A nexus of progression of chronic kidney disease: Charcoal, tryptophan and profibrotic cytokines

Blood Purification

Volumn 24, Issue 1, 2006, Pages 143-148

  Schulman, Gerald ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AST 120; Indoxyl sulfate; Uremic toxins

Indexed keywords

AST 120; CHARCOAL; CREATININE; CYTOKINE; INDICAN; INDOLE; TRANSFORMING GROWTH FACTOR BETA; TRYPTOPHAN;

ADULT; AGED; ARTICLE; BACTERIAL MEMBRANE; BIFIDOBACTERIUM LONGUM; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE COURSE; DOSE RESPONSE; DRUG MECHANISM; FEMALE; HUMAN; KIDNEY DISEASE; KIDNEY FIBROSIS; LIVER METABOLISM; MALE; PRIORITY JOURNAL; URINE;

ADMINISTRATION, ORAL; ADULT; AGED; CARBON; CYTOKINES; ENDPOINT DETERMINATION; FEMALE; FIBROSIS; HUMANS; INDICAN; KIDNEY; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; OXIDES; TRYPTOPHAN;

EID: 29244436866     PISSN: 02535068     EISSN: None     Source Type: Journal    
DOI: 10.1159/000089451     Document Type: Article

References (15)

1. Lewis EJ, Hunsicker LG, Bain RP, Rohde RD: The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. N Engl J Med 1993;329:1456-1462.
2. Ruggenenti P, Perna A, Gherardi G, Garini G, Zoccali C, Salvadori M, Scolari F, Schena FP, Remuzzi G: Renoprotective properties of ACE inhibition in non-diabetic nephropathies with non-nephrotic proteinuria. Lancet 1999;354: 359-364.
3. Brenner BM, Cooper ME, de Zeeuw D, Keane WF, Mitch WE, Parving HH, Remuzzi G, Snapinn SM, Zhang Z, Shahinfar S, RENAAL Study Investigators: Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 2001;345:861-869.
4. Lewis EJ, Hunsicker LG, Clarke WR, Berl T, Pohl MA, Lewis JB, Ritz E, Atkins RC, Rohde R, Raz I, Collaborative Study Group: Reno-protective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. N Engl J Med 2001; 345:851-860.
5. Parving HH, Lehnert H, Brochner-Mortensen J, Gomis R, Andersen S, Arner P, Irbesartan in Patients with Type 2 Diabetes and Microalbuminuria Study Group: The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes. N Engl J Med 2001;345:870-878.
6. Vanholder R, De Smet R, Glorieux G, Argiles A, Baurmeister U, Brunet P, Clark W, Cohen G, De Deyn PP, Deppisch R, Descamps-Latscha B, Henle T, Jorres A, Lemke HD, Massy ZA, Passlick-Deetjen J, Rodriguez M, Stegmayr B, Stenvinkel P, Tetta C, Wanner C, Zidek W, European Uremic Toxin Work Group (EUTox): Review on uremic toxins: classification, concentration, and interindividual variability. Kidney Int 2003;63:1934-1943.
7. Niwa T, Ise M: Indoxyl sulfate, a circulating uremic toxin, stimulates the progression of glomerular sclerosis. J Lab Clin Med 1994;124: 96-104.
8. Miyazaki T, Ise M, Seo H, Niwa T: Indoxyl sulfate increases the gene expression of TGF-beta 1, TIMP-1 and pro-alpha 1(I) collagen in uremic rat kidneys. Kidney Int 1997;52:S15-S22.
9. Miyazaki T, Aoyama I, Ise M, Seo H, Niwa T: An oral sorbent reduces overload of indoxyl sulfate and gene expression of TGF-beta1 in uremic rat kidneys. Nephrol Dial Transplant 2000;15:1773-1781.
10. Motojima M, Hosokawa A, Yamato H, Muraki T, Yoshioka T: Uremic toxins of organic anions up-regulate PAI-1 expression by induction of NF-kappaB and free radical in proximal tubular cells. Kidney Int 2003;63:1671-1680.
11. Enomoto A, Takeda M, Tojo A, Sekine T, Cha SH, Khamdang S, Takayama F, Aoyama I, Nakamura S, Endou H, Niwa T: Role of organic anion transporters in the tubular transport of indoxyl sulfate and the induction of its nephrotoxicity. J Am Soc Nephrol 2002;13:1711-1720.
12. Niwa T, Yazawa T, Ise M, Sugano M, Kodama T, Uehara Y, Maeda K: Inhibitory effect of oral sorbent on accumulation of albumin-bound indoxyl sulfate in serum of experimental uremic rats. Nephron 1991;57:84-88.
13. Niwa T, Tsukushi S, Ise M, Miyazaki T, Tsubakihara Y, Owada A, Shiigai T: Indoxyl sulfate and progression of renal failure: effects of a low-protein diet and oral sorbent on indoxyl sulfate production in uremic rats and undialyzed uremic patients. Miner Electrolyte Metab 1997;23:179-184.
14. Owada A, Nakao M, Koike J, Ujiie K, Tomita K, Shiigai T: Effects of oral adsorbent AST-120 on the progression of chronic renal failure: a randomized controlled study. Kidney Int 1997; 52(suppl 63):S188-S190.
15. Ando Y, Miyata Y, Tanba K, Saito O, Muto S, Kurosu M, Homma S, Kasano E, Asano Y: Effect of oral intake of an enteric capsule preparation containg Bifidobacterium longum on the progression of chronic renal failure. Nippon Jinzo Gakkai Shi 2003;45:759-764.