Effect of charge and surface area on the cytotoxicity of cationic metallointercalation reagents

Canadian Journal of Chemistry

Volumn 83, Issue 6-7, 2005, Pages 969-979

  Edwards, Gavin L ^a   Black, David St C ^a   Deacon, Glen B ^b   Wakelin, Laurence P G ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

Anticancer; Cyclometallation; Cytotoxicity; Metallointercalator; Palladium; Platinum

Indexed keywords

COMPLEXATION; ENZYME INHIBITION; NITROGEN; PALLADIUM; PLATINUM; POSITIVE IONS; TOXICITY;

ANTICANCER; CYCLOMETALLATION; CYTOTOXICITY; METALLOINTERCALATOR;

INTERCALATION COMPOUNDS;

(1,2 ETHANEDIAMINE N,N')[1 (2' PYRIDYL)INDOL 2 YL N',C]PALLADIUM CHLORIDE; 1 (2' PYRIDYL)INDOLE; 1 PHENYLINDAZOLE; 1 PHENYLPYRAZOLE DERIVATIVE; 1,10 PHENANTHROLINE; 2 (1' PYRAZOLYL)PYRIDINE; 2 PHENYLINDAZOLE; 2 PHENYLPYRIDINE DERIVATIVE; 2,2' BIPYRIDINE; AROMATIC DIAMINE; BENZO[H]QUINOLINE; CARBON; CATION; CHELATING AGENT; CHLORINE DERIVATIVE; COORDINATION COMPOUND; DIAMINE; DICHLORO (1,2 ETHANEDIAMINE N,N')PALLADIUM; DIMER; ETHYLENEDIAMINE; FLUOROURACIL; INTERCALATING AGENT; LIGAND; METAL COMPLEX; NITROGEN; PALLADIUM COMPLEX; PLATINUM COMPLEX; REAGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; ATOM; CANCER INHIBITION; CHEMICAL REACTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYCLIZATION; DRUG CYTOTOXICITY; IN VITRO STUDY; IN VIVO STUDY; INTERCALATION COMPLEX; LEUKEMIA L 1210; LEUKEMIA P 388; METAL BINDING; METALLATION; MOUSE; NONHUMAN; SUBSTITUTION REACTION; SURFACE AREA; SURFACE CHARGE; SURFACE PROPERTY;

EID: 29244431936     PISSN: 00084042     EISSN: None     Source Type: Journal    
DOI: 10.1139/v05-110     Document Type: Article

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