Sodium channel dysfunction in intractable childhood epilepsy with generalized tonic-clonic seizures

Journal of Physiology

Volumn 569, Issue 2, 2005, Pages 433-445

  Rhodes, Thomas H ^a   Vanoye, Carlos G ^a   Ohmori, Iori ^a   Ogiwara, Ikuo ^b   Yamakawa, Kazuhiro ^b   George Jr , Alfred L ^a  

^a VANDERBILT UNIVERSITY   (United States)

^b RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

VOLTAGE GATED SODIUM CHANNEL; SODIUM CHANNEL NAV1.1;

ALLELE; ARTICLE; BENIGN CHILDHOOD EPILEPSY; CHANNEL GATING; CONTROLLED STUDY; DEPOLARIZATION; ELECTRIC POTENTIAL; GENE EXPRESSION; GENOTYPE PHENOTYPE CORRELATION; GRAND MAL SEIZURE; HUMAN; HUMAN CELL; HYPERPOLARIZATION; INTRACTABLE EPILEPSY; ION CONDUCTANCE; MAMMAL CELL; MISSENSE MUTATION; MUTANT; PATCH CLAMP; PHENOTYPE; PRIORITY JOURNAL; SODIUM CURRENT; STEADY STATE; TONIC CLONIC SEIZURE; WHOLE CELL; WILD TYPE; ACTION POTENTIAL AMPLITUDE; CHILD; ELECTRICAL CONDUCTIVITY PARAMETERS; GENETIC ASSOCIATION; INACTIVATION TIME CONSTANT; INTRACTABLE CHILDHOOD EPILEPSY WITH GENERALIZED TONIC CLONIC SEIZURE; MOLECULAR PATHOLOGY; SCN1A GENE; SLOW INACTIVATION; SODIUM CHANNELOPATHY; SODIUM CONDUCTANCE; WHOLE CELL PATCH CLAMP;

ALLELES; CHILD; EPILEPSIES, MYOCLONIC; EPILEPSY; GENOTYPE; HUMANS; ION CHANNEL GATING; MEMBRANE POTENTIALS; MUTATION; NERVE TISSUE PROTEINS; PATCH-CLAMP TECHNIQUES; PHENOTYPE; SEIZURES; SODIUM CHANNELS;

EID: 29244448307     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2005.094326     Document Type: Article

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