Soto V, Nepomuceno T, Rodriguez-Iturbe B, Johnson RJ, Herrera-Acosta J: Mild hyperuricemia induces vasoconstriction and maintains glomerular hypertension in normal and remnant kidney rats. Kidney Int 2005;67:237-247.
18. Kanellis J, Watanabe S, Li JH, Kang DH, Li P, Nakagawa T, Wamsley A, Sheikh-Hamad D, Lan HY, Feng L, Johnson RJ: Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2. Hypertension 2003;41:1287-1293.
19. Tomita M, Mizuno S, Yamanaka H, Hosoda Y, Sakuma K, Matuoka Y, Odaka M, Yamaguchi M, Yosida H, Morisawa H, Murayama T: Does hyperuricemia affect mortality? A prospective cohort study of Japanese male workers. J Epidemiol 2000;10:403-409.
20. Segura J, Campo C, Ruilope LM: How relevant and frequent is the presence of mild renal insufficiency in essential hypertension? J Clin Hypertens (Greenwich) 2002;4:332-336.
21. Tseng CH: Correlation of uric acid and urinary albumin excretion rate in patients with type 2 diabetes mellitus in Taiwan. Kidney Int 2005;68:796-801.
22. Shigematsu Y, Hamada M, Hiasa G, Sasaki O, Ohtsuka T, Hashida H, Ikeda S, Suzuki M, Hara Y, Hiwada K: Serum creatinine level underestimates hypertensive renal involvement in elderly patients with essential hypertension. Hypertens Res 1999;22:297-301.
23. Hunsicker LG, Adler S, Caggiula A, England BK, Greene T, Kusek JW, Rogers NL, Teschan PE: Predictors of the progression of renal disease in the Modification of Diet in Renal Disease Study. Kidney Int 1997;51:1908-1919.