Cryptic 6p21.3 duplications and triplication involving HMGA1 partially masked by add 6p in four cases of myelodysplasia

Cancer Genetics and Cytogenetics

Volumn 164, Issue 1, 2006, Pages 84-87

  Andrieux, Joris ^a,b   Geffroy, Sandrine ^a   Bilhou Nabera, Chrystèle ^c   Dupriez, Brigitte ^a   Demory, Jean Loup ^d   Bauters, Francis ^a   Laï, Jean Luc ^a,b   Dastugue, Nicole ^e  

^a LILLE UNIVERSITY HOSPITAL   (France)

^b Institut de Recherche sur le Cancer de Lille   (France)

^c HAUT LÉVÊQUE HOSPITAL   (France)

^d UNIVERSITÉ CATHOLIQUE DE LILLE   (France)

^e CHU PURPAN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; HIGH MOBILITY GROUP A PROTEIN; NUCLEAR PROTEIN;

ADULT; AGED; ARTICLE; CASE REPORT; CHROMOSOME 6; CYTOGENETICS; DNA BINDING; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE DUPLICATION; GENE OVEREXPRESSION; GENE REARRANGEMENT; GENE REPLICATION; HEMATOLOGY; HUMAN; LEUKEMIA; MALE; MYELODYSPLASIA; MYELOFIBROSIS; MYELOID METAPLASIA; PRIORITY JOURNAL; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

BACTERIA (MICROORGANISMS);

EID: 29244432826     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cancergencyto.2005.06.018     Document Type: Article

References (18)

1. J. Andrieux, J.L. Demory, B. Dupriez, S. Quief, I. Plantier, C. Roumier, F. Bauters, J.L. Lai, and J.P. Kerckaert Dysregulation and overexpression of HMGA2 in myelofibrosis with myeloid metaplasia Genes Chromosomes Cancer 39 2004 82 87
2. M.D. Odero, F.H. Grand, S. Iqbal, F. Ross, J.P. Roman, J.L. Vizmanos, J. Andrieux, J.L. Lai, M.J. Calasanz, and N.C. Cross Disruption and aberrant expression of HMGA2 as a consequence of diverse chromosomal translocations in myeloid malignancies Leukemia 19 2005 245 252
3. Z. Chen, B. Issa, L.J. Brothman, M. Hendricksen, D. Button, and A.R. Brothman Nonrandom rearrangements of 6p in malignant hematological disorders Cancer Genet Cytogenet 121 2000 22 25
4. Mitelman F, Johansson B, Mertens F, editors. Mitelman database of chromosome aberrations in cancer [Internet]. Updated November 2004. Accessed December 27, 2004. Available at: http://cgap.nci.nih.gov/Chromosomes/Mitelman.
5. ISCN 1995: an international system for human cytogenetic nomenclature (1995) F. Mitelman 1995 S. Karger Basel
6. F. Diana, R. Sgarra, G. Manfioletti, A. Rustighi, D. Poletto, M.T. Sciortino, A. Mastino, and V. Giancotti A link between apoptosis and degree of phosphorylation of high mobility group A1a protein in leukemic cells J Biol Chem 276 2001 11354 11361
7. M. Harrer, H. Luhrs, M. Bustin, U. Scheer, and R. Hock Dynamic interaction of HMGA1a proteins with chromatin J Cell Sci 117 2004 3459 3471
8. P. Dal Cin, S. Wanschura, M. Christiaens, I. Van den Berghe, P. Moerman, P. Polito, B. Kazmierczak, J. Bullerdiek, and H. Van den Berghe Hamartoma of the breast with involvement of 6p21 and rearrangement of HMGIY Genes Chromosomes Cancer 20 1997 90 92
9. J.L. Hess Chromosomal translocations in benign tumors: the HMGI proteins Am J Clin Pathol 1998 251 261
10. B. Kazmierczak, P. Dal Cin, S. Wanschura, L. Borrmann, A. Fusco, H. Van den Berghe, and J. Bullerdiek HMGIY is the target of 6p21.3 rearrangements in various benign mesenchymal tumors Genes Chromosomes Cancer 23 1998 279 285
11. K.S. Sornberger, S. Weremowicz, A.J. Williams, B.J. Quade, A.H. Ligon, F. Pedeutour, R. Vanni, and C.C. Morton Expression of HMGIY in three uterine leiomyomata with complex rearrangements of chromosome 6 Cancer Genet Cytogenet 114 1999 9 16
12. G.M. Pierantoni, V. Agosti, M. Fedele, H. Bond, I. Caliendo, G. Chiappetta, F. Lo Coco, F. Pane, M.C. Turco, G. Morrone, S. Venuta, and A. Fusco High-mobility group A1 proteins are overexpressed in human leukaemias Biochem J 372 2003 145 150
13. Y. Xu, T.F. Sumter, R. Bhattacharya, A. Tesfaye, E.J. Fuchs, L.J. Wood, D.L. Huso, and L.M. Resar The HMG-I oncogene causes highly penetrant, aggressive lymphoid malignancy in transgenic mice and is overexpressed in human leukemia Cancer Res 64 2004 3371 3375
14. C. Mecucci, J.L. Michaux, A. Louwagie, M. Boogaerts, and H. Van den Berghe The short arm of chromosome 6 is nonrandomly rearranged in secondary myelodysplastic syndromes Cancer Genet Cytogenet 31 1988 147 155
15. S. Giraudier, H. Chagraoui, E. Komura, S. Barnache, B. Blanchet, J.P. LeCouedic, D.F. Smith, F. Larbret, A.L. Taksin, F. Moreau-Gachelin, N. Casadevall, M. Tulliez, A. Hulin, N. Debili, and W. Vainchenker Overexpression of FKBP51 in idiopathic myelofibrosis regulates the growth factor independence of megakaryocyte progenitors Blood 100 2002 2932 2940
16. E. Komura, H. Chagraoui, V. Mansat de Mas, B. Blanchet, P. de Sepulveda, F. Larbret, J. Larghero, M. Tulliez, N. Debili, W. Vainchenker, and S. Giraudier Spontaneous STAT5 activation induces growth factor independence in idiopathic myelofibrosis: possible relationship with FKBP51 overexpression Exp Hematol 31 2003 622 630
17. O. Bock, M. Neusch, G. Busche, M. Mengel, and H. Kreipe Constitutive expression of the FK506 binding protein 51 (FKBP51) in bone marrow cells and megakaryocytes derived from idiopathic myelofibrosis and non-neoplastic haematopoiesis Eur J Haematol 72 2004 239 244
18. F.S. Harman, C.J. Nicol, H.E. Marin, J.M. Ward, F.J. Gonzalez, and J.M. Peters Peroxisome proliferator-activated receptor-delta attenuates colon carcinogenesis Nat Med 10 2004 481 483